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"name": "primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors",
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{
"text": "<p>The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. [[cite:PUB00060243], [cite:PUB00135639], [cite:PUB00135640], [cite:PUB00087043], [cite:PUB00092608], [cite:PUB00087044], [cite:PUB00092609], [cite:PUB00092610], [cite:PUB00092621], [cite:PUB00092622], [cite:PUB00092623], [cite:PUB00092624], [cite:PUB00092625], [cite:PUB00134938], [cite:PUB00000131], [cite:PUB00063816], [cite:PUB00092620], [cite:PUB00092616], [cite:PUB00092612], [cite:PUB00092619]]</p>",
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"authors": [
"Katritch V",
"Cherezov V",
"Stevens RC."
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"title": "The GPCR Network: a large-scale collaboration to determine human GPCR structure and function.",
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"medline_journal": "Nat Rev Drug Discov",
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"Stevens RC",
"Cherezov V",
"Katritch V",
"Abagyan R",
"Kuhn P",
"Rosen H",
"Wuthrich K."
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"title": "Emerging opportunities for allosteric modulation of G-protein coupled receptors.",
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"medline_journal": "Biochem Pharmacol",
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"Wang CI",
"Lewis RJ."
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"authors": [
"Schoneberg T",
"Hofreiter M",
"Schulz A",
"Rompler H."
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"Kobilka BK."
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"title": "G-protein-coupled receptor structure, ligand binding and activation as studied by solid-state NMR spectroscopy.",
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"authors": [
"Ding X",
"Zhao X",
"Watts A."
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"Kobilka BK."
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"Latek D",
"Modzelewska A",
"Trzaskowski B",
"Palczewski K",
"Filipek S."
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"year": 2014,
"title": "Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes.",
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"Premzl M."
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"title": "Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.",
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"authors": [
"Liu Q",
"Tang Z",
"Surdenikova L",
"Kim S",
"Patel KN",
"Kim A",
"Ru F",
"Guan Y",
"Weng HJ",
"Geng Y",
"Undem BJ",
"Kollarik M",
"Chen ZF",
"Anderson DJ",
"Dong X."
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"Rosenbaum DM",
"Rasmussen SG",
"Kobilka BK."
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"Weis WI",
"Kobilka BK."
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"title": "Diversity and modularity of G protein-coupled receptor structures.",
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"medline_journal": "Trends Pharmacol Sci",
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"authors": [
"Katritch V",
"Cherezov V",
"Stevens RC."
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"title": "Structure-based drug screening for G-protein-coupled receptors.",
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"medline_journal": "Trends Pharmacol Sci",
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"authors": [
"Shoichet BK",
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"medline_journal": "Plant Signal Behav",
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"Tuteja N."
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"title": "G protein-coupled receptor deorphanizations.",
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"authors": [
"Civelli O",
"Reinscheid RK",
"Zhang Y",
"Wang Z",
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"Venkatakrishnan AJ",
"Deupi X",
"Lebon G",
"Tate CG",
"Schertler GF",
"Babu MM."
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"Birnbaumer L."
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"title": "Activation of Mas oncogene-related gene (Mrg) C receptors enhances morphine-induced analgesia through modulation of coupling of μ-opioid receptor to Gi-protein in rat spinal dorsal horn.",
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"Wang D",
"Chen T",
"Zhou X",
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"Hong Y."
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"Topiol S",
"Sabio M."
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