HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept
{
"metadata": {
"accession": "cd03590",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": "IPR033989",
"hierarchy": null,
"name": {
"name": "C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)",
"short": "CLECT_DC-SIGN_like"
},
"description": [
{
"text": "<p>CLECT_DC-SIGN_like: C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR). This group also contains proteins similar to hepatic asialoglycoprotein receptor (ASGP-R) and langerin in human. These proteins are type II membrane proteins with a CTLD ectodomain. CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. DC-SIGN is thought to mediate the initial contact between dendritic cells and resting T cells, and may also mediate the rolling of DCs on epithelium. DC-SIGN and DC-SIGNR bind to oligosaccharides present on human tissues, as well as, on pathogens including parasites, bacteria, and viruses. DC-SIGN and DC-SIGNR bind to HIV enhancing viral infection of T cells. DC-SIGN and DC-SIGNR are homotetrameric, and contain four CTLDs stabilized by a coiled coil of alpha helices. The hepatic ASGP-R is an endocytic recycling receptor which binds and internalizes desialylated glycoproteins having a terminal galactose or N-acetylgalactosamine residues on their N-linked carbohydrate chains, via the clathrin-coated pit mediated endocytic pathway, and delivers them to lysosomes for degradation. It has been proposed that glycoproteins bearing terminal Sia (sialic acid) alpha2, 6GalNAc and Sia alpha2, 6Gal are endogenous ligands for ASGP-R and that ASGP-R participates in regulating the relative concentration of serum glycoproteins bearing alpha 2,6-linked Sia. The human ASGP-R is a hetero-oligomer composed of two subunits, both of which are found within this group. Langerin is expressed in a subset of dendritic leukocytes, the Langerhans cells (LC). Langerin induces the formation of Birbeck Granules (BGs) and associates with these BGs following internalization. Langerin binds, in a calcium-dependent manner, to glyco-conjugates containing mannose and related sugars mediating their uptake and degradation. Langerin molecules oligomerize as trimers with three CTLDs held together by a coiled-coil of alpha helices. [[cite:PUB00081328], [cite:PUB00081329], [cite:PUB00081330], [cite:PUB00002490], [cite:PUB00081331], [cite:PUB00081332], [cite:PUB00081333], [cite:PUB00032369], [cite:PUB00031102], [cite:PUB00081976], [cite:PUB00081977], [cite:PUB00081978], [cite:PUB00081979], [cite:PUB00081334], [cite:PUB00081335]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00081976": {
"PMID": 14610287,
"ISBN": null,
"volume": "28",
"issue": "2",
"year": 2003,
"title": "Langerin/CD207 sheds light on formation of birbeck granules and their possible function in Langerhans cells.",
"URL": null,
"raw_pages": "93-107",
"medline_journal": "Immunol Res",
"ISO_journal": "Immunol. Res.",
"authors": [
"Valladeau J",
"Dezutter-Dambuyant C",
"Saeland S."
],
"DOI_URL": "http://dx.doi.org/10.1385/IR:28:2:93"
},
"PUB00081330": {
"PMID": 8155265,
"ISBN": null,
"volume": "15",
"issue": "2",
"year": 1994,
"title": "Collectins: collagenous C-type lectins of the innate immune defense system.",
"URL": null,
"raw_pages": "67-74",
"medline_journal": "Immunol Today",
"ISO_journal": "Immunol. Today",
"authors": [
"Holmskov U",
"Malhotra R",
"Sim RB",
"Jensenius JC."
],
"DOI_URL": "http://dx.doi.org/10.1016/0167-5699(94)90136-8"
},
"PUB00081334": {
"PMID": 12866057,
"ISBN": null,
"volume": "52",
"issue": "3",
"year": 2003,
"title": "Comparative analysis of structural properties of the C-type-lectin-like domain (CTLD).",
"URL": null,
"raw_pages": "466-77",
"medline_journal": "Proteins",
"ISO_journal": "Proteins",
"authors": [
"Zelensky AN",
"Gready JE."
],
"DOI_URL": "http://dx.doi.org/10.1002/prot.10626"
},
"PUB00032369": {
"PMID": 15509576,
"ISBN": null,
"volume": "280",
"issue": "2",
"year": 2005,
"title": "Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR.",
"URL": null,
"raw_pages": "1327-35",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Feinberg H",
"Guo Y",
"Mitchell DA",
"Drickamer K",
"Weis WI."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M409925200"
},
"PUB00081331": {
"PMID": 11425795,
"ISBN": null,
"volume": "11",
"issue": "5",
"year": 2001,
"title": "Lectin-like proteins in model organisms: implications for evolution of carbohydrate-binding activity.",
"URL": null,
"raw_pages": "71R-9R",
"medline_journal": "Glycobiology",
"ISO_journal": "Glycobiology",
"authors": [
"Dodd RB",
"Drickamer K."
],
"DOI_URL": "http://dx.doi.org/10.1093/glycob/11.5.71R"
},
"PUB00081332": {
"PMID": 9700499,
"ISBN": null,
"volume": "163",
"issue": null,
"year": 1998,
"title": "The C-type lectin superfamily in the immune system.",
"URL": null,
"raw_pages": "19-34",
"medline_journal": "Immunol Rev",
"ISO_journal": "Immunol. Rev.",
"authors": [
"Weis WI",
"Taylor ME",
"Drickamer K."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1600-065X.1998.tb01185.x"
},
"PUB00081977": {
"PMID": 15601833,
"ISBN": null,
"volume": "25",
"issue": "1",
"year": 2005,
"title": "Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function.",
"URL": null,
"raw_pages": "88-99",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Kissenpfennig A",
"Ait-Yahia S",
"Clair-Moninot V",
"Stossel H",
"Badell E",
"Bordat Y",
"Pooley JL",
"Lang T",
"Prina E",
"Coste I",
"Gresser O",
"Renno T",
"Winter N",
"Milon G",
"Shortman K",
"Romani N",
"Lebecque S",
"Malissen B",
"Saeland S",
"Douillard P."
],
"DOI_URL": "http://dx.doi.org/10.1128/MCB.25.1.88-99.2005"
},
"PUB00081329": {
"PMID": 8811186,
"ISBN": null,
"volume": "65",
"issue": null,
"year": 1996,
"title": "Structural basis of lectin-carbohydrate recognition.",
"URL": null,
"raw_pages": "441-73",
"medline_journal": "Annu Rev Biochem",
"ISO_journal": "Annu. Rev. Biochem.",
"authors": [
"Weis WI",
"Drickamer K."
],
"DOI_URL": "http://dx.doi.org/10.1146/annurev.bi.65.070196.002301"
},
"PUB00081979": {
"PMID": 11337487,
"ISBN": null,
"volume": "276",
"issue": "35",
"year": 2001,
"title": "Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts.",
"URL": null,
"raw_pages": "33196-212",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Mummidi S",
"Catano G",
"Lam L",
"Hoefle A",
"Telles V",
"Begum K",
"Jimenez F",
"Ahuja SS",
"Ahuja SK."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M009807200"
},
"PUB00081333": {
"PMID": 10508765,
"ISBN": null,
"volume": "9",
"issue": "5",
"year": 1999,
"title": "C-type lectin-like domains.",
"URL": null,
"raw_pages": "585-90",
"medline_journal": "Curr Opin Struct Biol",
"ISO_journal": "Curr. Opin. Struct. Biol.",
"authors": [
"Drickamer K."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0959-440X(99)00009-3"
},
"PUB00081335": {
"PMID": 16336259,
"ISBN": null,
"volume": "272",
"issue": "24",
"year": 2005,
"title": "The C-type lectin-like domain superfamily.",
"URL": null,
"raw_pages": "6179-217",
"medline_journal": "FEBS J",
"ISO_journal": "FEBS J.",
"authors": [
"Zelensky AN",
"Gready JE."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1742-4658.2005.05031.x"
},
"PUB00002490": {
"PMID": 3290208,
"ISBN": null,
"volume": "263",
"issue": "20",
"year": 1988,
"title": "Two distinct classes of carbohydrate-recognition domains in animal lectins.",
"URL": null,
"raw_pages": "9557-60",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Drickamer K."
],
"DOI_URL": "http://intl.jbc.org/cgi/reprint/263/20/9557.pdf"
},
"PUB00081328": {
"PMID": 9433125,
"ISBN": null,
"volume": "22",
"issue": "12",
"year": 1997,
"title": "Lectin-carbohydrate interactions: different folds, common recognition principles.",
"URL": null,
"raw_pages": "462-7",
"medline_journal": "Trends Biochem Sci",
"ISO_journal": "Trends Biochem. Sci.",
"authors": [
"Elgavish S",
"Shaanan B."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0968-0004(97)01146-8"
},
"PUB00031102": {
"PMID": 15195147,
"ISBN": null,
"volume": "11",
"issue": "7",
"year": 2004,
"title": "Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR.",
"URL": null,
"raw_pages": "591-8",
"medline_journal": "Nat Struct Mol Biol",
"ISO_journal": "Nat. Struct. Mol. Biol.",
"authors": [
"Guo Y",
"Feinberg H",
"Conroy E",
"Mitchell DA",
"Alvarez R",
"Blixt O",
"Taylor ME",
"Weis WI",
"Drickamer K."
],
"DOI_URL": "http://dx.doi.org/10.1038/nsmb784"
},
"PUB00081978": {
"PMID": 12171918,
"ISBN": null,
"volume": "277",
"issue": "43",
"year": 2002,
"title": "Nonpalmitoylated human asialoglycoprotein receptors recycle constitutively but are defective in coated pit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes.",
"URL": null,
"raw_pages": "40844-52",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Yik JH",
"Saxena A",
"Weigel JA",
"Weigel PH."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M204780200"
}
},
"set_info": {
"accession": "cl02432",
"name": "CLECT"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 13536,
"pathways": 0,
"proteins": 13367,
"proteomes": 774,
"sets": 1,
"structural_models": {
"alphafold": 11359,
"bfvd": 0
},
"structures": 98,
"taxa": 2559
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "6puv",
"name": "Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin"
}
}
}
