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{
"metadata": {
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"source_database": "cdd",
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"name": {
"name": "N-terminal Mad Homology 1 (MH1) domain in SMAD7",
"short": "MH1_SMAD_7"
},
"description": [
{
"text": "<p>The MH1 is a small DNA-binding domain present in SMAD (small mothers against decapentaplegic) family of proteins. It binds to the major groove in an unusual manner via a beta hairpin structure. It negatively regulates the functions of the MH2 domain, the C-terminal domain of SMAD. This MH1 belongs to SMAD7, an inhibitory SMAD (I-SMAD) or antagonistic SMAD, which acts as a negative regulator of signaling mediated by TGF-beta superfamily ligands, by blocking TGF-beta type 1 and activin association with the receptor as well as access to SMAD2. SMAD7 enhances muscle differentiation, playing pivotal roles in embryonic development and adult homoeostasis. Altered expression of SMAD7 is often associated with cancer, tissue fibrosis and inflammatory diseases. [[cite:PUB00127139], [cite:PUB00127140], [cite:PUB00127141], [cite:PUB00127142], [cite:PUB00112170], [cite:PUB00127149], [cite:PUB00127150], [cite:PUB00127136], [cite:PUB00127137], [cite:PUB00127138], [cite:PUB00114352]]</p>",
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"volume": "30",
"issue": "3",
"year": 2004,
"title": "Smads as intracellular mediators of airway inflammation.",
"URL": null,
"raw_pages": "223-50",
"medline_journal": "Exp Lung Res",
"ISO_journal": "Exp Lung Res",
"authors": [
"Groneberg DA",
"Witt H",
"Adcock IM",
"Hansen G",
"Springer J."
],
"DOI_URL": null
},
"PUB00127141": {
"PMID": 18508563,
"ISBN": null,
"volume": "13",
"issue": null,
"year": 2008,
"title": "Smad7 as a therapeutic agent for chronic kidney diseases.",
"URL": null,
"raw_pages": "4984-92",
"medline_journal": "Front Biosci",
"ISO_journal": "Front Biosci",
"authors": [
"Lan HY."
],
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},
"PUB00127140": {
"PMID": 17704440,
"ISBN": null,
"volume": "27",
"issue": "5",
"year": 2007,
"title": "SMAD7: at the interface of TGF-beta and proinflammatory signaling.",
"URL": null,
"raw_pages": "523-5",
"medline_journal": "Perit Dial Int",
"ISO_journal": "Perit Dial Int",
"authors": [
"Fraser D."
],
"DOI_URL": null
},
"PUB00127149": {
"PMID": 21768661,
"ISBN": null,
"volume": "48",
"issue": "2",
"year": 2011,
"title": "A comprehensive examination of Smad4, Smad6 and Smad7 mRNA expression in pancreatic ductal adenocarcinoma.",
"URL": null,
"raw_pages": "170-4",
"medline_journal": "Indian J Cancer",
"ISO_journal": "Indian J Cancer",
"authors": [
"Singh P",
"Wig JD",
"Srinivasan R",
"Radotra BD."
],
"DOI_URL": null
},
"PUB00127139": {
"PMID": 21269274,
"ISBN": null,
"volume": "434",
"issue": "1",
"year": 2011,
"title": "Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling.",
"URL": null,
"raw_pages": "1-10",
"medline_journal": "Biochem J",
"ISO_journal": "Biochem J",
"authors": [
"Yan X",
"Chen YG."
],
"DOI_URL": null
},
"PUB00112170": {
"PMID": 20517689,
"ISBN": null,
"volume": "155",
"issue": null,
"year": 2010,
"title": "Tgf-beta signaling alterations and colon cancer.",
"URL": null,
"raw_pages": "85-103",
"medline_journal": "Cancer Treat Res",
"ISO_journal": "Cancer Treat Res",
"authors": [
"Bellam N",
"Pasche B."
],
"DOI_URL": null
},
"PUB00114352": {
"PMID": 11243801,
"ISBN": null,
"volume": "307",
"issue": "1",
"year": 2001,
"title": "Mh1 domain of Smad is a degraded homing endonuclease.",
"URL": null,
"raw_pages": "31-7",
"medline_journal": "J Mol Biol",
"ISO_journal": "J Mol Biol",
"authors": [
"Grishin NV."
],
"DOI_URL": null
},
"PUB00127136": {
"PMID": 19352540,
"ISBN": null,
"volume": "41",
"issue": "4",
"year": 2009,
"title": "Regulation of TGF-beta signaling by Smad7.",
"URL": null,
"raw_pages": "263-72",
"medline_journal": "Acta Biochim Biophys Sin (Shanghai)",
"ISO_journal": "Acta Biochim Biophys Sin (Shanghai)",
"authors": [
"Yan X",
"Liu Z",
"Chen Y."
],
"DOI_URL": null
},
"PUB00127142": {
"PMID": 19079231,
"ISBN": null,
"volume": "1 Suppl 1",
"issue": null,
"year": 2008,
"title": "TGF-beta1 and Smad7 in the regulation of IBD.",
"URL": null,
"raw_pages": "S50-3",
"medline_journal": "Mucosal Immunol",
"ISO_journal": "Mucosal Immunol",
"authors": [
"Monteleone G",
"Boirivant M",
"Pallone F",
"MacDonald TT."
],
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},
"PUB00127150": {
"PMID": 21054221,
"ISBN": null,
"volume": "82",
"issue": "4",
"year": 2011,
"title": "Smad7 blocks transforming growth factor-β1-induced gingival fibroblast-myofibroblast transition via inhibitory regulation of Smad2 and connective tissue growth factor.",
"URL": null,
"raw_pages": "642-51",
"medline_journal": "J Periodontol",
"ISO_journal": "J Periodontol",
"authors": [
"Sobral LM",
"Montan PF",
"Zecchin KG",
"Martelli-Junior H",
"Vargas PA",
"Graner E",
"Coletta RD."
],
"DOI_URL": null
},
"PUB00127138": {
"PMID": 16950118,
"ISBN": null,
"volume": "11",
"issue": "3",
"year": 2006,
"title": "Smad7: licensed to kill beta-catenin.",
"URL": null,
"raw_pages": "274-6",
"medline_journal": "Dev Cell",
"ISO_journal": "Dev Cell",
"authors": [
"Millar SE."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl00055",
"name": "MH1"
},
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}
