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{
"metadata": {
"accession": "cd12142",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": "IPR035468",
"hierarchy": null,
"name": {
"name": "Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins",
"short": "SH3_D21-like"
},
"description": [
{
"text": "<p>N-terminal SH3 domain of the uncharacterized protein SH3 domain-containing protein 21, and similar uncharacterized domains, it belongs to the CD2AP-like_3 subfamily of proteins. The CD2AP-like_3 subfamily is composed of the third SH3 domain (SH3C) of CD2AP, CIN85 (Cbl-interacting protein of 85 kDa), and similar domains. CD2AP and CIN85 are adaptor proteins that bind to protein partners and assemble complexes that have been implicated in T cell activation, kidney function, and apoptosis of neuronal cells. They also associate with endocytic proteins, actin cytoskeleton components, and other adaptor proteins involved in receptor tyrosine kinase (RTK) signaling. CD2AP and the main isoform of CIN85 contain three SH3 domains, a proline-rich region, and a C-terminal coiled-coil domain. All of these domains enable CD2AP and CIN85 to bind various protein partners and assemble complexes that have been implicated in many different functions. SH3C of both proteins have been shown to bind to ubiquitin. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies. [[cite:PUB00127768], [cite:PUB00048075], [cite:PUB00127769], [cite:PUB00127770], [cite:PUB00068592], [cite:PUB00086158], [cite:PUB00086157], [cite:PUB00086155], [cite:PUB00086160], [cite:PUB00048247], [cite:PUB00127771], [cite:PUB00127772], [cite:PUB00127773], [cite:PUB00086161], [cite:PUB00127774], [cite:PUB00127775], [cite:PUB00127776], [cite:PUB00127777], [cite:PUB00127778], [cite:PUB00057202], [cite:PUB00127779], [cite:PUB00127780], [cite:PUB00127781], [cite:PUB00085556], [cite:PUB00085557], [cite:PUB00085558], [cite:PUB00085559], [cite:PUB00007145], [cite:PUB00007124]]</p>",
"llm": false,
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}
],
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"PMID": 22203040,
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"volume": "32",
"issue": "6",
"year": 2012,
"title": "CD2AP regulates SUMOylation of CIN85 in podocytes.",
"URL": null,
"raw_pages": "1068-79",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol Cell Biol",
"authors": [
"Tossidou I",
"Niedenthal R",
"Klaus M",
"Teng B",
"Worthmann K",
"King BL",
"Peterson KJ",
"Haller H",
"Schiffer M."
],
"DOI_URL": null
},
"PUB00086155": {
"PMID": 22262777,
"ISBN": null,
"volume": "119",
"issue": "10",
"year": 2012,
"title": "CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells.",
"URL": null,
"raw_pages": "2263-73",
"medline_journal": "Blood",
"ISO_journal": "Blood",
"authors": [
"Niiro H",
"Jabbarzadeh-Tabrizi S",
"Kikushige Y",
"Shima T",
"Noda K",
"Ota S",
"Tsuzuki H",
"Inoue Y",
"Arinobu Y",
"Iwasaki H",
"Shimoda S",
"Baba E",
"Tsukamoto H",
"Horiuchi T",
"Taniyama T",
"Akashi K."
],
"DOI_URL": "https://doi.org/10.1182/blood-2011-04-351965"
},
"PUB00127768": {
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"ISBN": null,
"volume": "50",
"issue": "18",
"year": 2011,
"title": "Making ends meet: the importance of the N- and C-termini for the structure, stability, and function of the third SH3 domain of CIN85.",
"URL": null,
"raw_pages": "3649-59",
"medline_journal": "Biochemistry",
"ISO_journal": "Biochemistry",
"authors": [
"Philippe D",
"Ababou A",
"Yang X",
"Ghosh R",
"Daviter T",
"Ladbury JE",
"Pfuhl M."
],
"DOI_URL": null
},
"PUB00127776": {
"PMID": 21911934,
"ISBN": null,
"volume": "121",
"issue": "10",
"year": 2011,
"title": "CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.",
"URL": null,
"raw_pages": "3965-80",
"medline_journal": "J Clin Invest",
"ISO_journal": "J Clin Invest",
"authors": [
"Yaddanapudi S",
"Altintas MM",
"Kistler AD",
"Fernandez I",
"Moller CC",
"Wei C",
"Peev V",
"Flesche JB",
"Forst AL",
"Li J",
"Patrakka J",
"Xiao Z",
"Grahammer F",
"Schiffer M",
"Lohmuller T",
"Reinheckel T",
"Gu C",
"Huber TB",
"Ju W",
"Bitzer M",
"Rastaldi MP",
"Ruiz P",
"Tryggvason K",
"Shaw AS",
"Faul C",
"Sever S",
"Reiser J."
],
"DOI_URL": null
},
"PUB00057202": {
"PMID": 16751601,
"ISBN": null,
"volume": "139",
"issue": "5",
"year": 2006,
"title": "CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin.",
"URL": null,
"raw_pages": "931-9",
"medline_journal": "J Biochem",
"ISO_journal": "J. Biochem.",
"authors": [
"Kawata A",
"Iida J",
"Ikeda M",
"Sato Y",
"Mori H",
"Kansaku A",
"Sumita K",
"Fujiwara N",
"Rokukawa C",
"Hamano M",
"Hirabayashi S",
"Hata Y."
],
"DOI_URL": "http://dx.doi.org/10.1093/jb/mvj105"
},
"PUB00086161": {
"PMID": 19359362,
"ISBN": null,
"volume": "37",
"issue": "9",
"year": 2009,
"title": "Accurate characterization of weak macromolecular interactions by titration of NMR residual dipolar couplings: application to the CD2AP SH3-C:ubiquitin complex.",
"URL": null,
"raw_pages": "e70",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res.",
"authors": [
"Ortega-Roldan JL",
"Jensen MR",
"Brutscher B",
"Azuaga AI",
"Blackledge M",
"van Nuland NA."
],
"DOI_URL": "https://doi.org/10.1093/nar/gkp211"
},
"PUB00127771": {
"PMID": 17606992,
"ISBN": null,
"volume": "120",
"issue": "Pt 14",
"year": 2007,
"title": "Structure and function analysis of the CMS/CIN85 protein family identifies actin-bundling properties and heterotypic-complex formation.",
"URL": null,
"raw_pages": "2366-77",
"medline_journal": "J Cell Sci",
"ISO_journal": "J Cell Sci",
"authors": [
"Gaidos G",
"Soni S",
"Oswald DJ",
"Toselli PA",
"Kirsch KH."
],
"DOI_URL": null
},
"PUB00085557": {
"PMID": 16134966,
"ISBN": null,
"volume": "390",
"issue": "Pt 3",
"year": 2005,
"title": "Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction.",
"URL": null,
"raw_pages": "641-53",
"medline_journal": "Biochem J",
"ISO_journal": "Biochem. J.",
"authors": [
"Li SS."
],
"DOI_URL": "https://doi.org/10.1042/BJ20050411"
},
"PUB00007145": {
"PMID": 11256992,
"ISBN": null,
"volume": "114",
"issue": "Pt 7",
"year": 2001,
"title": "SH3 domains: complexity in moderation.",
"URL": null,
"raw_pages": "1253-63",
"medline_journal": "J Cell Sci",
"ISO_journal": "J. Cell. Sci.",
"authors": [
"Mayer BJ."
],
"DOI_URL": "http://jcs.biologists.org/cgi/content/abstract/114/7/1253"
},
"PUB00127769": {
"PMID": 14643126,
"ISBN": null,
"volume": "362",
"issue": "9397",
"year": 2003,
"title": "CD2-associated protein and glomerular disease.",
"URL": null,
"raw_pages": "1746-8",
"medline_journal": "Lancet",
"ISO_journal": "Lancet",
"authors": [
"Wolf G",
"Stahl RA."
],
"DOI_URL": null
},
"PUB00127770": {
"PMID": 19816391,
"ISBN": null,
"volume": "61",
"issue": "4",
"year": 2009,
"title": "Immunological and non-immunological mechanisms of proteinuria.",
"URL": null,
"raw_pages": "385-96",
"medline_journal": "Minerva Urol Nefrol",
"ISO_journal": "Minerva Urol Nefrol",
"authors": [
"Braun N",
"Grone HJ",
"Schena FP."
],
"DOI_URL": null
},
"PUB00127781": {
"PMID": 15090612,
"ISBN": null,
"volume": "15",
"issue": "7",
"year": 2004,
"title": "CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors.",
"URL": null,
"raw_pages": "3155-66",
"medline_journal": "Mol Biol Cell",
"ISO_journal": "Mol Biol Cell",
"authors": [
"Kowanetz K",
"Husnjak K",
"Holler D",
"Kowanetz M",
"Soubeyran P",
"Hirsch D",
"Schmidt MHH",
"Pavelic K",
"De Camilli P",
"Randazzo PA",
"Dikic I."
],
"DOI_URL": null
},
"PUB00127775": {
"PMID": 22254144,
"ISBN": null,
"volume": "2011",
"issue": null,
"year": 2011,
"title": "Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System.",
"URL": null,
"raw_pages": "501862",
"medline_journal": "Int J Alzheimers Dis",
"ISO_journal": "Int J Alzheimers Dis",
"authors": [
"Carter C."
],
"DOI_URL": null
},
"PUB00086157": {
"PMID": 12354621,
"ISBN": null,
"volume": "529",
"issue": "1",
"year": 2002,
"title": "CIN85/CMS family of adaptor molecules.",
"URL": null,
"raw_pages": "110-5",
"medline_journal": "FEBS Lett",
"ISO_journal": "FEBS Lett.",
"authors": [
"Dikic I."
],
"DOI_URL": "https://doi.org/10.1016/S0014-5793(02)03188-5"
},
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"ISBN": null,
"volume": "175",
"issue": "7",
"year": 2005,
"title": "CIN85 regulates the ligand-dependent endocytosis of the IgE receptor: a new molecular mechanism to dampen mast cell function.",
"URL": null,
"raw_pages": "4208-16",
"medline_journal": "J Immunol",
"ISO_journal": "J Immunol",
"authors": [
"Molfetta R",
"Belleudi F",
"Peruzzi G",
"Morrone S",
"Leone L",
"Dikic I",
"Piccoli M",
"Frati L",
"Torrisi MR",
"Santoni A",
"Paolini R."
],
"DOI_URL": null
},
"PUB00085559": {
"PMID": 15853651,
"ISBN": null,
"volume": "6",
"issue": "2",
"year": 2005,
"title": "SH3-like fold proteins are structurally conserved and functionally divergent.",
"URL": null,
"raw_pages": "143-50",
"medline_journal": "Curr Protein Pept Sci",
"ISO_journal": "Curr. Protein Pept. Sci.",
"authors": [
"Kishan KV",
"Agrawal V."
],
"DOI_URL": "https://doi.org/10.2174/1389203053545444"
},
"PUB00127773": {
"PMID": 21519904,
"ISBN": null,
"volume": "50",
"issue": "2",
"year": 2011,
"title": "Solution structure, dynamics and thermodynamics of the three SH3 domains of CD2AP.",
"URL": null,
"raw_pages": "103-17",
"medline_journal": "J Biomol NMR",
"ISO_journal": "J Biomol NMR",
"authors": [
"Roldan JL",
"Blackledge M",
"van Nuland NA",
"Azuaga AI."
],
"DOI_URL": null
},
"PUB00068592": {
"PMID": 16889564,
"ISBN": null,
"volume": "11",
"issue": "4",
"year": 2006,
"title": "Role of podocyte slit diaphragm as a filtration barrier.",
"URL": null,
"raw_pages": "274-81",
"medline_journal": "Nephrology (Carlton)",
"ISO_journal": "Nephrology (Carlton)",
"authors": [
"Kawachi H",
"Miyauchi N",
"Suzuki K",
"Han GD",
"Orikasa M",
"Shimizu F."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1440-1797.2006.00583.x"
},
"PUB00085556": {
"PMID": 18508559,
"ISBN": null,
"volume": "13",
"issue": null,
"year": 2008,
"title": "The SH3 domain--a family of versatile peptide- and protein-recognition module.",
"URL": null,
"raw_pages": "4938-52",
"medline_journal": "Front Biosci",
"ISO_journal": "Front. Biosci.",
"authors": [
"Kaneko T",
"Li L",
"Li SS."
],
"DOI_URL": "https://doi.org/10.2741/3053"
},
"PUB00127778": {
"PMID": 16256071,
"ISBN": null,
"volume": "338",
"issue": "2",
"year": 2005,
"title": "CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway.",
"URL": null,
"raw_pages": "808-14",
"medline_journal": "Biochem Biophys Res Commun",
"ISO_journal": "Biochem Biophys Res Commun",
"authors": [
"Aissouni Y",
"Zapart G",
"Iovanna JL",
"Dikic I",
"Soubeyran P."
],
"DOI_URL": null
},
"PUB00127780": {
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"volume": "304",
"issue": "1",
"year": 2005,
"title": "CIN85 associates with TNF receptor 1 via Src and modulates TNF-alpha-induced apoptosis.",
"URL": null,
"raw_pages": "256-64",
"medline_journal": "Exp Cell Res",
"ISO_journal": "Exp Cell Res",
"authors": [
"Narita T",
"Nishimura T",
"Yoshizaki K",
"Taniyama T."
],
"DOI_URL": null
},
"PUB00048075": {
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"ISBN": null,
"volume": "39",
"issue": "4",
"year": 2007,
"title": "The high resolution NMR structure of the third SH3 domain of CD2AP.",
"URL": null,
"raw_pages": "331-6",
"medline_journal": "J Biomol NMR",
"ISO_journal": "J. Biomol. NMR",
"authors": [
"Ortega Roldan JL",
"Romero Romero ML",
"Ora A",
"Ab E",
"Lopez Mayorga O",
"Azuaga AI",
"van Nuland NA."
],
"DOI_URL": "http://dx.doi.org/10.1007/s10858-007-9201-7"
},
"PUB00048247": {
"PMID": 18680311,
"ISBN": null,
"volume": "47",
"issue": "34",
"year": 2008,
"title": "Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination.",
"URL": null,
"raw_pages": "8937-49",
"medline_journal": "Biochemistry",
"ISO_journal": "Biochemistry",
"authors": [
"Bezsonova I",
"Bruce MC",
"Wiesner S",
"Lin H",
"Rotin D",
"Forman-Kay JD."
],
"DOI_URL": "http://dx.doi.org/10.1021/bi800439t"
},
"PUB00086160": {
"PMID": 19268472,
"ISBN": null,
"volume": "387",
"issue": "5",
"year": 2009,
"title": "Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications.",
"URL": null,
"raw_pages": "1120-36",
"medline_journal": "J Mol Biol",
"ISO_journal": "J. Mol. Biol.",
"authors": [
"Ababou A",
"Pfuhl M",
"Ladbury JE."
],
"DOI_URL": "https://doi.org/10.1016/j.jmb.2009.02.061"
},
"PUB00085558": {
"PMID": 12461825,
"ISBN": null,
"volume": "61",
"issue": null,
"year": 2002,
"title": "How SH3 domains recognize proline.",
"URL": null,
"raw_pages": "211-68",
"medline_journal": "Adv Protein Chem",
"ISO_journal": "Adv. Protein Chem.",
"authors": [
"Musacchio A."
],
"DOI_URL": "https://doi.org/10.1016/S0065-3233(02)61006-X"
},
"PUB00086158": {
"PMID": 20331533,
"ISBN": null,
"volume": "11",
"issue": "6",
"year": 2010,
"title": "Emerging roles of Ruk/CIN85 in vesicle-mediated transport, adhesion, migration and malignancy.",
"URL": null,
"raw_pages": "721-31",
"medline_journal": "Traffic",
"ISO_journal": "Traffic",
"authors": [
"Havrylov S",
"Redowicz MJ",
"Buchman VL."
],
"DOI_URL": "https://doi.org/10.1111/j.1600-0854.2010.01061.x"
},
"PUB00007124": {
"PMID": 11911877,
"ISBN": null,
"volume": "513",
"issue": "1",
"year": 2002,
"title": "WW and SH3 domains, two different scaffolds to recognize proline-rich ligands.",
"URL": null,
"raw_pages": "30-7",
"medline_journal": "FEBS Lett",
"ISO_journal": "FEBS Lett.",
"authors": [
"Macias MJ",
"Wiesner S",
"Sudol M."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0014-5793(01)03290-2"
},
"PUB00127772": {
"PMID": 11067845,
"ISBN": null,
"volume": "276",
"issue": "7",
"year": 2001,
"title": "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction.",
"URL": null,
"raw_pages": "4957-63",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Kirsch KH",
"Georgescu MM",
"Shishido T",
"Langdon WY",
"Birge RB",
"Hanafusa H."
],
"DOI_URL": null
},
"PUB00127777": {
"PMID": 19945749,
"ISBN": null,
"volume": "47",
"issue": "5",
"year": 2010,
"title": "CD2AP is indispensable to multistep cytotoxic process by NK cells.",
"URL": null,
"raw_pages": "1074-82",
"medline_journal": "Mol Immunol",
"ISO_journal": "Mol Immunol",
"authors": [
"Ma Y",
"Yang H",
"Qi J",
"Liu D",
"Xiong P",
"Xu Y",
"Feng W",
"Zheng G",
"Li P",
"Fang M",
"Tan Z",
"Zheng F",
"Gong F."
],
"DOI_URL": null
}
},
"set_info": {
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"name": "SH3"
},
"overlaps_with": null,
"counters": {
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"domain_architectures": 0,
"interactions": 0,
"matches": 613,
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"structural_models": {
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},
"structures": 0,
"taxa": 1081
},
"entry_annotations": {},
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"is_llm": false,
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}
}
