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{
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"name": {
"name": "FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in erythrocyte membrane protein band 4.1-like 5 (EPB41L5)",
"short": "FERM_F1_EPB41L5"
},
"description": [
{
"text": "<p>EPB41L5 is a mesenchymal-specific protein that is an integral component of the ARF6-based pathway. It is normally induced during epithelial-mesenchymal transition (EMT) by an EMT-related transcriptional factor, ZEB1, which drives ARF6-based invasion, metastasis and drug resistance. EPB41L5 also binds to paxillin to enhance integrin/paxillin association, and thus promotes focal adhesion dynamics. Moreover, EPB41L5 acts as a substrate for the E3 ubiquitin ligase Mind bomb 1 (Mib1), which is essential for activation of Notch signaling. EPB41L5 is a member of the band 4.1/Nbl4 (novel band 4.1-like protein 4) group of the FERM protein superfamily. It contains a FERM domain that is made up of three sub-domains, F1, F2, and F3. This family corresponds to the F1 sub-domain, which is also called the N-terminal ubiquitin-like structural domain of the FERM domain (FERM_N). [[cite:PUB00073790], [cite:PUB00138788], [cite:PUB00138789], [cite:PUB00138790], [cite:PUB00138791], [cite:PUB00138792]]</p>",
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"PUB00138792": {
"PMID": 18794329,
"ISBN": null,
"volume": "182",
"issue": "6",
"year": 2008,
"title": "EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition.",
"URL": null,
"raw_pages": "1217-30",
"medline_journal": "J Cell Biol",
"ISO_journal": "J Cell Biol",
"authors": [
"Hirano M",
"Hashimoto S",
"Yonemura S",
"Sabe H",
"Aizawa S."
],
"DOI_URL": null
},
"PUB00138788": {
"PMID": 28536193,
"ISBN": null,
"volume": "114",
"issue": "23",
"year": 2017,
"title": "The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier.",
"URL": null,
"raw_pages": "E4621-E4630",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc Natl Acad Sci U S A",
"authors": [
"Schell C",
"Rogg M",
"Suhm M",
"Helmstadter M",
"Sellung D",
"Yasuda-Yamahara M",
"Kretz O",
"Kuttner V",
"Suleiman H",
"Kollipara L",
"Zahedi RP",
"Sickmann A",
"Eimer S",
"Shaw AS",
"Kramer-Zucker A",
"Hirano-Kobayashi M",
"Abe T",
"Aizawa S",
"Grahammer F",
"Hartleben B",
"Dengjel J",
"Huber TB."
],
"DOI_URL": null
},
"PUB00138790": {
"PMID": 27617643,
"ISBN": null,
"volume": "5",
"issue": "9",
"year": 2016,
"title": "ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance.",
"URL": null,
"raw_pages": "e259",
"medline_journal": "Oncogenesis",
"ISO_journal": "Oncogenesis",
"authors": [
"Hashimoto A",
"Hashimoto S",
"Sugino H",
"Yoshikawa A",
"Onodera Y",
"Handa H",
"Oikawa T",
"Sabe H."
],
"DOI_URL": null
},
"PUB00138791": {
"PMID": 27510968,
"ISBN": null,
"volume": "143",
"issue": "17",
"year": 2016,
"title": "Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons.",
"URL": null,
"raw_pages": "3085-96",
"medline_journal": "Development",
"ISO_journal": "Development",
"authors": [
"Matsuda M",
"Rand K",
"Palardy G",
"Shimizu N",
"Ikeda H",
"Dalle Nogare D",
"Itoh M",
"Chitnis AB."
],
"DOI_URL": null
},
"PUB00138789": {
"PMID": 27754741,
"ISBN": null,
"volume": "9",
"issue": "5",
"year": 2018,
"title": "Arf6 and its ZEB1-EPB41L5 mesenchymal axis are required for both mesenchymal- and amoeboid-type invasion of cancer cells.",
"URL": null,
"raw_pages": "420-426",
"medline_journal": "Small GTPases",
"ISO_journal": "Small GTPases",
"authors": [
"Handa H",
"Hashimoto A",
"Hashimoto S",
"Sabe H."
],
"DOI_URL": null
},
"PUB00073790": {
"PMID": 17920587,
"ISBN": null,
"volume": "313",
"issue": "19",
"year": 2007,
"title": "FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5 polarity complex.",
"URL": null,
"raw_pages": "3959-70",
"medline_journal": "Exp Cell Res",
"ISO_journal": "Exp. Cell Res.",
"authors": [
"Gosens I",
"Sessa A",
"den Hollander AI",
"Letteboer SJ",
"Belloni V",
"Arends ML",
"Le Bivic A",
"Cremers FP",
"Broccoli V",
"Roepman R."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.yexcr.2007.08.025"
}
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}
}
