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{
"metadata": {
"accession": "cd11520",
"entry_id": null,
"type": "domain",
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"source_database": "cdd",
"member_databases": null,
"integrated": "IPR042700",
"hierarchy": null,
"name": {
"name": "Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain",
"short": "SLC5sbd_SMCT2"
},
"description": [
{
"text": "<p>SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. Human SMCT2 (hSMCT2) is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, it is expressed in the apical membrane of the proximal convoluted tubule, along the entire length of the tubule (in contrast to the high-affinity monocarboxylate transporter SMCT1, belonging to a different family, which is limited to the S3 segment of the tubule). SMCT2 may initiate lactate absorption in the early parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT2 is expressed exclusively in Muller cells. Nicotine transport by hSMCT2 is inhibited by several non-steroidal anti-inflammatory drugs. This subgroup belongs to the solute carrier 5 (SLC5) transporter family. [[cite:PUB00093172], [cite:PUB00092178], [cite:PUB00126018], [cite:PUB00093171], [cite:PUB00093168], [cite:PUB00092175], [cite:PUB00093173], [cite:PUB00126019]]</p>",
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"PUB00093172": {
"PMID": 15546855,
"ISBN": null,
"volume": "19",
"issue": null,
"year": 2004,
"title": "Surprising versatility of Na+-glucose cotransporters: SLC5.",
"URL": null,
"raw_pages": "370-6",
"medline_journal": "Physiology (Bethesda)",
"ISO_journal": "Physiology (Bethesda)",
"authors": [
"Wright EM",
"Loo DD",
"Hirayama BA",
"Turk E."
],
"DOI_URL": null
},
"PUB00093173": {
"PMID": 20392797,
"ISBN": null,
"volume": "299",
"issue": "1",
"year": 2010,
"title": "Localization of members of MCT monocarboxylate transporter family Slc16 in the kidney and regulation during metabolic acidosis.",
"URL": null,
"raw_pages": "F141-54",
"medline_journal": "Am J Physiol Renal Physiol",
"ISO_journal": "Am. J. Physiol. Renal Physiol.",
"authors": [
"Becker HM",
"Mohebbi N",
"Perna A",
"Ganapathy V",
"Capasso G",
"Wagner CA."
],
"DOI_URL": null
},
"PUB00092178": {
"PMID": 21527736,
"ISBN": null,
"volume": "91",
"issue": "2",
"year": 2011,
"title": "Biology of human sodium glucose transporters.",
"URL": null,
"raw_pages": "733-94",
"medline_journal": "Physiol Rev",
"ISO_journal": "Physiol. Rev.",
"authors": [
"Wright EM",
"Loo DD",
"Hirayama BA."
],
"DOI_URL": "https://doi.org/10.1152/physrev.00055.2009"
},
"PUB00093171": {
"PMID": 17692818,
"ISBN": null,
"volume": "1768",
"issue": "11",
"year": 2007,
"title": "Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney.",
"URL": null,
"raw_pages": "2690-7",
"medline_journal": "Biochim Biophys Acta",
"ISO_journal": "Biochim. Biophys. Acta",
"authors": [
"Gopal E",
"Umapathy NS",
"Martin PM",
"Ananth S",
"Gnana-Prakasam JP",
"Becker H",
"Wagner CA",
"Ganapathy V",
"Prasad PD."
],
"DOI_URL": null
},
"PUB00093168": {
"PMID": 16104846,
"ISBN": null,
"volume": "392",
"issue": "Pt 3",
"year": 2005,
"title": "Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2).",
"URL": null,
"raw_pages": "655-64",
"medline_journal": "Biochem J",
"ISO_journal": "Biochem. J.",
"authors": [
"Srinivas SR",
"Gopal E",
"Zhuang L",
"Itagaki S",
"Martin PM",
"Fei YJ",
"Ganapathy V",
"Prasad PD."
],
"DOI_URL": null
},
"PUB00092175": {
"PMID": 17591909,
"ISBN": null,
"volume": "48",
"issue": "7",
"year": 2007,
"title": "Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina.",
"URL": null,
"raw_pages": "3356-63",
"medline_journal": "Invest Ophthalmol Vis Sci",
"ISO_journal": "Invest. Ophthalmol. Vis. Sci.",
"authors": [
"Martin PM",
"Dun Y",
"Mysona B",
"Ananth S",
"Roon P",
"Smith SB",
"Ganapathy V."
],
"DOI_URL": "https://doi.org/10.1167/iovs.06-0888"
},
"PUB00126018": {
"PMID": 17255103,
"ISBN": null,
"volume": "282",
"issue": "16",
"year": 2007,
"title": "Zebrafish Slc5a12 encodes an electroneutral sodium monocarboxylate transporter (SMCTn). A comparison with the electrogenic SMCT (SMCTe/Slc5a8).",
"URL": null,
"raw_pages": "11996-2009",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Plata C",
"Sussman CR",
"Sindic A",
"Liang JO",
"Mount DB",
"Josephs ZM",
"Chang MH",
"Romero MF."
],
"DOI_URL": null
},
"PUB00126019": {
"PMID": 20834181,
"ISBN": null,
"volume": "31",
"issue": "4",
"year": 2010,
"title": "The cellular expression of SMCT2 and its comparison with other transporters for monocarboxylates in the mouse digestive tract.",
"URL": null,
"raw_pages": "239-49",
"medline_journal": "Biomed Res",
"ISO_journal": "Biomed Res",
"authors": [
"Teramae H",
"Yoshikawa T",
"Inoue R",
"Ushida K",
"Takebe K",
"Nio-Kobayashi J",
"Iwanaga T."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl00456",
"name": "SLC5-6-like_sbd"
},
"overlaps_with": null,
"counters": {
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"matches": 131,
"pathways": 0,
"proteins": 131,
"proteomes": 112,
"sets": 1,
"structural_models": {
"alphafold": 119,
"bfvd": 0
},
"structures": 0,
"taxa": 412
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
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"representative_structure": null
}
}
