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{
"metadata": {
"accession": "cd04086",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": null,
"hierarchy": null,
"name": {
"name": "Carbohydrate Binding Module 35 (CBM35); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains",
"short": "CBM35_mannanase-like"
},
"description": [
{
"text": "<p>This family includes carbohydrate binding module 35 (CBM35) domains that are appended to several carbohydrate binding enzymes, including periplasmic component of ABC-type sugar transport system involved in carbohydrate transport and metabolism, and several glycoside hydrolase (GH) domains, including GH26. These CBM6s are non-catalytic carbohydrate binding domains that facilitate the strong binding of the GH catalytic modules with their dedicated, insoluble substrates. Examples of proteins having CMB35s belonging to this family are mannanase A from Clostridium thermocellum (GH26), Man26B from Paenibacillus sp. BME-14 (GH26), and the multifunctional Cel44C-Man26A from Paenibacillus polymyxa GS01 (which has two GH domains, GH44 and GH26). GH26 mainly includes mannan endo-1,4-beta-mannosidase which hydrolyzes 1,4-beta-D-linkages in mannans, galacto-mannans, glucomannans, and galactoglucomannans, but displays little activity towards other plant cell wall polysaccharides. A few proteins belonging to this family have additional CBM3 domains; these CBM3s are not found in the CBM6-CBM35-CBM36_like superfamily. [[cite:PUB00032219], [cite:PUB00031940], [cite:PUB00033743], [cite:PUB00022324], [cite:PUB00116801], [cite:PUB00116802], [cite:PUB00077754], [cite:PUB00116803], [cite:PUB00081304], [cite:PUB00046329], [cite:PUB00059739]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00116803": {
"PMID": 16912849,
"ISBN": null,
"volume": "73",
"issue": "3",
"year": 2006,
"title": "A cel44C-man26A gene of endophytic Paenibacillus polymyxa GS01 has multi-glycosyl hydrolases in two catalytic domains.",
"URL": null,
"raw_pages": "618-30",
"medline_journal": "Appl Microbiol Biotechnol",
"ISO_journal": "Appl Microbiol Biotechnol",
"authors": [
"Cho KM",
"Hong SY",
"Lee SM",
"Kim YH",
"Kahng GG",
"Kim H",
"Yun HD."
],
"DOI_URL": null
},
"PUB00059739": {
"PMID": 20496884,
"ISBN": null,
"volume": "49",
"issue": "29",
"year": 2010,
"title": "Signature active site architectures illuminate the molecular basis for ligand specificity in family 35 carbohydrate binding module.",
"URL": null,
"raw_pages": "6193-205",
"medline_journal": "Biochemistry",
"ISO_journal": "Biochemistry",
"authors": [
"Correia MA",
"Abbott DW",
"Gloster TM",
"Fernandes VO",
"Prates JA",
"Montanier C",
"Dumon C",
"Williamson MP",
"Tunnicliffe RB",
"Liu Z",
"Flint JE",
"Davies GJ",
"Henrissat B",
"Coutinho PM",
"Fontes CM",
"Gilbert HJ."
],
"DOI_URL": "http://dx.doi.org/10.1021/bi1006139"
},
"PUB00081304": {
"PMID": 19788273,
"ISBN": null,
"volume": "48",
"issue": "43",
"year": 2009,
"title": "Analysis of the structural and functional diversity of plant cell wall specific family 6 carbohydrate binding modules.",
"URL": null,
"raw_pages": "10395-404",
"medline_journal": "Biochemistry",
"ISO_journal": "Biochemistry",
"authors": [
"Abbott DW",
"Ficko-Blean E",
"van Bueren AL",
"Rogowski A",
"Cartmell A",
"Coutinho PM",
"Henrissat B",
"Gilbert HJ",
"Boraston AB."
],
"DOI_URL": "http://dx.doi.org/10.1021/bi9013424"
},
"PUB00116802": {
"PMID": 10589717,
"ISBN": null,
"volume": "145 ( Pt 11)",
"issue": null,
"year": 1999,
"title": "A family 26 mannanase produced by Clostridium thermocellum as a component of the cellulosome contains a domain which is conserved in mannanases from anaerobic fungi.",
"URL": null,
"raw_pages": "3101-3108",
"medline_journal": "Microbiology (Reading)",
"ISO_journal": "Microbiology (Reading)",
"authors": [
"Halstead JR",
"Vercoe PE",
"Gilbert HJ",
"Davidson K",
"Hazlewood GP."
],
"DOI_URL": null
},
"PUB00033743": {
"PMID": 15004011,
"ISBN": null,
"volume": "279",
"issue": "20",
"year": 2004,
"title": "The family 6 carbohydrate binding module CmCBM6-2 contains two ligand-binding sites with distinct specificities.",
"URL": null,
"raw_pages": "21552-9",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Henshaw JL",
"Bolam DN",
"Pires VM",
"Czjzek M",
"Henrissat B",
"Ferreira LM",
"Fontes CM",
"Gilbert HJ."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M401620200"
},
"PUB00022324": {
"PMID": 12634060,
"ISBN": null,
"volume": "327",
"issue": "3",
"year": 2003,
"title": "Structure and ligand binding of carbohydrate-binding module CsCBM6-3 reveals similarities with fucose-specific lectins and \"galactose-binding\" domains.",
"URL": null,
"raw_pages": "659-69",
"medline_journal": "J Mol Biol",
"ISO_journal": "J. Mol. Biol.",
"authors": [
"Boraston AB",
"Notenboom V",
"Warren RA",
"Kilburn DG",
"Rose DR",
"Davies G."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0022-2836(03)00152-9"
},
"PUB00031940": {
"PMID": 15010454,
"ISBN": null,
"volume": "279",
"issue": "20",
"year": 2004,
"title": "The crystal structure of the family 6 carbohydrate binding module from Cellvibrio mixtus endoglucanase 5a in complex with oligosaccharides reveals two distinct binding sites with different ligand specificities.",
"URL": null,
"raw_pages": "21560-8",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Pires VM",
"Henshaw JL",
"Prates JA",
"Bolam DN",
"Ferreira LM",
"Fontes CM",
"Henrissat B",
"Planas A",
"Gilbert HJ",
"Czjzek M."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M401599200"
},
"PUB00077754": {
"PMID": 20372022,
"ISBN": null,
"volume": "20",
"issue": "3",
"year": 2010,
"title": "Cloning and characterization of a novel mannanase from Paenibacillus sp. BME-14.",
"URL": null,
"raw_pages": "518-24",
"medline_journal": "J Microbiol Biotechnol",
"ISO_journal": "J. Microbiol. Biotechnol.",
"authors": [
"Fu X",
"Huang X",
"Liu P",
"Lin L",
"Wu G",
"Li C",
"Feng C",
"Hong Y."
],
"DOI_URL": null
},
"PUB00116801": {
"PMID": 8768520,
"ISBN": null,
"volume": "141",
"issue": "2-3",
"year": 1996,
"title": "Evidence that the Piromyces gene family encoding endo-1,4-mannanases arose through gene duplication.",
"URL": null,
"raw_pages": "183-8",
"medline_journal": "FEMS Microbiol Lett",
"ISO_journal": "FEMS Microbiol Lett",
"authors": [
"Millward-Sadler SJ",
"Hall J",
"Black GW",
"Hazlewood GP",
"Gilbert HJ."
],
"DOI_URL": null
},
"PUB00046329": {
"PMID": 10432306,
"ISBN": null,
"volume": "342 ( Pt 1)",
"issue": null,
"year": 1999,
"title": "Homologous xylanases from Clostridium thermocellum: evidence for bi-functional activity, synergism between xylanase catalytic modules and the presence of xylan-binding domains in enzyme complexes.",
"URL": null,
"raw_pages": "105-10",
"medline_journal": "Biochem J",
"ISO_journal": "Biochem. J.",
"authors": [
"Fernandes AC",
"Fontes CM",
"Gilbert HJ",
"Hazlewood GP",
"Fernandes TH",
"Ferreira LM."
],
"DOI_URL": "http://dx.doi.org/10.1042/0264-6021:3420105"
},
"PUB00032219": {
"PMID": 15501830,
"ISBN": null,
"volume": "280",
"issue": "1",
"year": 2005,
"title": "Family 6 carbohydrate binding modules recognize the non-reducing end of beta-1,3-linked glucans by presenting a unique ligand binding surface.",
"URL": null,
"raw_pages": "530-7",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"van Bueren AL",
"Morland C",
"Gilbert HJ",
"Boraston AB."
],
"DOI_URL": "http://intl.jbc.org/cgi/reprint/280/1/530.pdf"
}
},
"set_info": {
"accession": "cl14880",
"name": "CBM6-CBM35-CBM36_like"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 651,
"pathways": 0,
"proteins": 616,
"proteomes": 444,
"sets": 1,
"structural_models": {
"alphafold": 479,
"bfvd": 0
},
"structures": 1,
"taxa": 977
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
