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{
"metadata": {
"accession": "cd12531",
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"type": "domain",
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"source_database": "cdd",
"member_databases": null,
"integrated": "IPR034454",
"hierarchy": null,
"name": {
"name": "RNA recognition motif 3 (RRM3) found in plant Mei2-like proteins",
"short": "RRM3_MEI2_like"
},
"description": [
{
"text": "<p>This subgroup corresponds to the RRM3 of Mei2-like proteins, representing an ancient eukaryotic RNA-binding proteins family. Their corresponding Mei2-like genes appear to have arisen early in eukaryote evolution, been lost from some lineages such as Saccharomyces cerevisiae and metazoans, and diversified in the plant lineage. The plant Mei2-like genes may function in cell fate specification during development, rather than as stimulators of meiosis. Members in this family contain three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). The C-terminal RRM (RRM3) is unique to Mei2-like proteins and is highly conserved between plants and fungi. To date, the intracellular localization, RNA target(s), cellular interactions and phosphorylation states of Mei2-like proteins in plants remain unclear. [[cite:PUB00020274], [cite:PUB00083568], [cite:PUB00083569], [cite:PUB00083567], [cite:PUB00083566], [cite:PUB00079469], [cite:PUB00079470]]</p>",
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],
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"literature": {
"PUB00083569": {
"PMID": 16473967,
"ISBN": null,
"volume": "18",
"issue": "3",
"year": 2006,
"title": "The Arabidopsis-mei2-like genes play a role in meiosis and vegetative growth in Arabidopsis.",
"URL": null,
"raw_pages": "545-59",
"medline_journal": "Plant Cell",
"ISO_journal": "Plant Cell",
"authors": [
"Kaur J",
"Sebastian J",
"Siddiqi I."
],
"DOI_URL": "http://dx.doi.org/10.1105/tpc.105.039156"
},
"PUB00083568": {
"PMID": 15720729,
"ISBN": null,
"volume": "5",
"issue": null,
"year": 2005,
"title": "The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B, the plant homologue of a major regulator of eukaryotic cell growth.",
"URL": null,
"raw_pages": "2",
"medline_journal": "BMC Plant Biol",
"ISO_journal": "BMC Plant Biol.",
"authors": [
"Anderson GH",
"Hanson MR."
],
"DOI_URL": "http://dx.doi.org/10.1186/1471-2229-5-2"
},
"PUB00079470": {
"PMID": 22278943,
"ISBN": null,
"volume": "3",
"issue": "2",
"year": 2012,
"title": "Structural insight into RNA recognition motifs: versatile molecular Lego building blocks for biological systems.",
"URL": null,
"raw_pages": "229-46",
"medline_journal": "Wiley Interdiscip Rev RNA",
"ISO_journal": "Wiley Interdiscip Rev RNA",
"authors": [
"Muto Y",
"Yokoyama S."
],
"DOI_URL": "http://dx.doi.org/10.1002/wrna.1107"
},
"PUB00079469": {
"PMID": 22516180,
"ISBN": null,
"volume": "22",
"issue": "3",
"year": 2012,
"title": "Dynamics in multi-domain protein recognition of RNA.",
"URL": null,
"raw_pages": "287-96",
"medline_journal": "Curr Opin Struct Biol",
"ISO_journal": "Curr. Opin. Struct. Biol.",
"authors": [
"Mackereth CD",
"Sattler M."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.sbi.2012.03.013"
},
"PUB00083567": {
"PMID": 15356386,
"ISBN": null,
"volume": "54",
"issue": "5",
"year": 2004,
"title": "Diversification of genes encoding mei2 -like RNA binding proteins in plants.",
"URL": null,
"raw_pages": "653-70",
"medline_journal": "Plant Mol Biol",
"ISO_journal": "Plant Mol. Biol.",
"authors": [
"Anderson GH",
"Alvarez ND",
"Gilman C",
"Jeffares DC",
"Trainor VC",
"Hanson MR",
"Veit B."
],
"DOI_URL": "http://dx.doi.org/10.1023/B:PLAN.0000040819.33383.b6"
},
"PUB00083566": {
"PMID": 9287109,
"ISBN": null,
"volume": "413",
"issue": "1",
"year": 1997,
"title": "Functional cloning of a cDNA encoding Mei2-like protein from Arabidopsis thaliana using a fission yeast pheromone receptor deficient mutant.",
"URL": null,
"raw_pages": "16-20",
"medline_journal": "FEBS Lett",
"ISO_journal": "FEBS Lett.",
"authors": [
"Hirayama T",
"Ishida C",
"Kuromori T",
"Obata S",
"Shimoda C",
"Yamamoto M",
"Shinozaki K",
"Ohto C."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0014-5793(97)00871-5"
},
"PUB00020274": {
"PMID": 14986133,
"ISBN": null,
"volume": "214",
"issue": "3",
"year": 2004,
"title": "A description of the Mei2-like protein family; structure, phylogenetic distribution and biological context.",
"URL": null,
"raw_pages": "149-58",
"medline_journal": "Dev Genes Evol",
"ISO_journal": "Dev. Genes Evol.",
"authors": [
"Jeffares DC",
"Phillips MJ",
"Moore S",
"Veit B."
],
"DOI_URL": "http://dx.doi.org/10.1007/s00427-004-0384-6"
}
},
"set_info": {
"accession": "cl17169",
"name": "RRM_SF"
},
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"subfamilies": 0,
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"interactions": 0,
"matches": 3218,
"pathways": 0,
"proteins": 3217,
"proteomes": 488,
"sets": 1,
"structural_models": {
"alphafold": 2752,
"bfvd": 0
},
"structures": 0,
"taxa": 1533
},
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"cross_references": {},
"is_llm": false,
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"representative_structure": null
}
}
