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{
"metadata": {
"accession": "cd15723",
"entry_id": null,
"type": "domain",
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"source_database": "cdd",
"member_databases": null,
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"name": {
"name": "FYVE-related domain found in protrudin and similar proteins",
"short": "FYVE_protrudin"
},
"description": [
{
"text": "<p>Protrudin, also termed zinc finger FYVE domain-containing protein 27 (ZFY27 or ZFYVE27), is a FYVE domain-containing protein involved in transport of neuronal cargoes and implicated in the onset of hereditary spastic paraplegia (HSP). It is involved in neurite outgrowth through binding to spastin. Moreover, it functions as a key regulator of the Rab11-dependent membrane trafficking during neurite extension. It serves as an adaptor molecule that links its associated proteins, such as Rab11-GDP, VAP-A and -B, Surf4, and RTN3, to KIF5, a motor protein that mediates anterograde vesicular transport in neurons, and thus plays a key role in the maintenance of neuronal function. The FYVE domain of protrudin resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. In addition, unlike canonical FYVE domains that is located to early endosomes and specifically binds to phosphatidylinositol 3-phosphate (PtdIns3P or PI3P), the FYVE domain of protrudin is located to plasma membrane and preferentially binds phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2), and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). In addition to FYVE-related domain, protrudin also contains a Rab11-binding domain (RBD11), two hydrophobic domains, HP-1 and HP-2, an FFAT motif, and a coiled-coil domain. [[cite:PUB00133504], [cite:PUB00092941], [cite:PUB00133505], [cite:PUB00133506], [cite:PUB00133507], [cite:PUB00133508], [cite:PUB00133509], [cite:PUB00133510], [cite:PUB00133511]]</p>",
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"literature": {
"PUB00133507": {
"PMID": 23043110,
"ISBN": null,
"volume": "287",
"issue": "49",
"year": 2012,
"title": "Phosphoinositides differentially regulate protrudin localization through the FYVE domain.",
"URL": null,
"raw_pages": "41268-76",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Gil JE",
"Kim E",
"Kim IS",
"Ku B",
"Park WS",
"Oh BH",
"Ryu SH",
"Cho W",
"Heo WD."
],
"DOI_URL": null
},
"PUB00092941": {
"PMID": 19289470,
"ISBN": null,
"volume": "284",
"issue": "20",
"year": 2009,
"title": "Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein.",
"URL": null,
"raw_pages": "13766-77",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Saita S",
"Shirane M",
"Natume T",
"Iemura S",
"Nakayama KI."
],
"DOI_URL": null
},
"PUB00133509": {
"PMID": 22216323,
"ISBN": null,
"volume": "6",
"issue": "12",
"year": 2011,
"title": "Oligomerization of ZFYVE27 (Protrudin) is necessary to promote neurite extension.",
"URL": null,
"raw_pages": "e29584",
"medline_journal": "PLoS One",
"ISO_journal": "PLoS One",
"authors": [
"Pantakani DV",
"Czyzewska MM",
"Sikorska A",
"Bodda C",
"Mannan AU."
],
"DOI_URL": null
},
"PUB00133511": {
"PMID": 17082457,
"ISBN": null,
"volume": "314",
"issue": "5800",
"year": 2006,
"title": "Protrudin induces neurite formation by directional membrane trafficking.",
"URL": null,
"raw_pages": "818-21",
"medline_journal": "Science",
"ISO_journal": "Science",
"authors": [
"Shirane M",
"Nakayama KI."
],
"DOI_URL": null
},
"PUB00133505": {
"PMID": 16826525,
"ISBN": null,
"volume": "79",
"issue": "2",
"year": 2006,
"title": "ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia.",
"URL": null,
"raw_pages": "351-7",
"medline_journal": "Am J Hum Genet",
"ISO_journal": "Am J Hum Genet",
"authors": [
"Mannan AU",
"Krawen P",
"Sauter SM",
"Boehm J",
"Chronowska A",
"Paulus W",
"Neesen J",
"Engel W."
],
"DOI_URL": null
},
"PUB00133508": {
"PMID": 22573551,
"ISBN": null,
"volume": "113",
"issue": "7",
"year": 2012,
"title": "Role of spastin and protrudin in neurite outgrowth.",
"URL": null,
"raw_pages": "2296-307",
"medline_journal": "J Cell Biochem",
"ISO_journal": "J Cell Biochem",
"authors": [
"Zhang C",
"Li D",
"Ma Y",
"Yan J",
"Yang B",
"Li P",
"Yu A",
"Lu C",
"Ma X."
],
"DOI_URL": null
},
"PUB00133506": {
"PMID": 18606302,
"ISBN": null,
"volume": "83",
"issue": "1",
"year": 2008,
"title": "The role of ZFYVE27/protrudin in hereditary spastic paraplegia.",
"URL": null,
"raw_pages": "127-8; author reply 128-30",
"medline_journal": "Am J Hum Genet",
"ISO_journal": "Am J Hum Genet",
"authors": [
"Martignoni M",
"Riano E",
"Rugarli EI."
],
"DOI_URL": null
},
"PUB00133504": {
"PMID": 18459960,
"ISBN": null,
"volume": "13",
"issue": "6",
"year": 2008,
"title": "Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse.",
"URL": null,
"raw_pages": "635-51",
"medline_journal": "Genes Cells",
"ISO_journal": "Genes Cells",
"authors": [
"Shirane M",
"Ogawa M",
"Motoyama J",
"Nakayama KI."
],
"DOI_URL": null
},
"PUB00133510": {
"PMID": 21976701,
"ISBN": null,
"volume": "22",
"issue": "23",
"year": 2011,
"title": "Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation.",
"URL": null,
"raw_pages": "4602-20",
"medline_journal": "Mol Biol Cell",
"ISO_journal": "Mol Biol Cell",
"authors": [
"Matsuzaki F",
"Shirane M",
"Matsumoto M",
"Nakayama KI."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl28890",
"name": "FYVE_like_SF"
},
"overlaps_with": null,
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"matches": 1565,
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"sets": 1,
"structural_models": {
"alphafold": 1440,
"bfvd": 0
},
"structures": 1,
"taxa": 2249
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
