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{
"metadata": {
"accession": "cd02932",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": "IPR044152",
"hierarchy": null,
"name": {
"name": null,
"short": "OYE_YqiM_FMN"
},
"description": [
{
"text": "<p>Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing agent. The YqjM enzyme exists as a homotetramer that is assembled as a dimer of catalytically dependent dimers, while other OYE members exist only as monomers or dimers. Moreover, the protein displays a shared active site architecture where an arginine finger at the COOH terminus of one monomer extends into the active site of the adjacent monomer and is directly involved in substrate recognition. Another remarkable difference in the binding of the ligand in YqjM is represented by the contribution of the NH2-terminal tyrosine instead of a COOH-terminal tyrosine in OYE and its homologs. [[cite:PUB00116023], [cite:PUB00116469], [cite:PUB00041324]]</p>",
"llm": false,
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"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00041324": {
"PMID": 16822524,
"ISBN": null,
"volume": "361",
"issue": "1",
"year": 2006,
"title": "Xenobiotic reductase A in the degradation of quinoline by Pseudomonas putida 86: physiological function, structure and mechanism of 8-hydroxycoumarin reduction.",
"URL": null,
"raw_pages": "140-52",
"medline_journal": "J Mol Biol",
"ISO_journal": "J. Mol. Biol.",
"authors": [
"Griese JJ",
"P Jakob R",
"Schwarzinger S",
"Dobbek H."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.jmb.2006.06.007"
},
"PUB00116469": {
"PMID": 8529830,
"ISBN": null,
"volume": "9",
"issue": "15",
"year": 1995,
"title": "Flavoprotein structure and mechanism. 8. Structure-function relations for old yellow enzyme.",
"URL": null,
"raw_pages": "1518-26",
"medline_journal": "FASEB J",
"ISO_journal": "FASEB J",
"authors": [
"Karplus PA",
"Fox KM",
"Massey V."
],
"DOI_URL": null
},
"PUB00116023": {
"PMID": 12055282,
"ISBN": null,
"volume": "148",
"issue": "Pt 6",
"year": 2002,
"title": "'New uses for an Old Enzyme'--the Old Yellow Enzyme family of flavoenzymes.",
"URL": null,
"raw_pages": "1607-1614",
"medline_journal": "Microbiology (Reading)",
"ISO_journal": "Microbiology (Reading)",
"authors": [
"Williams RE",
"Bruce NC."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl21457",
"name": "TIM"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 19753,
"pathways": 0,
"proteins": 19750,
"proteomes": 9996,
"sets": 1,
"structural_models": {
"alphafold": 14693,
"bfvd": 0
},
"structures": 54,
"taxa": 15746
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "3hgj",
"name": "Old Yellow Enzyme from Thermus scotoductus SA-01 complexed with p-hydroxy-benzaldehyde"
}
}
}
