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{
"metadata": {
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"name": {
"name": "Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain",
"short": "bZIP_CREBL2"
},
"description": [
{
"text": "<p>CREBL2 is a bZIP transcription factor that interacts with CREB and plays a critical role in adipogenesis and lipogenesis. Its overexpression upregulates the expression of PPARgamma and CEBPalpha to promote adipogenesis as well as accelerate lipogenesis by increasing GLUT1 and GLUT4. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription. [[cite:PUB00134126], [cite:PUB00134127], [cite:PUB00134128], [cite:PUB00089362], [cite:PUB00128138], [cite:PUB00128139], [cite:PUB00128137], [cite:PUB00004967]]</p>",
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"PUB00089362": {
"PMID": 9693048,
"ISBN": null,
"volume": "51",
"issue": "1",
"year": 1998,
"title": "CREBL2, a novel transcript from the chromosome 12 region flanked by ETV6 and CDKN1B.",
"URL": null,
"raw_pages": "154-7",
"medline_journal": "Genomics",
"ISO_journal": "Genomics",
"authors": [
"Hoornaert I",
"Marynen P",
"Baens M."
],
"DOI_URL": "https://doi.org/10.1006/geno.1998.5366"
},
"PUB00128139": {
"PMID": 16580748,
"ISBN": null,
"volume": "1759",
"issue": "1-2",
"year": 2006,
"title": "Deciphering B-ZIP transcription factor interactions in vitro and in vivo.",
"URL": null,
"raw_pages": "4-12",
"medline_journal": "Biochim Biophys Acta",
"ISO_journal": "Biochim Biophys Acta",
"authors": [
"Vinson C",
"Acharya A",
"Taparowsky EJ."
],
"DOI_URL": null
},
"PUB00128138": {
"PMID": 16731568,
"ISBN": null,
"volume": "23",
"issue": "8",
"year": 2006,
"title": "Cross-species annotation of basic leucine zipper factor interactions: Insight into the evolution of closed interaction networks.",
"URL": null,
"raw_pages": "1480-92",
"medline_journal": "Mol Biol Evol",
"ISO_journal": "Mol Biol Evol",
"authors": [
"Deppmann CD",
"Alvania RS",
"Taparowsky EJ."
],
"DOI_URL": null
},
"PUB00128137": {
"PMID": 8504253,
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"volume": "3",
"issue": "2",
"year": 1993,
"title": "Interactions of coiled coils in transcription factors: where is the specificity?",
"URL": null,
"raw_pages": "278-85",
"medline_journal": "Curr Opin Genet Dev",
"ISO_journal": "Curr Opin Genet Dev",
"authors": [
"Baxevanis AD",
"Vinson CR."
],
"DOI_URL": null
},
"PUB00134126": {
"PMID": 21728997,
"ISBN": null,
"volume": "439",
"issue": "1",
"year": 2011,
"title": "CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes.",
"URL": null,
"raw_pages": "27-38",
"medline_journal": "Biochem J",
"ISO_journal": "Biochem J",
"authors": [
"Ma X",
"Zhang H",
"Yuan L",
"Jing H",
"Thacker P",
"Li D."
],
"DOI_URL": null
},
"PUB00134127": {
"PMID": 18063805,
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"volume": "104",
"issue": "2",
"year": 2008,
"title": "AMP-activated protein kinase phosphorylates transcription factors of the CREB family.",
"URL": null,
"raw_pages": "429-38",
"medline_journal": "J Appl Physiol (1985)",
"ISO_journal": "J Appl Physiol (1985)",
"authors": [
"Thomson DM",
"Herway ST",
"Fillmore N",
"Kim H",
"Brown JD",
"Barrow JR",
"Winder WW."
],
"DOI_URL": null
},
"PUB00134128": {
"PMID": 23077088,
"ISBN": null,
"volume": "52",
"issue": "2",
"year": 2013,
"title": "Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia.",
"URL": null,
"raw_pages": "202-13",
"medline_journal": "Genes Chromosomes Cancer",
"ISO_journal": "Genes Chromosomes Cancer",
"authors": [
"Al-Shehhi H",
"Konn ZJ",
"Schwab CJ",
"Erhorn A",
"Barber KE",
"Wright SL",
"Gabriel AS",
"Harrison CJ",
"Moorman AV."
],
"DOI_URL": null
},
"PUB00004967": {
"PMID": 7780801,
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"volume": "2",
"issue": "2",
"year": 1995,
"title": "Transcription factors 1: bZIP proteins.",
"URL": null,
"raw_pages": "101-68",
"medline_journal": "Protein Profile",
"ISO_journal": null,
"authors": [
"Hurst HC."
],
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}
},
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"name": "bZIP"
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"alphafold": 1261,
"bfvd": 0
},
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"is_llm": false,
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}
}
