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{
"metadata": {
"accession": "cd12574",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": "IPR034134",
"hierarchy": null,
"name": {
"name": "RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins",
"short": "RRM1_DAZAP1"
},
"description": [
{
"text": "<p>This subfamily corresponds to the RRM1 of DAZAP1 or DAZ-associated protein 1, also termed proline-rich RNA binding protein (Prrp), a multi-functional ubiquitous RNA-binding protein expressed most abundantly in the testis and essential for normal cell growth, development, and spermatogenesis. DAZAP1 is a shuttling protein whose acetylated form is predominantly nuclear and the nonacetylated form is in cytoplasm. It also functions as a translational regulator that activates translation in an mRNA-specific manner. DAZAP1 was initially identified as a binding partner of Deleted in Azoospermia (DAZ). It also interacts with numerous hnRNPs, including hnRNP U, hnRNP U like-1, hnRNPA1, hnRNPA/B, and hnRNP D, suggesting DAZAP1 might associate and cooperate with hnRNP particles to regulate adenylate-uridylate-rich elements (AU-rich element or ARE)-containing mRNAs. DAZAP1 contains two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and a C-terminal proline-rich domain. [[cite:PUB00053781], [cite:PUB00129444], [cite:PUB00082729], [cite:PUB00082733], [cite:PUB00082730], [cite:PUB00129445], [cite:PUB00082732], [cite:PUB00129446], [cite:PUB00082731], [cite:PUB00079469], [cite:PUB00079470]]</p>",
"llm": false,
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}
],
"wikipedia": null,
"literature": {
"PUB00082729": {
"PMID": 21576381,
"ISBN": null,
"volume": "17",
"issue": "7",
"year": 2011,
"title": "DAZAP1, an RNA-binding protein required for development and spermatogenesis, can regulate mRNA translation.",
"URL": null,
"raw_pages": "1282-95",
"medline_journal": "RNA",
"ISO_journal": "RNA",
"authors": [
"Smith RW",
"Anderson RC",
"Smith JW",
"Brook M",
"Richardson WA",
"Gray NK."
],
"DOI_URL": "http://dx.doi.org/10.1261/rna.2717711"
},
"PUB00053781": {
"PMID": 10857750,
"ISBN": null,
"volume": "65",
"issue": "3",
"year": 2000,
"title": "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.",
"URL": null,
"raw_pages": "266-73",
"medline_journal": "Genomics",
"ISO_journal": "Genomics",
"authors": [
"Tsui S",
"Dai T",
"Roettger S",
"Schempp W",
"Salido EC",
"Yen PH."
],
"DOI_URL": "http://dx.doi.org/10.1006/geno.2000.6169"
},
"PUB00082732": {
"PMID": 16772659,
"ISBN": null,
"volume": "12",
"issue": "8",
"year": 2006,
"title": "A novel nucleocytoplasmic shuttling sequence of DAZAP1, a testis-abundant RNA-binding protein.",
"URL": null,
"raw_pages": "1486-93",
"medline_journal": "RNA",
"ISO_journal": "RNA",
"authors": [
"Lin YT",
"Yen PH."
],
"DOI_URL": "http://dx.doi.org/10.1261/rna.42206"
},
"PUB00079470": {
"PMID": 22278943,
"ISBN": null,
"volume": "3",
"issue": "2",
"year": 2012,
"title": "Structural insight into RNA recognition motifs: versatile molecular Lego building blocks for biological systems.",
"URL": null,
"raw_pages": "229-46",
"medline_journal": "Wiley Interdiscip Rev RNA",
"ISO_journal": "Wiley Interdiscip Rev RNA",
"authors": [
"Muto Y",
"Yokoyama S."
],
"DOI_URL": "http://dx.doi.org/10.1002/wrna.1107"
},
"PUB00079469": {
"PMID": 22516180,
"ISBN": null,
"volume": "22",
"issue": "3",
"year": 2012,
"title": "Dynamics in multi-domain protein recognition of RNA.",
"URL": null,
"raw_pages": "287-96",
"medline_journal": "Curr Opin Struct Biol",
"ISO_journal": "Curr. Opin. Struct. Biol.",
"authors": [
"Mackereth CD",
"Sattler M."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.sbi.2012.03.013"
},
"PUB00129444": {
"PMID": 22001406,
"ISBN": null,
"volume": "491",
"issue": "1",
"year": 2012,
"title": "Acetylation of Prrp K150 regulates the subcellular localization.",
"URL": null,
"raw_pages": "13-9",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Sasaki K",
"Suzuki A",
"Kagatsume S",
"Ono M",
"Matsuzawa K",
"Taguchi Y",
"Kurihara Y."
],
"DOI_URL": null
},
"PUB00129445": {
"PMID": 16848763,
"ISBN": null,
"volume": "399",
"issue": "2",
"year": 2006,
"title": "Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ.",
"URL": null,
"raw_pages": "265-73",
"medline_journal": "Biochem J",
"ISO_journal": "Biochem J",
"authors": [
"Morton S",
"Yang HT",
"Moleleki N",
"Campbell DG",
"Cohen P",
"Rousseau S."
],
"DOI_URL": null
},
"PUB00129446": {
"PMID": 15647502,
"ISBN": null,
"volume": "33",
"issue": "1",
"year": 2005,
"title": "The RNA ligands for mouse proline-rich RNA-binding protein (mouse Prrp) contain two consensus sequences in separate loop structure.",
"URL": null,
"raw_pages": "190-200",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res",
"authors": [
"Hori T",
"Taguchi Y",
"Uesugi S",
"Kurihara Y."
],
"DOI_URL": null
},
"PUB00082733": {
"PMID": 19285026,
"ISBN": null,
"volume": "380",
"issue": "3",
"year": 2009,
"title": "DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins.",
"URL": null,
"raw_pages": "705-9",
"medline_journal": "Biochem Biophys Res Commun",
"ISO_journal": "Biochem. Biophys. Res. Commun.",
"authors": [
"Yang HT",
"Peggie M",
"Cohen P",
"Rousseau S."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.bbrc.2009.01.166"
},
"PUB00082731": {
"PMID": 11604102,
"ISBN": null,
"volume": "2",
"issue": null,
"year": 2001,
"title": "Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL.",
"URL": null,
"raw_pages": "6",
"medline_journal": "BMC Genomics",
"ISO_journal": "BMC Genomics",
"authors": [
"Dai T",
"Vera Y",
"Salido EC",
"Yen PH."
],
"DOI_URL": "http://dx.doi.org/10.1186/1471-2164-2-6"
},
"PUB00082730": {
"PMID": 18669443,
"ISBN": null,
"volume": "14",
"issue": "9",
"year": 2008,
"title": "DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice.",
"URL": null,
"raw_pages": "1814-22",
"medline_journal": "RNA",
"ISO_journal": "RNA",
"authors": [
"Hsu LC",
"Chen HY",
"Lin YW",
"Chu WC",
"Lin MJ",
"Yan YT",
"Yen PH."
],
"DOI_URL": "http://dx.doi.org/10.1261/rna.1152808"
}
},
"set_info": {
"accession": "cl17169",
"name": "RRM_SF"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 993,
"pathways": 0,
"proteins": 993,
"proteomes": 352,
"sets": 1,
"structural_models": {
"alphafold": 904,
"bfvd": 0
},
"structures": 1,
"taxa": 1284
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
