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"name": "Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137",
"short": "TNFRSF9"
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{
"text": "<p>TNFRSF9 (also known as CD137, ILA, 4-1BB) plays a role in the immunobiology of human cancer where it is preferentially expressed on tumor-reactive subset of tumor-infiltrating lymphocytes. It can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. It transduces signals that lead to the activation of NF-kappaB, mediated by the TRAF adaptor proteins. CD137 contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. CD137 is modulated by SAHA treatment in breast cancer cells, suggesting that the combination of SAHA with this receptor could be a new therapeutic approach for the treatment of tumors. [[cite:PUB00082225], [cite:PUB00082226], [cite:PUB00082227], [cite:PUB00082228], [cite:PUB00082229], [cite:PUB00082230], [cite:PUB00082231], [cite:PUB00082232], [cite:PUB00082233], [cite:PUB00082234], [cite:PUB00046030], [cite:PUB00082235], [cite:PUB00000892], [cite:PUB00082045], [cite:PUB00082046], [cite:PUB00005358], [cite:PUB00046032], [cite:PUB00082047], [cite:PUB00082048], [cite:PUB00082068], [cite:PUB00082069]]</p>",
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"Cheng K",
"Wong SC",
"Linn YC",
"Ho LP",
"Chng WJ",
"Schwarz H."
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"Schall TJ",
"Lewis M",
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"Lee A",
"Rice GC",
"Wong GH",
"Gatanaga T",
"Granger GA",
"Lentz R",
"Raab H."
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"Chacon JA",
"Wu RC",
"Sukhumalchandra P",
"Molldrem JJ",
"Sarnaik A",
"Pilon-Thomas S",
"Weber J",
"Hwu P",
"Radvanyi L."
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"Duong CP",
"Chesi M",
"Bergsagel PL",
"Sharp LL",
"Huhn RD",
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"Johnstone RW",
"Kershaw MH."
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"Banner DW",
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"Janes W",
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"Schoenfeld HJ",
"Broger C",
"Loetscher H",
"Lesslauer W."
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"Litjens NH",
"de Wit EA",
"Baan CC",
"Betjes MG."
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"Zhao S",
"Xing Y",
"Natkunam Y."
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"Bodmer JL",
"Schneider P",
"Tschopp J."
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"Moran AE",
"Kovacsovics-Bankowski M",
"Weinberg AD."
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"Sprang SR."
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"medline_journal": "J Immunotoxicol",
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"Simeone E",
"Ascierto PA."
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"Locksley RM",
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"medline_journal": "Int J Oncol",
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"Bellarosa D",
"Bressan A",
"Bigioni M",
"Parlani M",
"Maggi CA",
"Binaschi M."
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"Chan FK."
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"Netsawang J",
"Panaampon J",
"Khunchai S",
"Kooptiwut S",
"Nagila A",
"Puttikhunt C",
"Yenchitsomanus PT",
"Limjindaporn T."
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"Best A",
"Li C",
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"Powell DJ Jr."
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