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{
"metadata": {
"accession": "cd18094",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": "IPR016914",
"hierarchy": null,
"name": {
"name": "SAM-dependent tRNA methylase related to TrmL",
"short": "SpoU-like_TrmL"
},
"description": [
{
"text": "<p>tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot. [[cite:PUB00139656], [cite:PUB00060403], [cite:PUB00138600], [cite:PUB00044735], [cite:PUB00058164], [cite:PUB00138601]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00058164": {
"PMID": 11763972,
"ISBN": null,
"volume": "4",
"issue": "1",
"year": 2002,
"title": "SPOUT: a class of methyltransferases that includes spoU and trmD RNA methylase superfamilies, and novel superfamilies of predicted prokaryotic RNA methylases.",
"URL": null,
"raw_pages": "71-5",
"medline_journal": "J Mol Microbiol Biotechnol",
"ISO_journal": "J. Mol. Microbiol. Biotechnol.",
"authors": [
"Anantharaman V",
"Koonin EV",
"Aravind L."
],
"DOI_URL": null
},
"PUB00044735": {
"PMID": 17338813,
"ISBN": null,
"volume": "8",
"issue": null,
"year": 2007,
"title": "Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases.",
"URL": null,
"raw_pages": "73",
"medline_journal": "BMC Bioinformatics",
"ISO_journal": "BMC Bioinformatics",
"authors": [
"Tkaczuk KL",
"Dunin-Horkawicz S",
"Purta E",
"Bujnicki JM."
],
"DOI_URL": "http://dx.doi.org/10.1186/1471-2105-8-73"
},
"PUB00060403": {
"PMID": 20855540,
"ISBN": null,
"volume": "16",
"issue": "11",
"year": 2010,
"title": "YibK is the 2'-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNA(Leu) isoacceptors.",
"URL": null,
"raw_pages": "2131-43",
"medline_journal": "RNA",
"ISO_journal": "RNA",
"authors": [
"Benitez-Paez A",
"Villarroya M",
"Douthwaite S",
"Gabaldon T",
"Armengod ME."
],
"DOI_URL": "http://dx.doi.org/10.1261/rna.2245910"
},
"PUB00138601": {
"PMID": 28264529,
"ISBN": null,
"volume": "7",
"issue": "1",
"year": 2017,
"title": "Transfer RNA methyltransferases with a SpoU-TrmD (SPOUT) fold and their modified nucleosides in tRNA. ",
"URL": null,
"raw_pages": "E23",
"medline_journal": "Biomolecules",
"ISO_journal": "Biomolecules",
"authors": [
"Hori H."
],
"DOI_URL": null
},
"PUB00139656": {
"PMID": 23804755,
"ISBN": null,
"volume": "41",
"issue": "16",
"year": 2013,
"title": "The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL.",
"URL": null,
"raw_pages": "7828-42",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res",
"authors": [
"Liu RJ",
"Zhou M",
"Fang ZP",
"Wang M",
"Zhou XL",
"Wang ED."
],
"DOI_URL": null
},
"PUB00138600": {
"PMID": 18029778,
"ISBN": null,
"volume": null,
"issue": "51",
"year": 2007,
"title": "Differences in substrate selectivities of the SPOUT superfamily of methyltransferases.",
"URL": null,
"raw_pages": "445-6",
"medline_journal": "Nucleic Acids Symp Ser (Oxf)",
"ISO_journal": "Nucleic Acids Symp Ser (Oxf)",
"authors": [
"Toyooka T",
"Hori H."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl38912",
"name": "SPOUT_MTase"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 17725,
"pathways": 0,
"proteins": 17725,
"proteomes": 12048,
"sets": 1,
"structural_models": {
"alphafold": 13750,
"bfvd": 0
},
"structures": 21,
"taxa": 20528
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "3n4j",
"name": "Putative RNA methyltransferase from Yersinia pestis"
}
}
}
