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{
"metadata": {
"accession": "cd17175",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": null,
"hierarchy": null,
"name": {
"name": "FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)",
"short": "FERM_F0_SHANK1"
},
"description": [
{
"text": "<p>SHANK1, also termed somatostatin receptor-interacting protein, or SSTR-interacting protein (SSTRIP), is a postsynaptic density (PSD)-associated scaffolding proteins at the excitatory synapse that interconnects neurotransmitter receptors and cell adhesion molecules by direct and indirect interactions with numerous other PSD-associated proteins. Mutations in the SHANK1 synaptic scaffolding gene may lead to autism spectrum disorder and mental retardation. SHANK1 contains an N-terminal F0 domain of FERM (Band 4.1, ezrin, radixin, moesin), six ankyrin (ANK) repeats, one SH3 (Src homology 3) domain, one PDZ (PSD-95, Dlg, and ZO-1/2, also termed DHR or GLGF) domain, and a C-terminal SAM (sterile alpha motif) domain. This family corresponds to the F0 domain that adopts a ubiquitin-like fold. [[cite:PUB00130042], [cite:PUB00086096], [cite:PUB00139043], [cite:PUB00139015], [cite:PUB00139044], [cite:PUB00139045], [cite:PUB00139046], [cite:PUB00057073], [cite:PUB00139047]]</p>",
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"literature": {
"PUB00139043": {
"PMID": 10551867,
"ISBN": null,
"volume": "274",
"issue": "46",
"year": 1999,
"title": "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain.",
"URL": null,
"raw_pages": "32997-3001",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Zitzer H",
"Honck HH",
"Bachner D",
"Richter D",
"Kreienkamp HJ."
],
"DOI_URL": null
},
"PUB00139044": {
"PMID": 26335738,
"ISBN": null,
"volume": "58",
"issue": "10",
"year": 2015,
"title": "SHANK1 and autism spectrum disorders.",
"URL": null,
"raw_pages": "985-90",
"medline_journal": "Sci China Life Sci",
"ISO_journal": "Sci China Life Sci",
"authors": [
"Gong X",
"Wang H."
],
"DOI_URL": null
},
"PUB00139046": {
"PMID": 22503632,
"ISBN": null,
"volume": "90",
"issue": "5",
"year": 2012,
"title": "SHANK1 Deletions in Males with Autism Spectrum Disorder.",
"URL": null,
"raw_pages": "879-87",
"medline_journal": "Am J Hum Genet",
"ISO_journal": "Am J Hum Genet",
"authors": [
"Sato D",
"Lionel AC",
"Leblond CS",
"Prasad A",
"Pinto D",
"Walker S",
"O'Connor I",
"Russell C",
"Drmic IE",
"Hamdan FF",
"Michaud JL",
"Endris V",
"Roeth R",
"Delorme R",
"Huguet G",
"Leboyer M",
"Rastam M",
"Gillberg C",
"Lathrop M",
"Stavropoulos DJ",
"Anagnostou E",
"Weksberg R",
"Fombonne E",
"Zwaigenbaum L",
"Fernandez BA",
"Roberts W",
"Rappold GA",
"Marshall CR",
"Bourgeron T",
"Szatmari P",
"Scherer SW."
],
"DOI_URL": null
},
"PUB00139015": {
"PMID": 27795858,
"ISBN": null,
"volume": "2016",
"issue": null,
"year": 2016,
"title": "Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies.",
"URL": null,
"raw_pages": "8051861",
"medline_journal": "Neural Plast",
"ISO_journal": "Neural Plast",
"authors": [
"Sarowar T",
"Grabrucker AM."
],
"DOI_URL": null
},
"PUB00139047": {
"PMID": 12136153,
"ISBN": null,
"volume": "58",
"issue": "Pt 8",
"year": 2002,
"title": "Crystallization and preliminary X-ray crystallographic studies of the PDZ domain of Shank1 from Rattus norvegicus.",
"URL": null,
"raw_pages": "1353-5",
"medline_journal": "Acta Crystallogr D Biol Crystallogr",
"ISO_journal": "Acta Crystallogr D Biol Crystallogr",
"authors": [
"Park SH",
"Im YJ",
"Rho SH",
"Lee JH",
"Yang S",
"Kim E",
"Eom SH."
],
"DOI_URL": null
},
"PUB00086096": {
"PMID": 10806096,
"ISBN": null,
"volume": "113 ( Pt 11)",
"issue": null,
"year": 2000,
"title": "The Shank family of scaffold proteins.",
"URL": null,
"raw_pages": "1851-6",
"medline_journal": "J Cell Sci",
"ISO_journal": "J. Cell. Sci.",
"authors": [
"Sheng M",
"Kim E."
],
"DOI_URL": null
},
"PUB00057073": {
"PMID": 21376703,
"ISBN": null,
"volume": "407",
"issue": "1",
"year": 2011,
"title": "The structural flexibility of the shank1 PDZ domain is important for its binding to different ligands.",
"URL": null,
"raw_pages": "207-12",
"medline_journal": "Biochem Biophys Res Commun",
"ISO_journal": "Biochem. Biophys. Res. Commun.",
"authors": [
"Lee JH",
"Park H",
"Park SJ",
"Kim HJ",
"Eom SH."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.bbrc.2011.02.141"
},
"PUB00139045": {
"PMID": 25816842,
"ISBN": null,
"volume": "41",
"issue": "8",
"year": 2015,
"title": "Shank1 regulates excitatory synaptic transmission in mouse hippocampal parvalbumin-expressing inhibitory interneurons.",
"URL": null,
"raw_pages": "1025-35",
"medline_journal": "Eur J Neurosci",
"ISO_journal": "Eur J Neurosci",
"authors": [
"Mao W",
"Watanabe T",
"Cho S",
"Frost JL",
"Truong T",
"Zhao X",
"Futai K."
],
"DOI_URL": null
},
"PUB00130042": {
"PMID": 12504591,
"ISBN": null,
"volume": "21",
"issue": "4",
"year": 2002,
"title": "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42.",
"URL": null,
"raw_pages": "575-83",
"medline_journal": "Mol Cell Neurosci",
"ISO_journal": "Mol Cell Neurosci",
"authors": [
"Soltau M",
"Richter D",
"Kreienkamp HJ."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl28922",
"name": "Ubl1_cv_Nsp3_N-like"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 368,
"pathways": 0,
"proteins": 368,
"proteomes": 133,
"sets": 1,
"structural_models": {
"alphafold": 28,
"bfvd": 0
},
"structures": 0,
"taxa": 466
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
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"representative_structure": null
}
}
