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{
"metadata": {
"accession": "cd16270",
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"name": {
"name": "N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)",
"short": "Apc5_N"
},
"description": [
{
"text": "<p>The N-terminal domain of Apc5 interacts with subunits Apc4, Apc15, and CDC23. Apc5 is a subunit of the eukaryotic anaphase-promoting complex/cyclosome (APC/C) which is a multi-subunit ubiquitin ligase that mediates the proteolysis of cell cycle proteins in mitosis and G1. Although Apc5 does not contain a classical RNA binding domain, it binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) of growth factor 2 mRNA. PABP was found to enhance IRES-mediated translation, whereas Apc5 over-expression counteracted this effect. In addition to its association with the APC/C complex, Apc5 binds much heavier complexes and co-sediments with the ribosomal fraction. The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC. [[cite:PUB00059189], [cite:PUB00055977], [cite:PUB00137946], [cite:PUB00137947], [cite:PUB00137948]]</p>",
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"PUB00055977": {
"PMID": 16896351,
"ISBN": null,
"volume": "7",
"issue": "9",
"year": 2006,
"title": "The anaphase promoting complex/cyclosome: a machine designed to destroy.",
"URL": null,
"raw_pages": "644-56",
"medline_journal": "Nat Rev Mol Cell Biol",
"ISO_journal": "Nat. Rev. Mol. Cell Biol.",
"authors": [
"Peters JM."
],
"DOI_URL": "http://dx.doi.org/10.1038/nrm1988"
},
"PUB00137947": {
"PMID": 18082611,
"ISBN": null,
"volume": "28",
"issue": "5",
"year": 2007,
"title": "Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1.",
"URL": null,
"raw_pages": "871-85",
"medline_journal": "Mol Cell",
"ISO_journal": "Mol Cell",
"authors": [
"Ohi MD",
"Feoktistova A",
"Ren L",
"Yip C",
"Cheng Y",
"Chen JS",
"Yoon HJ",
"Wall JS",
"Huang Z",
"Penczek PA",
"Gould KL",
"Walz T."
],
"DOI_URL": null
},
"PUB00059189": {
"PMID": 15082755,
"ISBN": null,
"volume": "24",
"issue": "9",
"year": 2004,
"title": "The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation.",
"URL": null,
"raw_pages": "3577-87",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Koloteva-Levine N",
"Pinchasi D",
"Pereman I",
"Zur A",
"Brandeis M",
"Elroy-Stein O."
],
"DOI_URL": "http://dx.doi.org/10.1128/MCB.24.9.3577-3587.2004"
},
"PUB00137946": {
"PMID": 26343760,
"ISBN": null,
"volume": "427",
"issue": "20",
"year": 2015,
"title": "Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.",
"URL": null,
"raw_pages": "3300-3315",
"medline_journal": "J Mol Biol",
"ISO_journal": "J Mol Biol",
"authors": [
"Cronin NB",
"Yang J",
"Zhang Z",
"Kulkarni K",
"Chang L",
"Yamano H",
"Barford D."
],
"DOI_URL": null
},
"PUB00137948": {
"PMID": 23922952,
"ISBN": null,
"volume": "8",
"issue": "7",
"year": 2013,
"title": "The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction.",
"URL": null,
"raw_pages": "e70168",
"medline_journal": "PLoS One",
"ISO_journal": "PLoS One",
"authors": [
"Ho AW",
"Garg AV",
"Monin L",
"Simpson-Abelson MR",
"Kinner L",
"Gaffen SL."
],
"DOI_URL": null
}
},
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"structural_models": {
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},
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"taxa": 4078
},
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"is_llm": false,
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}
}
