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"name": "FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in kindlin-2 (KIND2)",
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},
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{
"text": "<p>KIND2, also termed fermitin family homolog 2 (FERMT2), or mitogen-inducible gene 2 protein (MIG-2), or Pleckstrin homology (PH) domain-containing family C member 1, is an adaptor protein that is widely distributed and is particularly abundant in adherent cells. It binds to the integrin beta cytoplasmic tail to promote integrin activation. It promotes carcinogenesis through regulation of cell-cell and cell-extracellular matrix adhesion. KIND2 also plays an important role in cardiac development. KIND2 consists of an atypical FERM domain that is made up of F1, F2 and F3 domains, as well as an N-terminal region, which precedes the FERM domain and has been referred to as the F0 domain. This family corresponds to the F1 domain. [[cite:PUB00138951], [cite:PUB00138952], [cite:PUB00138953], [cite:PUB00087692], [cite:PUB00138954], [cite:PUB00138955], [cite:PUB00138956], [cite:PUB00138957], [cite:PUB00087693], [cite:PUB00066081], [cite:PUB00138958], [cite:PUB00138959], [cite:PUB00138960], [cite:PUB00138961], [cite:PUB00138962], [cite:PUB00138963], [cite:PUB00138964], [cite:PUB00138965]]</p>",
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"volume": "9",
"issue": "8",
"year": 2016,
"title": "Postnatal Loss of Kindlin-2 Leads to Progressive Heart Failure. ",
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"raw_pages": "e003129",
"medline_journal": "Circ Heart Fail",
"ISO_journal": "Circ Heart Fail",
"authors": [
"Zhang Z",
"Mu Y",
"Veevers J",
"Peter AK",
"Manso AM",
"Bradford WH",
"Dalton ND",
"Peterson KL",
"Knowlton KU",
"Ross RS",
"Zhou X",
"Chen J."
],
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},
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"volume": "5",
"issue": null,
"year": 2016,
"title": "Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin.",
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"raw_pages": "e10130",
"medline_journal": "Elife",
"ISO_journal": "Elife",
"authors": [
"Theodosiou M",
"Widmaier M",
"Bottcher RT",
"Rognoni E",
"Veelders M",
"Bharadwaj M",
"Lambacher A",
"Austen K",
"Muller DJ",
"Zent R",
"Fassler R."
],
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},
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"issue": "3",
"year": 2008,
"title": "Kindlin-2 (Mig-2): a co-activator of beta3 integrins.",
"URL": null,
"raw_pages": "439-46",
"medline_journal": "J Cell Biol",
"ISO_journal": "J Cell Biol",
"authors": [
"Ma YQ",
"Qin J",
"Wu C",
"Plow EF."
],
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},
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"title": "Tracing the evolution of FERM domain of Kindlins.",
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"raw_pages": "193-204",
"medline_journal": "Mol Phylogenet Evol",
"ISO_journal": "Mol Phylogenet Evol",
"authors": [
"Ali RH",
"Khan AA."
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"medline_journal": "Structure",
"ISO_journal": "Structure",
"authors": [
"Perera HD",
"Ma YQ",
"Yang J",
"Hirbawi J",
"Plow EF",
"Qin J."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.str.2011.08.012"
},
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"volume": "59",
"issue": "11",
"year": 2016,
"title": "Depletion of Kindlin-2 induces cardiac dysfunction in mice.",
"URL": null,
"raw_pages": "1123-1130",
"medline_journal": "Sci China Life Sci",
"ISO_journal": "Sci China Life Sci",
"authors": [
"Qi L",
"Yu Y",
"Chi X",
"Lu D",
"Song Y",
"Zhang Y",
"Zhang H."
],
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},
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"issue": "1",
"year": 2016,
"title": "The kindlin family: functions, signaling properties and implications for human disease.",
"URL": null,
"raw_pages": "17-27",
"medline_journal": "J Cell Sci",
"ISO_journal": "J Cell Sci",
"authors": [
"Rognoni E",
"Ruppert R",
"Fassler R."
],
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},
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"issue": "1",
"year": 2016,
"title": "Kindlin-2 directly binds actin and regulates integrin outside-in signaling.",
"URL": null,
"raw_pages": "97-108",
"medline_journal": "J Cell Biol",
"ISO_journal": "J Cell Biol",
"authors": [
"Bledzka K",
"Bialkowska K",
"Sossey-Alaoui K",
"Vaynberg J",
"Pluskota E",
"Qin J",
"Plow EF."
],
"DOI_URL": null
},
"PUB00087692": {
"PMID": 12697302,
"ISBN": null,
"volume": "1637",
"issue": "3",
"year": 2003,
"title": "URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas.",
"URL": null,
"raw_pages": "207-16",
"medline_journal": "Biochim Biophys Acta",
"ISO_journal": "Biochim. Biophys. Acta",
"authors": [
"Weinstein EJ",
"Bourner M",
"Head R",
"Zakeri H",
"Bauer C",
"Mazzarella R."
],
"DOI_URL": "https://doi.org/10.1016/S0925-4439(03)00035-8"
},
"PUB00138965": {
"PMID": 26551397,
"ISBN": null,
"volume": "576",
"issue": "1 Pt 3",
"year": 2016,
"title": "Kindlin-2 promotes invasiveness of prostate cancer cells via NF-κB-dependent upregulation of matrix metalloproteinases.",
"URL": null,
"raw_pages": "571-6",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Yang JR",
"Pan TJ",
"Yang H",
"Wang T",
"Liu W",
"Liu B",
"Qian WH."
],
"DOI_URL": null
},
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"PMID": 22699938,
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"volume": "13",
"issue": "8",
"year": 2012,
"title": "Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling.",
"URL": null,
"raw_pages": "750-8",
"medline_journal": "EMBO Rep",
"ISO_journal": "EMBO Rep",
"authors": [
"Yu Y",
"Wu J",
"Wang Y",
"Zhao T",
"Ma B",
"Liu Y",
"Fang W",
"Zhu WG",
"Zhang H."
],
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},
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"PMID": 27713156,
"ISBN": null,
"volume": "7",
"issue": "46",
"year": 2016,
"title": "Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression.",
"URL": null,
"raw_pages": "74872-74885",
"medline_journal": "Oncotarget",
"ISO_journal": "Oncotarget",
"authors": [
"Ou Y",
"Zhao Z",
"Zhang W",
"Wu Q",
"Wu C",
"Liu X",
"Fu M",
"Ji N",
"Wang D",
"Qiu J",
"Zhang L",
"Yu C",
"Song Y",
"Zhan Q."
],
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},
"PUB00138954": {
"PMID": 12679033,
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"volume": "113",
"issue": "1",
"year": 2003,
"title": "Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation.",
"URL": null,
"raw_pages": "37-47",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Tu Y",
"Wu S",
"Shi X",
"Chen K",
"Wu C."
],
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"PUB00087693": {
"PMID": 22030399,
"ISBN": null,
"volume": "286",
"issue": "50",
"year": 2011,
"title": "Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation.",
"URL": null,
"raw_pages": "43334-42",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Liu J",
"Fukuda K",
"Xu Z",
"Ma YQ",
"Hirbawi J",
"Mao X",
"Wu C",
"Plow EF",
"Qin J."
],
"DOI_URL": "https://doi.org/10.1074/jbc.M111.295352"
},
"PUB00138958": {
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"volume": "3",
"issue": "6",
"year": 2012,
"title": "Crystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activation.",
"URL": null,
"raw_pages": "434-40",
"medline_journal": "Protein Cell",
"ISO_journal": "Protein Cell",
"authors": [
"Liu Y",
"Zhu Y",
"Ye S",
"Zhang R."
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"volume": "4",
"issue": "2",
"year": 2016,
"title": "Of Kindlins and Cancer. ",
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"medline_journal": "Discoveries (Craiova)",
"ISO_journal": "Discoveries (Craiova)",
"authors": [
"Plow EF",
"Das M",
"Bialkowska K",
"Sossey-Alaoui K."
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"volume": "6",
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"year": 2016,
"title": "Increased expression of kindlin-2 is correlated with hematogenous metastasis and poor prognosis in patients with clear cell renal cell carcinoma.",
"URL": null,
"raw_pages": "660-5",
"medline_journal": "FEBS Open Bio",
"ISO_journal": "FEBS Open Bio",
"authors": [
"Yan M",
"Zhang L",
"Wu Y",
"Gao L",
"Yang W",
"Li J",
"Chen Y",
"Jin X."
],
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},
"PUB00138956": {
"PMID": 21325030,
"ISBN": null,
"volume": "124",
"issue": "Pt 6",
"year": 2011,
"title": "Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins.",
"URL": null,
"raw_pages": "879-91",
"medline_journal": "J Cell Sci",
"ISO_journal": "J Cell Sci",
"authors": [
"Qu H",
"Tu Y",
"Shi X",
"Larjava H",
"Saleem MA",
"Shattil SJ",
"Fukuda K",
"Qin J",
"Kretzler M",
"Wu C."
],
"DOI_URL": null
}
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}
