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{
"metadata": {
"accession": "cd12619",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": null,
"hierarchy": null,
"name": {
"name": "RNA recognition motif 2 (RRM2) found in yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1 and similar proteins",
"short": "RRM2_PUB1"
},
"description": [
{
"text": "<p>This subgroup corresponds to the RRM2 of yeast protein PUB1, also termed ARS consensus-binding protein ACBP-60, or poly uridylate-binding protein, or poly(U)-binding protein. PUB1 has been identified as both, a heterogeneous nuclear RNA-binding protein (hnRNP) and a cytoplasmic mRNA-binding protein (mRNP), which may be stably bound to a translationally inactive subpopulation of mRNAs within the cytoplasm. It is distributed in both, the nucleus and the cytoplasm, and binds to poly(A)+ RNA (mRNA or pre-mRNA). Although it is one of the major cellular proteins cross-linked by UV light to polyadenylated RNAs in vivo, PUB1 is nonessential for cell growth in yeast. PUB1 also binds to T-rich single stranded DNA (ssDNA). However, there is no strong evidence implicating PUB1 in the mechanism of DNA replication. PUB1 contains three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and a GAR motif (glycine and arginine rich stretch) that is located between RRM2 and RRM3. [[cite:PUB00083343], [cite:PUB00083813], [cite:PUB00127656], [cite:PUB00083646], [cite:PUB00079469], [cite:PUB00079470]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00083343": {
"PMID": 8413212,
"ISBN": null,
"volume": "13",
"issue": "10",
"year": 1993,
"title": "PUB1 is a major nuclear and cytoplasmic polyadenylated RNA-binding protein in Saccharomyces cerevisiae.",
"URL": null,
"raw_pages": "6102-13",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Anderson JT",
"Paddy MR",
"Swanson MS."
],
"DOI_URL": "http://dx.doi.org/10.1128/MCB.13.10.6102"
},
"PUB00083813": {
"PMID": 8413213,
"ISBN": null,
"volume": "13",
"issue": "10",
"year": 1993,
"title": "PUB1: a major yeast poly(A)+ RNA-binding protein.",
"URL": null,
"raw_pages": "6114-23",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Matunis MJ",
"Matunis EL",
"Dreyfuss G."
],
"DOI_URL": "http://dx.doi.org/10.1128/MCB.13.10.6114"
},
"PUB00079470": {
"PMID": 22278943,
"ISBN": null,
"volume": "3",
"issue": "2",
"year": 2012,
"title": "Structural insight into RNA recognition motifs: versatile molecular Lego building blocks for biological systems.",
"URL": null,
"raw_pages": "229-46",
"medline_journal": "Wiley Interdiscip Rev RNA",
"ISO_journal": "Wiley Interdiscip Rev RNA",
"authors": [
"Muto Y",
"Yokoyama S."
],
"DOI_URL": "http://dx.doi.org/10.1002/wrna.1107"
},
"PUB00083646": {
"PMID": 8127652,
"ISBN": null,
"volume": "22",
"issue": "1",
"year": 1994,
"title": "The yeast protein encoded by PUB1 binds T-rich single stranded DNA.",
"URL": null,
"raw_pages": "32-40",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res.",
"authors": [
"Cockell M",
"Frutiger S",
"Hughes GJ",
"Gasser SM."
],
"DOI_URL": "http://dx.doi.org/10.1093/nar/22.1.32"
},
"PUB00079469": {
"PMID": 22516180,
"ISBN": null,
"volume": "22",
"issue": "3",
"year": 2012,
"title": "Dynamics in multi-domain protein recognition of RNA.",
"URL": null,
"raw_pages": "287-96",
"medline_journal": "Curr Opin Struct Biol",
"ISO_journal": "Curr. Opin. Struct. Biol.",
"authors": [
"Mackereth CD",
"Sattler M."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.sbi.2012.03.013"
},
"PUB00127656": {
"PMID": 8341595,
"ISBN": null,
"volume": "21",
"issue": "14",
"year": 1993,
"title": "A protein containing conserved RNA-recognition motifs is associated with ribosomal subunits in Saccharomyces cerevisiae.",
"URL": null,
"raw_pages": "3211-6",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res",
"authors": [
"Ripmaster TL",
"Woolford JL Jr."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl17169",
"name": "RRM_SF"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 3155,
"pathways": 0,
"proteins": 3153,
"proteomes": 1507,
"sets": 1,
"structural_models": {
"alphafold": 2729,
"bfvd": 0
},
"structures": 2,
"taxa": 3586
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "3md1",
"name": "Crystal Structure of the Second RRM Domain of Yeast Poly(U)-Binding Protein (Pub1)"
}
}
}
