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{
"metadata": {
"accession": "cd05912",
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"type": "domain",
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"source_database": "cdd",
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"name": {
"name": "O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE)",
"short": "OSB_CoA_lg"
},
"description": [
{
"text": "<p>O-succinylbenzoic acid-CoA synthase catalyzes the coenzyme A (CoA)- and ATP-dependent conversion of o-succinylbenzoic acid to o-succinylbenzoyl-CoA. The reaction is the fourth step of the biosynthesis pathway of menaquinone (vitamin K2). In certain bacteria, menaquinone is used during fumarate reduction in anaerobic respiration. In cyanobacteria, the product of the menaquinone pathway is phylloquinone (2-methyl-3-phytyl-1,4-naphthoquinone), a molecule used exclusively as an electron transfer cofactor in Photosystem 1. In green sulfur bacteria and heliobacteria, menaquinones are used as loosely bound secondary electron acceptors in the photosynthetic reaction center. [[cite:PUB00081791], [cite:PUB00014943], [cite:PUB00119903], [cite:PUB00119904], [cite:PUB00119905], [cite:PUB00086767], [cite:PUB00086768], [cite:PUB00086769]]</p>",
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"literature": {
"PUB00081791": {
"PMID": 9387221,
"ISBN": null,
"volume": "143 ( Pt 11)",
"issue": null,
"year": 1997,
"title": "Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region.",
"URL": null,
"raw_pages": "3431-41",
"medline_journal": "Microbiology",
"ISO_journal": "Microbiology (Reading, Engl.)",
"authors": [
"Lapidus A",
"Galleron N",
"Sorokin A",
"Ehrlich SD."
],
"DOI_URL": "http://dx.doi.org/10.1099/00221287-143-11-3431"
},
"PUB00119904": {
"PMID": 8626063,
"ISBN": null,
"volume": "168",
"issue": "1",
"year": 1996,
"title": "Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menE gene from Escherichia coli.",
"URL": null,
"raw_pages": "43-8",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Sharma V",
"Hudspeth ME",
"Meganathan R."
],
"DOI_URL": null
},
"PUB00086767": {
"PMID": 9373621,
"ISBN": null,
"volume": "36",
"issue": "1",
"year": 1997,
"title": "Fatty acid activation.",
"URL": null,
"raw_pages": "55-83",
"medline_journal": "Prog Lipid Res",
"ISO_journal": "Prog. Lipid Res.",
"authors": [
"Watkins PA."
],
"DOI_URL": "https://doi.org/10.1016/S0163-7827(97)00004-0"
},
"PUB00086768": {
"PMID": 17762044,
"ISBN": null,
"volume": "48",
"issue": "12",
"year": 2007,
"title": "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome.",
"URL": null,
"raw_pages": "2736-50",
"medline_journal": "J Lipid Res",
"ISO_journal": "J. Lipid Res.",
"authors": [
"Watkins PA",
"Maiguel D",
"Jia Z",
"Pevsner J."
],
"DOI_URL": "https://doi.org/10.1194/jlr.M700378-JLR200"
},
"PUB00119905": {
"PMID": 1663748,
"ISBN": null,
"volume": "46",
"issue": "7-8",
"year": 1991,
"title": "o-Succinylbenzoate: coenzyme A ligase, an enzyme involved in menaquinone (vitamin K2) biosynthesis, displays broad specificity.",
"URL": null,
"raw_pages": "585-90",
"medline_journal": "Z Naturforsch C J Biosci",
"ISO_journal": "Z Naturforsch C J Biosci",
"authors": [
"Sieweke HJ",
"Leistner E."
],
"DOI_URL": null
},
"PUB00014943": {
"PMID": 12615349,
"ISBN": null,
"volume": "1557",
"issue": "1-3",
"year": 2003,
"title": "The menD and menE homologs code for 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylate synthase and O-succinylbenzoic acid-CoA synthase in the phylloquinone biosynthetic pathway of Synechocystis sp. PCC 6803.",
"URL": null,
"raw_pages": "67-76",
"medline_journal": "Biochim Biophys Acta",
"ISO_journal": "Biochim. Biophys. Acta",
"authors": [
"Wade Johnson T",
"Naithani S",
"Stewart C Jr",
"Zybailov B",
"Daniel Jones A",
"Golbeck JH",
"Chitnis PR."
],
"DOI_URL": null
},
"PUB00086769": {
"PMID": 11255012,
"ISBN": null,
"volume": "265",
"issue": "1-2",
"year": 2001,
"title": "Molecular evolution of the AMP-forming Acetyl-CoA synthetase.",
"URL": null,
"raw_pages": "95-101",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Karan D",
"David JR",
"Capy P."
],
"DOI_URL": "https://doi.org/10.1016/S0378-1119(01)00358-4"
},
"PUB00119903": {
"PMID": 8955296,
"ISBN": null,
"volume": "178",
"issue": "23",
"year": 1996,
"title": "Menaquinone (vitamin K2) biosynthesis: overexpression, purification, and properties of o-succinylbenzoyl-coenzyme A synthetase from Escherichia coli.",
"URL": null,
"raw_pages": "6778-81",
"medline_journal": "J Bacteriol",
"ISO_journal": "J Bacteriol",
"authors": [
"Kwon O",
"Bhattacharyya DK",
"Meganathan R."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl17068",
"name": "AFD_class_I"
},
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"counters": {
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"interactions": 0,
"matches": 810,
"pathways": 0,
"proteins": 810,
"proteomes": 364,
"sets": 1,
"structural_models": {
"alphafold": 662,
"bfvd": 0
},
"structures": 7,
"taxa": 641
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
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"representative_structure": {
"accession": "5x8f",
"name": "Ternary complex structure of a double mutant I454RA456K of o-Succinylbenzoate CoA Synthetase (MenE) from Bacillus Subtilis bound with AMP and its product analogue OSB-NCoA at 1.76 angstrom"
}
}
}
