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{
"metadata": {
"accession": "cd12283",
"entry_id": null,
"type": "domain",
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"source_database": "cdd",
"member_databases": null,
"integrated": null,
"hierarchy": null,
"name": {
"name": "RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 39 (RBM39) and similar proteins",
"short": "RRM1_RBM39_like"
},
"description": [
{
"text": "<p>This subfamily corresponds to the RRM1 of RNA-binding protein 39 (RBM39), RNA-binding protein 23 (RBM23) and similar proteins. RBM39 (also termed HCC1) is a nuclear autoantigen that contains an N-terminal arginine/serine rich (RS) motif and three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). An octapeptide sequence called the RS-ERK motif is repeated six times in the RS region of RBM39. Although the cellular function of RBM23 remains unclear, it shows high sequence homology to RBM39 and contains two RRMs. It may possibly function as a pre-mRNA splicing factor. [[cite:PUB00017723], [cite:PUB00083775], [cite:PUB00079469], [cite:PUB00079470]]</p>",
"llm": false,
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}
],
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"literature": {
"PUB00079470": {
"PMID": 22278943,
"ISBN": null,
"volume": "3",
"issue": "2",
"year": 2012,
"title": "Structural insight into RNA recognition motifs: versatile molecular Lego building blocks for biological systems.",
"URL": null,
"raw_pages": "229-46",
"medline_journal": "Wiley Interdiscip Rev RNA",
"ISO_journal": "Wiley Interdiscip Rev RNA",
"authors": [
"Muto Y",
"Yokoyama S."
],
"DOI_URL": "http://dx.doi.org/10.1002/wrna.1107"
},
"PUB00079469": {
"PMID": 22516180,
"ISBN": null,
"volume": "22",
"issue": "3",
"year": 2012,
"title": "Dynamics in multi-domain protein recognition of RNA.",
"URL": null,
"raw_pages": "287-96",
"medline_journal": "Curr Opin Struct Biol",
"ISO_journal": "Curr. Opin. Struct. Biol.",
"authors": [
"Mackereth CD",
"Sattler M."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.sbi.2012.03.013"
},
"PUB00017723": {
"PMID": 8227358,
"ISBN": null,
"volume": "92",
"issue": "5",
"year": 1993,
"title": "Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma.",
"URL": null,
"raw_pages": "2419-26",
"medline_journal": "J Clin Invest",
"ISO_journal": "J. Clin. Invest.",
"authors": [
"Imai H",
"Chan EK",
"Kiyosawa K",
"Fu XD",
"Tan EM."
],
"DOI_URL": "http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=8227358&action=stream&blobtype=pdf"
},
"PUB00083775": {
"PMID": 15798186,
"ISBN": null,
"volume": "25",
"issue": "8",
"year": 2005,
"title": "A novel SR-related protein is required for the second step of Pre-mRNA splicing.",
"URL": null,
"raw_pages": "2969-80",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Cazalla D",
"Newton K",
"Caceres JF."
],
"DOI_URL": "http://dx.doi.org/10.1128/MCB.25.8.2969-2980.2005"
}
},
"set_info": {
"accession": "cl17169",
"name": "RRM_SF"
},
"overlaps_with": null,
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"subfamilies": 0,
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"matches": 3531,
"pathways": 0,
"proteins": 3529,
"proteomes": 1800,
"sets": 1,
"structural_models": {
"alphafold": 3086,
"bfvd": 0
},
"structures": 0,
"taxa": 5116
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
