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{
"metadata": {
"accession": "cd16817",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": null,
"hierarchy": null,
"name": {
"name": "Modified RING finger, HC subclass (C3HC5-type), found in RING finger protein 157 (RNF157) and similar proteins",
"short": "mRING-HC-C3HC5_RNF157"
},
"description": [
{
"text": "<p>RNF157 is a cytoplasmic E3 ubiquitin ligase predominantly expressed in brain. It is a homolog of the E3 ligase mahogunin ring finger-1 (MGRN1). In cultured neurons, it promotes neuronal survival in an E3 ligase-dependent manner. In contrast, it supports growth and maintenance of dendrites independent of its E3 ligase activity. RNF157 interacts with and ubiquitinates the adaptor protein APBB1 (amyloid beta precursor protein-binding, family B, member 1 or Fe65), which regulates neuronal survival, but not dendritic growth downstream of RNF157. The nuclear localization of APBB1 together with its interaction partner RNA-binding protein SART3 (squamous cell carcinoma antigen recognized by T cells 3 or Tip110) is crucial to trigger apoptosis. RNF157 contains a modified C3HC5-type RING-HC finger, and a functionally uncharacterized region, known as domain associated with RING2 (DAR2), N-terminal to the RING finger. The C3HC5-type RING-HC finger is distinguished from typical C3HC4 RING-HC finger due to the existence of the additional cysteine residue in the middle portion of the RING finger domain. [[cite:PUB00098244]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00098244": {
"PMID": 25342469,
"ISBN": null,
"volume": "22",
"issue": "4",
"year": 2015,
"title": "Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157.",
"URL": null,
"raw_pages": "626-42",
"medline_journal": "Cell Death Differ",
"ISO_journal": "Cell Death Differ",
"authors": [
"Matz A",
"Lee SJ",
"Schwedhelm-Domeyer N",
"Zanini D",
"Holubowska A",
"Kannan M",
"Farnworth M",
"Jahn O",
"Gopfert MC",
"Stegmuller J."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl17238",
"name": "RING_Ubox"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 1293,
"pathways": 0,
"proteins": 1293,
"proteomes": 553,
"sets": 1,
"structural_models": {
"alphafold": 1175,
"bfvd": 0
},
"structures": 0,
"taxa": 1819
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
