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{
"metadata": {
"accession": "cd12535",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": null,
"hierarchy": null,
"name": {
"name": "RNA recognition motif (RRM) found in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins",
"short": "RRM_FUS_TAF15"
},
"description": [
{
"text": "<p>This subgroup corresponds to the RRM of FUS and TAF15. FUS (TLS or Pigpen or hnRNP P2), also termed 75 kDa DNA-pairing protein (POMp75), or oncoprotein TLS (Translocated in liposarcoma), is a member of the FET (previously TET) (FUS/TLS, EWS, TAF15) family of RNA- and DNA-binding proteins whose expression is altered in cancer. It is a multi-functional protein and has been implicated in pre-mRNA splicing, chromosome stability, cell spreading, and transcription. FUS was originally identified in human myxoid and round cell liposarcomas as an oncogenic fusion with the stress-induced DNA-binding transcription factor CHOP (CCAAT enhancer-binding homologous protein) and later as hnRNP P2, a component of hnRNP H complex assembled on pre-mRNA. It can form ternary complexes with hnRNP A1 and hnRNP C1/C2. Additional research indicates that FUS binds preferentially to GGUG-containing RNAs. In the presence of Mg2+, it can bind both single- and double-stranded DNA (ssDNA/dsDNA) and promote ATP-independent annealing of complementary ssDNA and D-loop formation in superhelical dsDNA. FUS has been shown to be recruited by single stranded noncoding RNAs to the regulatory regions of target genes such as cyclin D1, where it represses transcription by disrupting complex formation. TAF15 (TAFII68), also termed TATA-binding protein-associated factor 2N (TAF2N), or RNA-binding protein 56 (RBP56), originally identified as a TAF in the general transcription initiation TFIID complex, is a novel RNA/ssDNA-binding protein with homology to the proto-oncoproteins FUS and EWS (also termed EWSR1), belonging to the FET family as well. TAF15 likely functions in RNA polymerase II (RNAP II) transcription by interacting with TFIID and subunits of RNAP II itself. TAF15 is also associated with U1 snRNA, chromatin and RNA, in a complex distinct from the Sm-containing U1 snRNP that functions in splicing. Like other members in the FET family, both FUS and TAF15 contain an N-terminal Ser, Gly, Gln and Tyr-rich region composed of multiple copies of a degenerate hexapeptide repeat motif. The C-terminal region consists of a conserved nuclear import and retention signal (C-NLS), a C2/C2 zinc-finger motif, a conserved RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and at least 1 arginine-glycine-glycine (RGG)-repeat region. [[cite:PUB00084544], [cite:PUB00084547], [cite:PUB00129376], [cite:PUB00129374], [cite:PUB00129373], [cite:PUB00129378], [cite:PUB00129354], [cite:PUB00129379], [cite:PUB00129380], [cite:PUB00129381], [cite:PUB00129382], [cite:PUB00129383], [cite:PUB00123176], [cite:PUB00129384], [cite:PUB00129385], [cite:PUB00129386], [cite:PUB00129387], [cite:PUB00129375], [cite:PUB00129388], [cite:PUB00129389], [cite:PUB00079469], [cite:PUB00079470]]</p>",
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"PUB00129381": {
"PMID": 21921521,
"ISBN": null,
"volume": "50",
"issue": "11",
"year": 2010,
"title": "[FUS/TLS as a polyglutamine aggregate interacting protein].",
"URL": null,
"raw_pages": "945-7",
"medline_journal": "Rinsho Shinkeigaku",
"ISO_journal": "Rinsho Shinkeigaku",
"authors": [
"Nukina N."
],
"DOI_URL": null
},
"PUB00084544": {
"PMID": 19124016,
"ISBN": null,
"volume": "315",
"issue": "7",
"year": 2009,
"title": "PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function.",
"URL": null,
"raw_pages": "1273-86",
"medline_journal": "Exp Cell Res",
"ISO_journal": "Exp. Cell Res.",
"authors": [
"Jobert L",
"Argentini M",
"Tora L."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.yexcr.2008.12.008"
},
"PUB00129389": {
"PMID": 8510758,
"ISBN": null,
"volume": "363",
"issue": "6430",
"year": 1993,
"title": "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.",
"URL": null,
"raw_pages": "640-4",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Crozat A",
"Aman P",
"Mandahl N",
"Ron D."
],
"DOI_URL": null
},
"PUB00129373": {
"PMID": 8954779,
"ISBN": null,
"volume": "38",
"issue": "1",
"year": 1996,
"title": "Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins.",
"URL": null,
"raw_pages": "51-7",
"medline_journal": "Genomics",
"ISO_journal": "Genomics",
"authors": [
"Morohoshi F",
"Arai K",
"Takahashi EI",
"Tanigami A",
"Ohki M."
],
"DOI_URL": null
},
"PUB00129382": {
"PMID": 19251628,
"ISBN": null,
"volume": "323",
"issue": "5918",
"year": 2009,
"title": "Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.",
"URL": null,
"raw_pages": "1208-1211",
"medline_journal": "Science",
"ISO_journal": "Science",
"authors": [
"Vance C",
"Rogelj B",
"Hortobagyi T",
"De Vos KJ",
"Nishimura AL",
"Sreedharan J",
"Hu X",
"Smith B",
"Ruddy D",
"Wright P",
"Ganesalingam J",
"Williams KL",
"Tripathi V",
"Al-Saraj S",
"Al-Chalabi A",
"Leigh PN",
"Blair IP",
"Nicholson G",
"de Belleroche J",
"Gallo JM",
"Miller CC",
"Shaw CE."
],
"DOI_URL": null
},
"PUB00129378": {
"PMID": 21169411,
"ISBN": null,
"volume": "71",
"issue": "3",
"year": 2011,
"title": "FUS/TLS is a novel mediator of androgen-dependent cell-cycle progression and prostate cancer growth.",
"URL": null,
"raw_pages": "914-24",
"medline_journal": "Cancer Res",
"ISO_journal": "Cancer Res",
"authors": [
"Brooke GN",
"Culley RL",
"Dart DA",
"Mann DJ",
"Gaughan L",
"McCracken SR",
"Robson CN",
"Spencer-Dene B",
"Gamble SC",
"Powell SM",
"Wait R",
"Waxman J",
"Walker MM",
"Bevan CL."
],
"DOI_URL": null
},
"PUB00084547": {
"PMID": 21438137,
"ISBN": null,
"volume": "156B",
"issue": "3",
"year": 2011,
"title": "Mutational analysis reveals the FUS homolog TAF15 as a candidate gene for familial amyotrophic lateral sclerosis.",
"URL": null,
"raw_pages": "285-90",
"medline_journal": "Am J Med Genet B Neuropsychiatr Genet",
"ISO_journal": "Am. J. Med. Genet. B Neuropsychiatr. Genet.",
"authors": [
"Ticozzi N",
"Vance C",
"Leclerc AL",
"Keagle P",
"Glass JD",
"McKenna-Yasek D",
"Sapp PC",
"Silani V",
"Bosco DA",
"Shaw CE",
"Brown RH Jr",
"Landers JE."
],
"DOI_URL": "http://dx.doi.org/10.1002/ajmg.b.31158"
},
"PUB00129385": {
"PMID": 10442642,
"ISBN": null,
"volume": "18",
"issue": "31",
"year": 1999,
"title": "Human POMp75 is identified as the pro-oncoprotein TLS/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation.",
"URL": null,
"raw_pages": "4515-21",
"medline_journal": "Oncogene",
"ISO_journal": "Oncogene",
"authors": [
"Bertrand P",
"Akhmedov AT",
"Delacote F",
"Durrbach A",
"Lopez BS."
],
"DOI_URL": null
},
"PUB00129379": {
"PMID": 21915790,
"ISBN": null,
"volume": "722",
"issue": null,
"year": 2011,
"title": "Promoter-associated long noncoding RNAs repress transcription through a RNA binding protein TLS.",
"URL": null,
"raw_pages": "196-208",
"medline_journal": "Adv Exp Med Biol",
"ISO_journal": "Adv Exp Med Biol",
"authors": [
"Kurokawa R."
],
"DOI_URL": null
},
"PUB00123176": {
"PMID": 8187069,
"ISBN": null,
"volume": "54",
"issue": "11",
"year": 1994,
"title": "An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.",
"URL": null,
"raw_pages": "2865-8",
"medline_journal": "Cancer Res",
"ISO_journal": "Cancer Res",
"authors": [
"Ichikawa H",
"Shimizu K",
"Hayashi Y",
"Ohki M."
],
"DOI_URL": null
},
"PUB00079469": {
"PMID": 22516180,
"ISBN": null,
"volume": "22",
"issue": "3",
"year": 2012,
"title": "Dynamics in multi-domain protein recognition of RNA.",
"URL": null,
"raw_pages": "287-96",
"medline_journal": "Curr Opin Struct Biol",
"ISO_journal": "Curr. Opin. Struct. Biol.",
"authors": [
"Mackereth CD",
"Sattler M."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.sbi.2012.03.013"
},
"PUB00129383": {
"PMID": 19251627,
"ISBN": null,
"volume": "323",
"issue": "5918",
"year": 2009,
"title": "Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.",
"URL": null,
"raw_pages": "1205-8",
"medline_journal": "Science",
"ISO_journal": "Science",
"authors": [
"Kwiatkowski TJ Jr",
"Bosco DA",
"Leclerc AL",
"Tamrazian E",
"Vanderburg CR",
"Russ C",
"Davis A",
"Gilchrist J",
"Kasarskis EJ",
"Munsat T",
"Valdmanis P",
"Rouleau GA",
"Hosler BA",
"Cortelli P",
"de Jong PJ",
"Yoshinaga Y",
"Haines JL",
"Pericak-Vance MA",
"Yan J",
"Ticozzi N",
"Siddique T",
"McKenna-Yasek D",
"Sapp PC",
"Horvitz HR",
"Landers JE",
"Brown RH Jr."
],
"DOI_URL": null
},
"PUB00129375": {
"PMID": 9795213,
"ISBN": null,
"volume": "221",
"issue": "2",
"year": 1998,
"title": "Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.",
"URL": null,
"raw_pages": "191-8",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Morohoshi F",
"Ootsuka Y",
"Arai K",
"Ichikawa H",
"Mitani S",
"Munakata N",
"Ohki M."
],
"DOI_URL": null
},
"PUB00129380": {
"PMID": 20124201,
"ISBN": null,
"volume": "74",
"issue": "5",
"year": 2010,
"title": "Genetic contribution of FUS to frontotemporal lobar degeneration.",
"URL": null,
"raw_pages": "366-71",
"medline_journal": "Neurology",
"ISO_journal": "Neurology",
"authors": [
"Van Langenhove T",
"van der Zee J",
"Sleegers K",
"Engelborghs S",
"Vandenberghe R",
"Gijselinck I",
"Van den Broeck M",
"Mattheijssens M",
"Peeters K",
"De Deyn PP",
"Cruts M",
"Van Broeckhoven C."
],
"DOI_URL": null
},
"PUB00129384": {
"PMID": 9774382,
"ISBN": null,
"volume": "273",
"issue": "43",
"year": 1998,
"title": "Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing.",
"URL": null,
"raw_pages": "27761-4",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Yang L",
"Embree LJ",
"Tsai S",
"Hickstein DD."
],
"DOI_URL": null
},
"PUB00129354": {
"PMID": 21197473,
"ISBN": null,
"volume": "2011",
"issue": null,
"year": 2011,
"title": "Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family.",
"URL": null,
"raw_pages": "837474",
"medline_journal": "Sarcoma",
"ISO_journal": "Sarcoma",
"authors": [
"Kovar H."
],
"DOI_URL": null
},
"PUB00129387": {
"PMID": 11063792,
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"volume": "121",
"issue": "2",
"year": 2000,
"title": "Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11.",
"URL": null,
"raw_pages": "109-16",
"medline_journal": "Cancer Genet Cytogenet",
"ISO_journal": "Cancer Genet Cytogenet",
"authors": [
"Waters BL",
"Panagopoulos I",
"Allen EF."
],
"DOI_URL": null
},
"PUB00079470": {
"PMID": 22278943,
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"volume": "3",
"issue": "2",
"year": 2012,
"title": "Structural insight into RNA recognition motifs: versatile molecular Lego building blocks for biological systems.",
"URL": null,
"raw_pages": "229-46",
"medline_journal": "Wiley Interdiscip Rev RNA",
"ISO_journal": "Wiley Interdiscip Rev RNA",
"authors": [
"Muto Y",
"Yokoyama S."
],
"DOI_URL": "http://dx.doi.org/10.1002/wrna.1107"
},
"PUB00129376": {
"PMID": 7708500,
"ISBN": null,
"volume": "23",
"issue": "5",
"year": 1995,
"title": "Cabeza, a Drosophila gene encoding a novel RNA binding protein, shares homology with EWS and TLS, two genes involved in human sarcoma formation.",
"URL": null,
"raw_pages": "835-43",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res",
"authors": [
"Stolow DT",
"Haynes SR."
],
"DOI_URL": null
},
"PUB00129386": {
"PMID": 10567410,
"ISBN": null,
"volume": "274",
"issue": "48",
"year": 1999,
"title": "Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation.",
"URL": null,
"raw_pages": "34337-42",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Baechtold H",
"Kuroda M",
"Sok J",
"Ron D",
"Lopez BS",
"Akhmedov AT."
],
"DOI_URL": null
},
"PUB00129388": {
"PMID": 7503811,
"ISBN": null,
"volume": "4",
"issue": "2",
"year": 1993,
"title": "Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.",
"URL": null,
"raw_pages": "175-80",
"medline_journal": "Nat Genet",
"ISO_journal": "Nat Genet",
"authors": [
"Rabbitts TH",
"Forster A",
"Larson R",
"Nathan P."
],
"DOI_URL": null
},
"PUB00129374": {
"PMID": 8890175,
"ISBN": null,
"volume": "15",
"issue": "18",
"year": 1996,
"title": "hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II.",
"URL": null,
"raw_pages": "5022-31",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J",
"authors": [
"Bertolotti A",
"Lutz Y",
"Heard DJ",
"Chambon P",
"Tora L."
],
"DOI_URL": null
}
},
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"structural_models": {
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"taxa": 2085
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}
