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{
"metadata": {
"accession": "cd17386",
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"type": "domain",
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"source_database": "cdd",
"member_databases": null,
"integrated": null,
"hierarchy": null,
"name": {
"name": "Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters",
"short": "MFS_SLC46"
},
"description": [
{
"text": "<p>The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. [[cite:PUB00140723], [cite:PUB00140724], [cite:PUB00140725], [cite:PUB00140726], [cite:PUB00140727], [cite:PUB00140728], [cite:PUB00140729], [cite:PUB00140730], [cite:PUB00140731], [cite:PUB00140732], [cite:PUB00140733], [cite:PUB00140734], [cite:PUB00140668], [cite:PUB00140669], [cite:PUB00140672], [cite:PUB00096970], [cite:PUB00102174], [cite:PUB00075603], [cite:PUB00094019], [cite:PUB00097058], [cite:PUB00102173]]</p>",
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"PUB00075603": {
"PMID": 26098515,
"ISBN": null,
"volume": "44",
"issue": null,
"year": 2015,
"title": "Structural Biology of the Major Facilitator Superfamily Transporters.",
"URL": null,
"raw_pages": "257-83",
"medline_journal": "Annu Rev Biophys",
"ISO_journal": "Annu Rev Biophys",
"authors": [
"Yan N."
],
"DOI_URL": "http://dx.doi.org/10.1146/annurev-biophys-060414-033901"
},
"PUB00094019": {
"PMID": 23530251,
"ISBN": null,
"volume": "110",
"issue": "15",
"year": 2013,
"title": "Evolutionary mix-and-match with MFS transporters.",
"URL": null,
"raw_pages": "5870-4",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Madej MG",
"Dang S",
"Yan N",
"Kaback HR."
],
"DOI_URL": null
},
"PUB00140724": {
"PMID": 24745983,
"ISBN": null,
"volume": "73",
"issue": null,
"year": 2014,
"title": "Biology of the major facilitative folate transporters SLC19A1 and SLC46A1.",
"URL": null,
"raw_pages": "175-204",
"medline_journal": "Curr Top Membr",
"ISO_journal": "Curr Top Membr",
"authors": [
"Hou Z",
"Matherly LH."
],
"DOI_URL": null
},
"PUB00140668": {
"PMID": 26013383,
"ISBN": null,
"volume": "38",
"issue": "6",
"year": 2015,
"title": "Expression Analyses Revealed Thymic Stromal Co-Transporter/Slc46A2 Is in Stem Cell Populations and Is a Putative Tumor Suppressor.",
"URL": null,
"raw_pages": "548-61",
"medline_journal": "Mol Cells",
"ISO_journal": "Mol Cells",
"authors": [
"Kim KY",
"Lee G",
"Yoon M",
"Cho EH",
"Park CS",
"Kim MG."
],
"DOI_URL": null
},
"PUB00140728": {
"PMID": 18823045,
"ISBN": null,
"volume": "98",
"issue": "5",
"year": 2009,
"title": "Molecular and functional characteristics of proton-coupled folate transporter.",
"URL": null,
"raw_pages": "1608-16",
"medline_journal": "J Pharm Sci",
"ISO_journal": "J Pharm Sci",
"authors": [
"Yuasa H",
"Inoue K",
"Hayashi Y."
],
"DOI_URL": null
},
"PUB00140734": {
"PMID": 27530302,
"ISBN": null,
"volume": "100",
"issue": "5",
"year": 2016,
"title": "Lysosomal solute carrier transporters gain momentum in research.",
"URL": null,
"raw_pages": "431-436",
"medline_journal": "Clin Pharmacol Ther",
"ISO_journal": "Clin Pharmacol Ther",
"authors": [
"Bissa B",
"Beedle AM",
"Govindarajan R."
],
"DOI_URL": null
},
"PUB00140732": {
"PMID": 20805364,
"ISBN": null,
"volume": "116",
"issue": "24",
"year": 2010,
"title": "Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.",
"URL": null,
"raw_pages": "5162-9",
"medline_journal": "Blood",
"ISO_journal": "Blood",
"authors": [
"Shin DS",
"Min SH",
"Russell L",
"Zhao R",
"Fiser A",
"Goldman ID."
],
"DOI_URL": null
},
"PUB00140669": {
"PMID": 23719032,
"ISBN": null,
"volume": "14",
"issue": "6",
"year": 2013,
"title": "Differential lineage specification of thymic epithelial cells from bipotent precursors revealed by TSCOT promoter activities.",
"URL": null,
"raw_pages": "401-6",
"medline_journal": "Genes Immun",
"ISO_journal": "Genes Immun",
"authors": [
"Park CS",
"Lee G",
"Yang SJ",
"Ahn S",
"Kim KY",
"Shin H",
"Kim MG."
],
"DOI_URL": null
},
"PUB00097058": {
"PMID": 23403214,
"ISBN": null,
"volume": "38",
"issue": "3",
"year": 2013,
"title": "Structural advances for the major facilitator superfamily (MFS) transporters.",
"URL": null,
"raw_pages": "151-9",
"medline_journal": "Trends Biochem Sci",
"ISO_journal": "Trends Biochem Sci",
"authors": [
"Yan N."
],
"DOI_URL": null
},
"PUB00140725": {
"PMID": 24396145,
"ISBN": null,
"volume": "42",
"issue": "4",
"year": 2014,
"title": "The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.",
"URL": null,
"raw_pages": "632-49",
"medline_journal": "Drug Metab Dispos",
"ISO_journal": "Drug Metab Dispos",
"authors": [
"Matherly LH",
"Wilson MR",
"Hou Z."
],
"DOI_URL": null
},
"PUB00140726": {
"PMID": 24383099,
"ISBN": null,
"volume": "13",
"issue": "6",
"year": 2013,
"title": "The proton-coupled folate transporter: physiological and pharmacological roles.",
"URL": null,
"raw_pages": "875-80",
"medline_journal": "Curr Opin Pharmacol",
"ISO_journal": "Curr Opin Pharmacol",
"authors": [
"Zhao R",
"Goldman ID."
],
"DOI_URL": null
},
"PUB00102173": {
"PMID": 18537473,
"ISBN": null,
"volume": "62",
"issue": null,
"year": 2008,
"title": "Ins and outs of major facilitator superfamily antiporters.",
"URL": null,
"raw_pages": "289-305",
"medline_journal": "Annu Rev Microbiol",
"ISO_journal": "Annu Rev Microbiol",
"authors": [
"Law CJ",
"Maloney PC",
"Wang DN."
],
"DOI_URL": null
},
"PUB00102174": {
"PMID": 26234418,
"ISBN": null,
"volume": "24",
"issue": "10",
"year": 2015,
"title": "Energy coupling mechanisms of MFS transporters.",
"URL": null,
"raw_pages": "1560-79",
"medline_journal": "Protein Sci",
"ISO_journal": "Protein Sci",
"authors": [
"Zhang XC",
"Zhao Y",
"Heng J",
"Jiang D."
],
"DOI_URL": null
},
"PUB00140672": {
"PMID": 18392855,
"ISBN": null,
"volume": "123",
"issue": "5",
"year": 2008,
"title": "Polymorphisms in 9q32 and TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis.",
"URL": null,
"raw_pages": "437-43",
"medline_journal": "Hum Genet",
"ISO_journal": "Hum Genet",
"authors": [
"Engelmark MT",
"Ivansson EL",
"Magnusson JJ",
"Gustavsson IM",
"Wyoni PI",
"Ingman M",
"Magnusson PK",
"Gyllensten UB."
],
"DOI_URL": null
},
"PUB00140723": {
"PMID": 27664775,
"ISBN": null,
"volume": "53",
"issue": null,
"year": 2017,
"title": "The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption.",
"URL": null,
"raw_pages": "57-72",
"medline_journal": "Mol Aspects Med",
"ISO_journal": "Mol Aspects Med",
"authors": [
"Zhao R",
"Aluri S",
"Goldman ID."
],
"DOI_URL": null
},
"PUB00140733": {
"PMID": 26631267,
"ISBN": null,
"volume": "75",
"issue": "24",
"year": 2015,
"title": "SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm.",
"URL": null,
"raw_pages": "5329-40",
"medline_journal": "Cancer Res",
"ISO_journal": "Cancer Res",
"authors": [
"Hamblett KJ",
"Jacob AP",
"Gurgel JL",
"Tometsko ME",
"Rock BM",
"Patel SK",
"Milburn RR",
"Siu S",
"Ragan SP",
"Rock DA",
"Borths CJ",
"O'Neill JW",
"Chang WS",
"Weidner MF",
"Bio MM",
"Quon KC",
"Fanslow WC."
],
"DOI_URL": null
},
"PUB00096970": {
"PMID": 26758938,
"ISBN": null,
"volume": "17",
"issue": "2",
"year": 2016,
"title": "Understanding transport by the major facilitator superfamily (MFS): structures pave the way.",
"URL": null,
"raw_pages": "123-32",
"medline_journal": "Nat Rev Mol Cell Biol",
"ISO_journal": "Nat Rev Mol Cell Biol",
"authors": [
"Quistgaard EM",
"Low C",
"Guettou F",
"Nordlund P."
],
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},
"PUB00140731": {
"PMID": 21333572,
"ISBN": null,
"volume": "103",
"issue": "1",
"year": 2011,
"title": "Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption.",
"URL": null,
"raw_pages": "33-7",
"medline_journal": "Mol Genet Metab",
"ISO_journal": "Mol Genet Metab",
"authors": [
"Shin DS",
"Mahadeo K",
"Min SH",
"Diop-Bove N",
"Clayton P",
"Zhao R",
"Goldman ID."
],
"DOI_URL": null
},
"PUB00140730": {
"PMID": 23601781,
"ISBN": null,
"volume": "280",
"issue": "12",
"year": 2013,
"title": "The monomeric state of the proton-coupled folate transporter represents the functional unit in the plasma membrane.",
"URL": null,
"raw_pages": "2900-15",
"medline_journal": "FEBS J",
"ISO_journal": "FEBS J",
"authors": [
"Duddempudi PK",
"Nakashe P",
"Blanton MP",
"Jansen M."
],
"DOI_URL": null
},
"PUB00140727": {
"PMID": 22954694,
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"volume": "13",
"issue": "14",
"year": 2012,
"title": "The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.",
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"raw_pages": "1355-73",
"medline_journal": "Cancer Biol Ther",
"ISO_journal": "Cancer Biol Ther",
"authors": [
"Desmoulin SK",
"Hou Z",
"Gangjee A",
"Matherly LH."
],
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},
"PUB00140729": {
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"volume": "289",
"issue": "36",
"year": 2014,
"title": "Substituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter.",
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"raw_pages": "25287-95",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Wilson MR",
"Hou Z",
"Matherly LH."
],
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}
},
"set_info": {
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"name": "MFS"
},
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}
}
