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"name": "Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV",
"short": "STKc_CaMKIV"
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{
"text": "<p>STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKIV is found predominantly in neurons and immune cells. It is activated by the binding of calcium/CaM and phosphorylation by CaMKK (alpha or beta). The CaMKK-CaMKIV cascade participates in regulating several transcription factors like CREB, MEF2, and retinoid orphan receptors. It also is implicated in T-cell development and signaling, cytokine secretion, and signaling through Toll-like receptors, and is thus, pivotal in immune response and inflammation. The CaMKIV subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. [[cite:PUB00093160], [cite:PUB00118259], [cite:PUB00093162], [cite:PUB00118257], [cite:PUB00118261], [cite:PUB00118260], [cite:PUB00118263], [cite:PUB00118262], [cite:PUB00118264], [cite:PUB00131456], [cite:PUB00131457], [cite:PUB00131458], [cite:PUB00131459], [cite:PUB00131460], [cite:PUB00131461], [cite:PUB00131462], [cite:PUB00131463], [cite:PUB00131464], [cite:PUB00131465], [cite:PUB00131466], [cite:PUB00131467], [cite:PUB00034837], [cite:PUB00131468]]</p>",
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"authors": [
"Santulli G",
"Cipolletta E",
"Sorriento D",
"Del Giudice C",
"Anastasio A",
"Monaco S",
"Maione AS",
"Condorelli G",
"Puca A",
"Trimarco B",
"Illario M",
"Iaccarino G."
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"Anderson KA",
"Noeldner PK",
"Reece K",
"Wadzinski BE",
"Means AR."
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"title": "Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells.",
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"Illario M",
"Giardino-Torchia ML",
"Sankar U",
"Ribar TJ",
"Galgani M",
"Vitiello L",
"Masci AM",
"Bertani FR",
"Ciaglia E",
"Astone D",
"Maulucci G",
"Cavallo A",
"Vitale M",
"Cimini V",
"Pastore L",
"Means AR",
"Rossi G",
"Racioppi L."
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"medline_journal": "Trends Immunol",
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"Racioppi L",
"Means AR."
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"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Dias WB",
"Cheung WD",
"Wang Z",
"Hart GW."
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"medline_journal": "Biochim Biophys Acta",
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"authors": [
"Krebs J."
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"title": "Calcium/calmodulin-dependent protein kinase IV (CaMKIV) enhances osteoclast differentiation via the up-regulation of Notch1 protein stability.",
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"medline_journal": "Biochim Biophys Acta",
"ISO_journal": "Biochim Biophys Acta",
"authors": [
"Choi YH",
"Ann EJ",
"Yoon JH",
"Mo JS",
"Kim MY",
"Park HS."
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"authors": [
"Wayman GA",
"Lee YS",
"Tokumitsu H",
"Silva AJ",
"Silva A",
"Soderling TR."
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"title": "Decreased levels of Ca²⁺-calmodulin-dependent protein kinase IV in the testis as a contributing factor to reduced fertility in male Crybb2⁻/⁻ mice.",
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"medline_journal": "Int J Mol Med",
"ISO_journal": "Int J Mol Med",
"authors": [
"Xiang F",
"Cui B",
"Gao Q",
"Zhang J",
"Zhang J",
"Li W."
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"Chin ER."
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"medline_journal": "Neuroscience",
"ISO_journal": "Neuroscience",
"authors": [
"Nagendran T",
"Hardy LR."
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"authors": [
"Malovini A",
"Illario M",
"Iaccarino G",
"Villa F",
"Ferrario A",
"Roncarati R",
"Anselmi CV",
"Novelli V",
"Cipolletta E",
"Leggiero E",
"Orro A",
"Rusciano MR",
"Milanesi L",
"Maione AS",
"Condorelli G",
"Bellazzi R",
"Puca AA."
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"medline_journal": "Trends Biochem Sci",
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"Soderling TR."
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"title": "Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease.",
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"medline_journal": "Subcell Biochem",
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"Colomer J",
"Means AR."
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"title": "Ca2+/calmodulin-dependent protein kinase IV and calcium signaling.",
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"medline_journal": "Biometals",
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"authors": [
"Anderson KA",
"Kane CD."
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"title": "The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription.",
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"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
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"Chow FA",
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"Noeldner PK",
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"title": "Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.",
"URL": null,
"raw_pages": "185-93",
"medline_journal": "Cancer Lett",
"ISO_journal": "Cancer Lett",
"authors": [
"Takai N",
"Miyazaki T",
"Nishida M",
"Nasu K",
"Miyakawa I."
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"title": "NR2B-containing NMDA receptors promote neural progenitor cell proliferation through CaMKIV/CREB pathway.",
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"medline_journal": "Biochem Biophys Res Commun",
"ISO_journal": "Biochem Biophys Res Commun",
"authors": [
"Li M",
"Zhang DQ",
"Wang XZ",
"Xu TJ."
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"medline_journal": "Cell Calcium",
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"Wayman GA",
"Tokumitsu H",
"Davare MA",
"Soderling TR."
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"medline_journal": "Proc Nutr Soc",
"ISO_journal": "Proc Nutr Soc",
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"Chin ER."
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"title": "Involvement of CaMKIV in neurogenic effect with chronic fluoxetine treatment.",
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"medline_journal": "Int J Neuropsychopharmacol",
"ISO_journal": "Int J Neuropsychopharmacol",
"authors": [
"Song N",
"Nakagawa S",
"Izumi T",
"Toda H",
"Kato A",
"Boku S",
"Inoue T",
"Sakagami H",
"Li X",
"Koyama T."
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"title": "Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IV.",
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"authors": [
"Guan Y",
"Chen Q",
"Yang X",
"Haines P",
"Pei M",
"Terek R",
"Wei X",
"Zhao T",
"Wei L."
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"Suzuki A",
"Nomoto M",
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"Wu LJ",
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"Zhao MG",
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"Mamiya N",
"Yoshida T",
"Homma S",
"Masushige S",
"Zhuo M",
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