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{
"metadata": {
"accession": "cd07662",
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"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": "IPR028657",
"hierarchy": null,
"name": {
"name": "The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 6",
"short": "BAR_SNX6"
},
"description": [
{
"text": "<p>BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. Sorting nexins (SNXs) are Phox homology (PX) domain containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system. SNXs differ from each other in their lipid-binding specificity, subcellular localization and specific function in the endocytic pathway. A subset of SNXs also contain BAR domains. The PX-BAR structural unit determines the specific membrane targeting of SNXs. SNX6 forms a stable complex with SNX1 and may be a component of the retromer complex, a membrane coat multimeric complex required for endosomal retrieval of lysosomal hydrolase receptors to the Golgi, acting as a mammalian equivalent of yeast Vsp17p. It interacts with the receptor serine/threonine kinases from the transforming growth factor-beta family. It also plays roles in enhancing the degradation of EGFR and in regulating the activity of Na,K-ATPase through its interaction with Translationally Controlled Tumor Protein (TCTP). BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. [[cite:PUB00084391], [cite:PUB00068935], [cite:PUB00010010], [cite:PUB00085948], [cite:PUB00101606], [cite:PUB00101604], [cite:PUB00101605], [cite:PUB00027956], [cite:PUB00027993], [cite:PUB00027894], [cite:PUB00085640], [cite:PUB00085641], [cite:PUB00018467], [cite:PUB00014978], [cite:PUB00068557]]</p>",
"llm": false,
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}
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"literature": {
"PUB00101606": {
"PMID": 18523162,
"ISBN": null,
"volume": "22",
"issue": "10",
"year": 2008,
"title": "An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor.",
"URL": null,
"raw_pages": "3607-16",
"medline_journal": "FASEB J",
"ISO_journal": "FASEB J",
"authors": [
"Cavet ME",
"Pang J",
"Yin G",
"Berk BC."
],
"DOI_URL": null
},
"PUB00014978": {
"PMID": 14993925,
"ISBN": null,
"volume": "5",
"issue": "3",
"year": 2004,
"title": "The BAR-domain family of proteins: a case of bending and binding?",
"URL": null,
"raw_pages": "250-5",
"medline_journal": "EMBO Rep",
"ISO_journal": "EMBO Rep.",
"authors": [
"Habermann B."
],
"DOI_URL": "http://dx.doi.org/10.1038/sj.embor.7400105"
},
"PUB00068935": {
"PMID": 16243015,
"ISBN": null,
"volume": "15",
"issue": "20",
"year": 2005,
"title": "Sorting nexins.",
"URL": null,
"raw_pages": "R819-20",
"medline_journal": "Curr Biol",
"ISO_journal": "Curr. Biol.",
"authors": [
"Carlton JG",
"Cullen PJ."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.cub.2005.10.012"
},
"PUB00027894": {
"PMID": 11591366,
"ISBN": null,
"volume": "506",
"issue": "1",
"year": 2001,
"title": "Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus.",
"URL": null,
"raw_pages": "33-8",
"medline_journal": "FEBS Lett",
"ISO_journal": "FEBS Lett.",
"authors": [
"Ishibashi Y",
"Maita H",
"Yano M",
"Koike N",
"Tamai K",
"Ariga H",
"Iguchi-Ariga SM."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0014-5793(01)02881-2"
},
"PUB00101604": {
"PMID": 17148574,
"ISBN": null,
"volume": "120",
"issue": "Pt 1",
"year": 2007,
"title": "A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer.",
"URL": null,
"raw_pages": "45-54",
"medline_journal": "J Cell Sci",
"ISO_journal": "J Cell Sci",
"authors": [
"Wassmer T",
"Attar N",
"Bujny MV",
"Oakley J",
"Traer CJ",
"Cullen PJ."
],
"DOI_URL": null
},
"PUB00085948": {
"PMID": 18523436,
"ISBN": null,
"volume": "9",
"issue": "7",
"year": 2008,
"title": "Endosomal sorting and signalling: an emerging role for sorting nexins.",
"URL": null,
"raw_pages": "574-82",
"medline_journal": "Nat Rev Mol Cell Biol",
"ISO_journal": "Nat. Rev. Mol. Cell Biol.",
"authors": [
"Cullen PJ."
],
"DOI_URL": "https://doi.org/10.1038/nrm2427"
},
"PUB00085640": {
"PMID": 15649145,
"ISBN": null,
"volume": null,
"issue": "72",
"year": 2005,
"title": "BAR domains and membrane curvature: bringing your curves to the BAR.",
"URL": null,
"raw_pages": "223-31",
"medline_journal": "Biochem Soc Symp",
"ISO_journal": "Biochem. Soc. Symp.",
"authors": [
"Gallop JL",
"McMahon HT."
],
"DOI_URL": null
},
"PUB00068557": {
"PMID": 19379681,
"ISBN": null,
"volume": "137",
"issue": "2",
"year": 2009,
"title": "The BAR domain superfamily: membrane-molding macromolecules.",
"URL": null,
"raw_pages": "191-6",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Frost A",
"Unger VM",
"De Camilli P."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.cell.2009.04.010"
},
"PUB00101605": {
"PMID": 16730713,
"ISBN": null,
"volume": "580",
"issue": "14",
"year": 2006,
"title": "Inhibition of Na,K-ATPase-suppressive activity of translationally controlled tumor protein by sorting nexin 6.",
"URL": null,
"raw_pages": "3558-64",
"medline_journal": "FEBS Lett",
"ISO_journal": "FEBS Lett",
"authors": [
"Yoon T",
"Kim M",
"Lee K."
],
"DOI_URL": null
},
"PUB00027993": {
"PMID": 11279102,
"ISBN": null,
"volume": "276",
"issue": "22",
"year": 2001,
"title": "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases.",
"URL": null,
"raw_pages": "19332-9",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Parks WT",
"Frank DB",
"Huff C",
"Renfrew Haft C",
"Martin J",
"Meng X",
"de Caestecker MP",
"McNally JG",
"Reddi A",
"Taylor SI",
"Roberts AB",
"Wang T",
"Lechleider RJ."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M100606200"
},
"PUB00018467": {
"PMID": 15043839,
"ISBN": null,
"volume": "14",
"issue": "6",
"year": 2004,
"title": "Membrane curvature: how BAR domains bend bilayers.",
"URL": null,
"raw_pages": "R250-2",
"medline_journal": "Curr Biol",
"ISO_journal": "Curr. Biol.",
"authors": [
"Zimmerberg J",
"McLaughlin S."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.cub.2004.02.060"
},
"PUB00010010": {
"PMID": 12461558,
"ISBN": null,
"volume": "3",
"issue": "12",
"year": 2002,
"title": "Sorting out the cellular functions of sorting nexins.",
"URL": null,
"raw_pages": "919-31",
"medline_journal": "Nat Rev Mol Cell Biol",
"ISO_journal": "Nat. Rev. Mol. Cell Biol.",
"authors": [
"Worby CA",
"Dixon JE."
],
"DOI_URL": "http://dx.doi.org/10.1038/nrm974"
},
"PUB00084391": {
"PMID": 15634208,
"ISBN": null,
"volume": "6",
"issue": "2",
"year": 2005,
"title": "Sorting nexins--unifying trends and new perspectives.",
"URL": null,
"raw_pages": "75-82",
"medline_journal": "Traffic",
"ISO_journal": "Traffic",
"authors": [
"Carlton J",
"Bujny M",
"Rutherford A",
"Cullen P."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1600-0854.2005.00260.x"
},
"PUB00027956": {
"PMID": 11485546,
"ISBN": null,
"volume": "358",
"issue": "Pt 1",
"year": 2001,
"title": "A large family of endosome-localized proteins related to sorting nexin 1.",
"URL": null,
"raw_pages": "7-16",
"medline_journal": "Biochem J",
"ISO_journal": "Biochem. J.",
"authors": [
"Teasdale RD",
"Loci D",
"Houghton F",
"Karlsson L",
"Gleeson PA."
],
"DOI_URL": "http://dx.doi.org/10.1042/0264-6021:3580007"
},
"PUB00085641": {
"PMID": 16524918,
"ISBN": null,
"volume": "70",
"issue": "1",
"year": 2006,
"title": "The BAR domain proteins: molding membranes in fission, fusion, and phagy.",
"URL": null,
"raw_pages": "37-120",
"medline_journal": "Microbiol Mol Biol Rev",
"ISO_journal": "Microbiol. Mol. Biol. Rev.",
"authors": [
"Ren G",
"Vajjhala P",
"Lee JS",
"Winsor B",
"Munn AL."
],
"DOI_URL": "https://doi.org/10.1128/MMBR.70.1.37-120.2006"
}
},
"set_info": {
"accession": "cl12013",
"name": "BAR"
},
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"counters": {
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"matches": 252,
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},
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},
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"is_llm": false,
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}
}
