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{
"metadata": {
"accession": "cd10414",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": "IPR035034",
"hierarchy": null,
"name": {
"name": "Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins",
"short": "SH2_Grb14"
},
"description": [
{
"text": "<p>The Grb family binds to the epidermal growth factor receptor (EGFR, erbB1) via their SH2 domains. Grb14 is part of the Grb7 family of proteins which also includes Grb7, and Grb14. They are composed of an N-terminal Proline-rich domain, a Ras Associating-like (RA) domain, a Pleckstrin Homology (PH) domain, a phosphotyrosine interaction region (PIR, BPS) and a C-terminal SH2 domain. The SH2 domains of Grb7, Grb10 and Grb14 preferentially bind to a different RTK. Grb14 binds to Fibroblast Growth Factor Receptor (FGFR) and weakly to the erbB2 receptor. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites. [[cite:PUB00022206], [cite:PUB00124754], [cite:PUB00124755], [cite:PUB00085923], [cite:PUB00085924], [cite:PUB00084837], [cite:PUB00084838]]</p>",
"llm": false,
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}
],
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"literature": {
"PUB00124754": {
"PMID": 11607834,
"ISBN": null,
"volume": "20",
"issue": "44",
"year": 2001,
"title": "The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions.",
"URL": null,
"raw_pages": "6315-21",
"medline_journal": "Oncogene",
"ISO_journal": "Oncogene",
"authors": [
"Han DC",
"Shen TL",
"Guan JL."
],
"DOI_URL": null
},
"PUB00084838": {
"PMID": 19273114,
"ISBN": null,
"volume": "14",
"issue": null,
"year": 2009,
"title": "SH2 domain binding to phosphopeptide ligands: potential for drug targeting.",
"URL": null,
"raw_pages": "1010-22",
"medline_journal": "Front Biosci (Landmark Ed)",
"ISO_journal": "Front Biosci (Landmark Ed)",
"authors": [
"Kasembeli MM",
"Xu X",
"Tweardy DJ."
],
"DOI_URL": "https://doi.org/10.2741/3292"
},
"PUB00124755": {
"PMID": 20980250,
"ISBN": null,
"volume": "285",
"issue": "53",
"year": 2010,
"title": "Structural basis for the interaction between the growth factor-binding protein GRB10 and the E3 ubiquitin ligase NEDD4.",
"URL": null,
"raw_pages": "42130-9",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Huang Q",
"Szebenyi DM."
],
"DOI_URL": null
},
"PUB00085924": {
"PMID": 10398925,
"ISBN": null,
"volume": "19",
"issue": "4",
"year": 1999,
"title": "SH2 domains: from structure to energetics, a dual approach to the study of structure-function relationships.",
"URL": null,
"raw_pages": "273-93",
"medline_journal": "Med Res Rev",
"ISO_journal": "Med Res Rev",
"authors": [
"Grucza RA",
"Bradshaw JM",
"Futterer K",
"Waksman G."
],
"DOI_URL": "https://doi.org/10.1002/(SICI)1098-1128(199907)19:4<273::AID-MED2>3.0.CO;2-G"
},
"PUB00084837": {
"PMID": 19926274,
"ISBN": null,
"volume": "19",
"issue": "6",
"year": 2009,
"title": "SH2 domains: modulators of nonreceptor tyrosine kinase activity.",
"URL": null,
"raw_pages": "643-9",
"medline_journal": "Curr Opin Struct Biol",
"ISO_journal": "Curr. Opin. Struct. Biol.",
"authors": [
"Filippakopoulos P",
"Muller S",
"Knapp S."
],
"DOI_URL": "https://doi.org/10.1016/j.sbi.2009.10.001"
},
"PUB00022206": {
"PMID": 12975581,
"ISBN": null,
"volume": "27",
"issue": "3",
"year": 2003,
"title": "Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2.",
"URL": null,
"raw_pages": "205-19",
"medline_journal": "J Biomol NMR",
"ISO_journal": "J. Biomol. NMR",
"authors": [
"Ivancic M",
"Daly RJ",
"Lyons BA."
],
"DOI_URL": "http://dx.doi.org/10.1023/A:1025498409113"
},
"PUB00085923": {
"PMID": 9241420,
"ISBN": null,
"volume": "26",
"issue": null,
"year": 1997,
"title": "Modular peptide recognition domains in eukaryotic signaling.",
"URL": null,
"raw_pages": "259-88",
"medline_journal": "Annu Rev Biophys Biomol Struct",
"ISO_journal": "Annu Rev Biophys Biomol Struct",
"authors": [
"Kuriyan J",
"Cowburn D."
],
"DOI_URL": "https://doi.org/10.1146/annurev.biophys.26.1.259"
}
},
"set_info": {
"accession": "cl15255",
"name": "SH2"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 665,
"pathways": 0,
"proteins": 665,
"proteomes": 451,
"sets": 1,
"structural_models": {
"alphafold": 606,
"bfvd": 0
},
"structures": 0,
"taxa": 1358
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
