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{
"metadata": {
"accession": "cd07770",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": null,
"hierarchy": null,
"name": {
"name": "nucleotide-binding domain (NBD) of gluconate kinase (GntK) and similar proteins",
"short": "ASKHA_NBD_FGGY_GntK"
},
"description": [
{
"text": "<p>GntK (EC 2.7.1.12), also known as gluconokinase, catalyzes the ATP-dependent phosphorylation of D-gluconate and produce 6-phospho-D-gluconate and ADP. The presence of Mg2+ might be required for catalytic activity. The prototypical member of this subfamily is GntK from Lactobacillus acidophilus. Unlike Escherichia coli GntK, which belongs to the superfamily of P-loop containing nucleoside triphosphate hydrolases, Members of this subfamily are homologous to glycerol kinase, xylulose kinase, and rhamnulokinase from Escherichia coli. They have been classified as members of the FGGY family of carbohydrate kinases, which contain two large domains separated by a deep cleft that forms the active site. This model spans both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. [[cite:PUB00087026], [cite:PUB00087027], [cite:PUB00087028], [cite:PUB00003806], [cite:PUB00087029], [cite:PUB00087030], [cite:PUB00087031]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00087031": {
"PMID": 3011959,
"ISBN": null,
"volume": "132",
"issue": "1",
"year": 1986,
"title": "The characterization and cloning of a gluconate (gnt) operon of Bacillus subtilis.",
"URL": null,
"raw_pages": "161-9",
"medline_journal": "J Gen Microbiol",
"ISO_journal": "J. Gen. Microbiol.",
"authors": [
"Fujita Y",
"Nihashi J",
"Fujita T."
],
"DOI_URL": "https://doi.org/10.1099/00221287-132-1-161"
},
"PUB00087029": {
"PMID": 3036241,
"ISBN": null,
"volume": "924",
"issue": "3",
"year": 1987,
"title": "Gluconate metabolism in germinated spores of Bacillus megaterium QM B1551: primary roles of gluconokinase and the pentose cycle.",
"URL": null,
"raw_pages": "467-72",
"medline_journal": "Biochim Biophys Acta",
"ISO_journal": "Biochim. Biophys. Acta",
"authors": [
"Otani M",
"Fujita T",
"Umezawa C",
"Sano K."
],
"DOI_URL": null
},
"PUB00003806": {
"PMID": 1659648,
"ISBN": null,
"volume": "5",
"issue": "5",
"year": 1991,
"title": "Analysis of the gluconate (gnt) operon of Bacillus subtilis.",
"URL": null,
"raw_pages": "1081-9",
"medline_journal": "Mol Microbiol",
"ISO_journal": "Mol. Microbiol.",
"authors": [
"Reizer A",
"Deutscher J",
"Saier MH Jr",
"Reizer J."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1365-2958.1991.tb01880.x"
},
"PUB00087027": {
"PMID": 10591018,
"ISBN": null,
"volume": "3",
"issue": "4",
"year": 1999,
"title": "Catabolic pathways of glucose in Bacillus circulans var. alkalophilus.",
"URL": null,
"raw_pages": "269-76",
"medline_journal": "Extremophiles",
"ISO_journal": "Extremophiles",
"authors": [
"Paavilainen S",
"Oinonen S",
"Korpela T."
],
"DOI_URL": "https://doi.org/10.1007/s007920050127"
},
"PUB00087030": {
"PMID": 3020045,
"ISBN": null,
"volume": "261",
"issue": "29",
"year": 1986,
"title": "Organization and transcription of the gluconate operon, gnt, of Bacillus subtilis.",
"URL": null,
"raw_pages": "13744-53",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Fujita Y",
"Fujita T",
"Miwa Y",
"Nihashi J",
"Aratani Y."
],
"DOI_URL": null
},
"PUB00087026": {
"PMID": 16385030,
"ISBN": null,
"volume": "188",
"issue": "2",
"year": 2006,
"title": "Characterization and use of catabolite-repressed promoters from gluconate genes in Corynebacterium glutamicum.",
"URL": null,
"raw_pages": "409-23",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"Letek M",
"Valbuena N",
"Ramos A",
"Ordonez E",
"Gil JA",
"Mateos LM."
],
"DOI_URL": "https://doi.org/10.1128/JB.188.2.409-423.2006"
},
"PUB00087028": {
"PMID": 8535972,
"ISBN": null,
"volume": "1",
"issue": "4",
"year": 1994,
"title": "Nucleotide sequence and features of the Bacillus licheniformis gnt operon.",
"URL": null,
"raw_pages": "157-62",
"medline_journal": "DNA Res",
"ISO_journal": "DNA Res.",
"authors": [
"Yoshida K",
"Seki S",
"Fujita Y."
],
"DOI_URL": "https://doi.org/10.1093/dnares/1.4.157"
}
},
"set_info": {
"accession": "cl17037",
"name": "NBD_sugar-kinase_HSP70_actin"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 4467,
"pathways": 0,
"proteins": 4467,
"proteomes": 2631,
"sets": 1,
"structural_models": {
"alphafold": 3384,
"bfvd": 0
},
"structures": 2,
"taxa": 4428
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
