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{
"metadata": {
"accession": "cd16297",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": null,
"hierarchy": null,
"name": {
"name": "artemis-SNM1C and related proteins; MBL-fold metallo-hydrolase domain",
"short": "artemis-SNM1C-like_MBL-fold"
},
"description": [
{
"text": "<p>Includes the nuclease artemis (also known as SNM1C, SNM1 homolog C, SNM1-like protein and DNA cross-link repair 1C protein) which plays a role in V(D)J recombination/DNA repair. Purified artemis protein possesses single-strand-specific 5' to 3' exonuclease activity. Upon complex formation with, and phosphorylation by, DNA-dependent protein kinase, artemis gains endonucleolytic activity on hairpins and 5' and 3' overhangs. Inactivation of Artemis causes severe combined immunodeficiency (SCID). Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. [[cite:PUB00137625], [cite:PUB00136090], [cite:PUB00137626], [cite:PUB00137627], [cite:PUB00137628], [cite:PUB00137629], [cite:PUB00137630], [cite:PUB00004473], [cite:PUB00087023], [cite:PUB00085867], [cite:PUB00087024], [cite:PUB00001273]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00137627": {
"PMID": 14744996,
"ISBN": null,
"volume": "199",
"issue": "3",
"year": 2004,
"title": "The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination.",
"URL": null,
"raw_pages": "315-21",
"medline_journal": "J Exp Med",
"ISO_journal": "J Exp Med",
"authors": [
"Poinsignon C",
"Moshous D",
"Callebaut I",
"de Chasseval R",
"Villey I",
"de Villartay JP."
],
"DOI_URL": null
},
"PUB00137629": {
"PMID": 16914548,
"ISBN": null,
"volume": "281",
"issue": "45",
"year": 2006,
"title": "DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs.",
"URL": null,
"raw_pages": "33900-9",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Niewolik D",
"Pannicke U",
"Lu H",
"Ma Y",
"Wang LC",
"Kulesza P",
"Zandi E",
"Lieber MR",
"Schwarz K."
],
"DOI_URL": null
},
"PUB00087023": {
"PMID": 11471246,
"ISBN": null,
"volume": "1",
"issue": "2",
"year": 1999,
"title": "An evolutionary classification of the metallo-beta-lactamase fold proteins.",
"URL": null,
"raw_pages": "69-91",
"medline_journal": "In Silico Biol",
"ISO_journal": "In Silico Biol. (Gedrukt)",
"authors": [
"Aravind L."
],
"DOI_URL": null
},
"PUB00004473": {
"PMID": 9108146,
"ISBN": null,
"volume": "25",
"issue": "9",
"year": 1997,
"title": "Extracting protein alignment models from the sequence database.",
"URL": null,
"raw_pages": "1665-77",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res.",
"authors": [
"Neuwald AF",
"Liu JS",
"Lipman DJ",
"Lawrence CE."
],
"DOI_URL": "http://dx.doi.org/10.1093/nar/25.9.1665"
},
"PUB00137630": {
"PMID": 17453916,
"ISBN": null,
"volume": "42",
"issue": "2",
"year": 2007,
"title": "Nucleases of the metallo-beta-lactamase family and their role in DNA and RNA metabolism.",
"URL": null,
"raw_pages": "67-93",
"medline_journal": "Crit Rev Biochem Mol Biol",
"ISO_journal": "Crit Rev Biochem Mol Biol",
"authors": [
"Dominski Z."
],
"DOI_URL": null
},
"PUB00137628": {
"PMID": 11955432,
"ISBN": null,
"volume": "108",
"issue": "6",
"year": 2002,
"title": "Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination.",
"URL": null,
"raw_pages": "781-94",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Ma Y",
"Pannicke U",
"Schwarz K",
"Lieber MR."
],
"DOI_URL": null
},
"PUB00085867": {
"PMID": 11513844,
"ISBN": null,
"volume": "503",
"issue": "1",
"year": 2001,
"title": "Expansion of the zinc metallo-hydrolase family of the beta-lactamase fold.",
"URL": null,
"raw_pages": "1-6",
"medline_journal": "FEBS Lett",
"ISO_journal": "FEBS Lett.",
"authors": [
"Daiyasu H",
"Osaka K",
"Ishino Y",
"Toh H."
],
"DOI_URL": "https://doi.org/10.1016/S0014-5793(01)02686-2"
},
"PUB00001273": {
"PMID": 7588620,
"ISBN": null,
"volume": "14",
"issue": "20",
"year": 1995,
"title": "The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold.",
"URL": null,
"raw_pages": "4914-21",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Carfi A",
"Pares S",
"Duee E",
"Galleni M",
"Duez C",
"Frere JM",
"Dideberg O."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=7588620"
},
"PUB00137626": {
"PMID": 12727634,
"ISBN": null,
"volume": "987",
"issue": null,
"year": 2003,
"title": "The V(D)J recombination/DNA repair factor artemis belongs to the metallo-beta-lactamase family and constitutes a critical developmental checkpoint of the lymphoid system.",
"URL": null,
"raw_pages": "150-7",
"medline_journal": "Ann N Y Acad Sci",
"ISO_journal": "Ann N Y Acad Sci",
"authors": [
"Moshous D",
"Callebaut I",
"de Chasseval R",
"Poinsignon C",
"Villey I",
"Fischer A",
"de Villartay JP."
],
"DOI_URL": null
},
"PUB00137625": {
"PMID": 11336668,
"ISBN": null,
"volume": "105",
"issue": "2",
"year": 2001,
"title": "Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.",
"URL": null,
"raw_pages": "177-86",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Moshous D",
"Callebaut I",
"de Chasseval R",
"Corneo B",
"Cavazzana-Calvo M",
"Le Deist F",
"Tezcan I",
"Sanal O",
"Bertrand Y",
"Philippe N",
"Fischer A",
"de Villartay JP."
],
"DOI_URL": null
},
"PUB00087024": {
"PMID": 17597585,
"ISBN": null,
"volume": "74",
"issue": "12",
"year": 2007,
"title": "Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily.",
"URL": null,
"raw_pages": "1686-701",
"medline_journal": "Biochem Pharmacol",
"ISO_journal": "Biochem. Pharmacol.",
"authors": [
"Bebrone C."
],
"DOI_URL": "https://doi.org/10.1016/j.bcp.2007.05.021"
},
"PUB00136090": {
"PMID": 15572677,
"ISBN": null,
"volume": "24",
"issue": "24",
"year": 2004,
"title": "DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation.",
"URL": null,
"raw_pages": "10733-41",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol Cell Biol",
"authors": [
"Ishiai M",
"Kimura M",
"Namikoshi K",
"Yamazoe M",
"Yamamoto K",
"Arakawa H",
"Agematsu K",
"Matsushita N",
"Takeda S",
"Buerstedde JM",
"Takata M."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl23716",
"name": "metallo-hydrolase-like_MBL-fold"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 528,
"pathways": 0,
"proteins": 528,
"proteomes": 287,
"sets": 1,
"structural_models": {
"alphafold": 464,
"bfvd": 0
},
"structures": 11,
"taxa": 1104
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
