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{
"metadata": {
"accession": "cd17665",
"entry_id": null,
"type": "domain",
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"source_database": "cdd",
"member_databases": null,
"integrated": null,
"hierarchy": null,
"name": {
"name": "dual-specificity phosphatase domain of dual specificity protein phosphatase 11 and similar proteins",
"short": "DSP_DUSP11"
},
"description": [
{
"text": "<p>dual specificity protein phosphatase 11 (DUSP11), also known as RNA/RNP complex-1-interacting phosphatase or phosphatase that interacts with RNA/RNP complex 1 (PIR1), has RNA 5'-triphosphatase and diphosphatase activity, but only poor protein-tyrosine phosphatase activity. It has activity for short RNAs but is less active toward mononucleotide triphosphates, suggesting that its primary function in vivo is to dephosphorylate RNA 5'-ends. It may play a role in nuclear mRNA metabolism. Also included in this subfamily is baculovirus RNA 5'-triphosphatase for Autographa californica nuclear polyhedrosis virus. [[cite:PUB00138705], [cite:PUB00038566], [cite:PUB00138706], [cite:PUB00138707], [cite:PUB00138870], [cite:PUB00138708], [cite:PUB00096302], [cite:PUB00056895], [cite:PUB00096300]]</p>",
"llm": false,
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}
],
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"literature": {
"PUB00138705": {
"PMID": 24447265,
"ISBN": null,
"volume": "53",
"issue": "5",
"year": 2014,
"title": "Structure of human PIR1, an atypical dual-specificity phosphatase.",
"URL": null,
"raw_pages": "862-71",
"medline_journal": "Biochemistry",
"ISO_journal": "Biochemistry",
"authors": [
"Sankhala RS",
"Lokareddy RK",
"Cingolani G."
],
"DOI_URL": null
},
"PUB00096302": {
"PMID": 27514797,
"ISBN": null,
"volume": "1447",
"issue": null,
"year": 2016,
"title": "The Extended Family of Protein Tyrosine Phosphatases.",
"URL": null,
"raw_pages": "1-23",
"medline_journal": "Methods Mol Biol",
"ISO_journal": "Methods Mol Biol",
"authors": [
"Alonso A",
"Nunes-Xavier CE",
"Bayon Y",
"Pulido R."
],
"DOI_URL": null
},
"PUB00138707": {
"PMID": 27798849,
"ISBN": null,
"volume": "30",
"issue": "18",
"year": 2016,
"title": "DUSP11 activity on triphosphorylated transcripts promotes Argonaute association with noncanonical viral microRNAs and regulates steady-state levels of cellular noncoding RNAs.",
"URL": null,
"raw_pages": "2076-2092",
"medline_journal": "Genes Dev",
"ISO_journal": "Genes Dev",
"authors": [
"Burke JM",
"Kincaid RP",
"Nottingham RM",
"Lambowitz AM",
"Sullivan CS."
],
"DOI_URL": null
},
"PUB00138708": {
"PMID": 15699333,
"ISBN": null,
"volume": "102",
"issue": "7",
"year": 2005,
"title": "A baculovirus-encoded protein tyrosine phosphatase gene induces enhanced locomotory activity in a lepidopteran host.",
"URL": null,
"raw_pages": "2584-9",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc Natl Acad Sci U S A",
"authors": [
"Kamita SG",
"Nagasaka K",
"Chua JW",
"Shimada T",
"Mita K",
"Kobayashi M",
"Maeda S",
"Hammock BD."
],
"DOI_URL": null
},
"PUB00096300": {
"PMID": 26573778,
"ISBN": null,
"volume": "283",
"issue": "8",
"year": 2016,
"title": "The extended human PTPome: a growing tyrosine phosphatase family.",
"URL": null,
"raw_pages": "1404-29",
"medline_journal": "FEBS J",
"ISO_journal": "FEBS J",
"authors": [
"Alonso A",
"Pulido R."
],
"DOI_URL": null
},
"PUB00038566": {
"PMID": 15713658,
"ISBN": null,
"volume": "280",
"issue": "18",
"year": 2005,
"title": "Crystal structure of baculovirus RNA triphosphatase complexed with phosphate.",
"URL": null,
"raw_pages": "17848-56",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Changela A",
"Martins A",
"Shuman S",
"Mondragon A."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M500885200"
},
"PUB00056895": {
"PMID": 17057753,
"ISBN": null,
"volume": "7",
"issue": "11",
"year": 2006,
"title": "Protein tyrosine phosphatases: from genes, to function, to disease.",
"URL": null,
"raw_pages": "833-46",
"medline_journal": "Nat Rev Mol Cell Biol",
"ISO_journal": "Nat. Rev. Mol. Cell Biol.",
"authors": [
"Tonks NK."
],
"DOI_URL": "http://dx.doi.org/10.1038/nrm2039"
},
"PUB00138870": {
"PMID": 19120688,
"ISBN": null,
"volume": "13",
"issue": "8B",
"year": 2009,
"title": "Isolation and characterization of DUSP11, a novel p53 target gene.",
"URL": null,
"raw_pages": "2158-2170",
"medline_journal": "J Cell Mol Med",
"ISO_journal": "J Cell Mol Med",
"authors": [
"Caprara G",
"Zamponi R",
"Melixetian M",
"Helin K."
],
"DOI_URL": null
},
"PUB00138706": {
"PMID": 28296624,
"ISBN": null,
"volume": "14",
"issue": "11",
"year": 2017,
"title": "DUSP11 - An RNA phosphatase that regulates host and viral non-coding RNAs in mammalian cells.",
"URL": null,
"raw_pages": "1457-1465",
"medline_journal": "RNA Biol",
"ISO_journal": "RNA Biol",
"authors": [
"Burke JM",
"Sullivan CS."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl28904",
"name": "PTP_DSP_cys"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 827,
"pathways": 0,
"proteins": 827,
"proteomes": 562,
"sets": 1,
"structural_models": {
"alphafold": 751,
"bfvd": 0
},
"structures": 5,
"taxa": 1879
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "1yn9",
"name": "Crystal structure of baculovirus RNA 5'-phosphatase complexed with phosphate"
}
}
}
