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{
"metadata": {
"accession": "cd00170",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": "IPR001251",
"hierarchy": null,
"name": {
"name": "Sec14p-like lipid-binding domain",
"short": "SEC14"
},
"description": [
{
"text": "<p>Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits. [[cite:PUB00018189], [cite:PUB00113494], [cite:PUB00113495], [cite:PUB00004273], [cite:PUB00113496], [cite:PUB00068738], [cite:PUB00113497], [cite:PUB00113498], [cite:PUB00113499], [cite:PUB00113500]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00068738": {
"PMID": 9139723,
"ISBN": null,
"volume": "272",
"issue": "19",
"year": 1997,
"title": "Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptidylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme.",
"URL": null,
"raw_pages": "12667-75",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Alam MR",
"Johnson RC",
"Darlington DN",
"Hand TA",
"Mains RE",
"Eipper BA."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.272.19.12667"
},
"PUB00018189": {
"PMID": 10209105,
"ISBN": null,
"volume": "9",
"issue": "6",
"year": 1999,
"title": "Sec14p-like domains in NF1 and Dbl-like proteins indicate lipid regulation of Ras and Rho signaling.",
"URL": null,
"raw_pages": "R195-7",
"medline_journal": "Curr Biol",
"ISO_journal": "Curr. Biol.",
"authors": [
"Aravind L",
"Neuwald AF",
"Ponting CP."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0960-9822(99)80127-4"
},
"PUB00113498": {
"PMID": 1557404,
"ISBN": null,
"volume": "89",
"issue": "7",
"year": 1992,
"title": "Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p.",
"URL": null,
"raw_pages": "2980-4",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc Natl Acad Sci U S A",
"authors": [
"Gu M",
"Warshawsky I",
"Majerus PW."
],
"DOI_URL": null
},
"PUB00004273": {
"PMID": 9461221,
"ISBN": null,
"volume": "391",
"issue": "6666",
"year": 1998,
"title": "Crystal structure of the Saccharomyces cerevisiae phosphatidylinositol-transfer protein.",
"URL": null,
"raw_pages": "506-10",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Sha B",
"Phillips SE",
"Bankaitis VA",
"Luo M."
],
"DOI_URL": "http://dx.doi.org/10.1038/35179"
},
"PUB00113495": {
"PMID": 10570254,
"ISBN": null,
"volume": "1441",
"issue": "2-3",
"year": 1999,
"title": "PI transfer protein: the specific recognition of phospholipids and its functions.",
"URL": null,
"raw_pages": "268-77",
"medline_journal": "Biochim Biophys Acta",
"ISO_journal": "Biochim Biophys Acta",
"authors": [
"Sha B",
"Luo M."
],
"DOI_URL": null
},
"PUB00113494": {
"PMID": 10518015,
"ISBN": null,
"volume": "459",
"issue": "2",
"year": 1999,
"title": "Association of the proto-oncogene product dbl with G protein betagamma subunits.",
"URL": null,
"raw_pages": "186-90",
"medline_journal": "FEBS Lett",
"ISO_journal": "FEBS Lett",
"authors": [
"Nishida K",
"Kaziro Y",
"Satoh T."
],
"DOI_URL": null
},
"PUB00113500": {
"PMID": 9670815,
"ISBN": null,
"volume": "20",
"issue": "5",
"year": 1998,
"title": "Phosphatidylinositol transfer proteins: a requirement in signal transduction and vesicle traffic.",
"URL": null,
"raw_pages": "423-32",
"medline_journal": "Bioessays",
"ISO_journal": "Bioessays",
"authors": [
"Cockcroft S."
],
"DOI_URL": null
},
"PUB00113499": {
"PMID": 2215682,
"ISBN": null,
"volume": "347",
"issue": "6293",
"year": 1990,
"title": "An essential role for a phospholipid transfer protein in yeast Golgi function.",
"URL": null,
"raw_pages": "561-2",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Bankaitis VA",
"Aitken JR",
"Cleves AE",
"Dowhan W."
],
"DOI_URL": null
},
"PUB00113497": {
"PMID": 8034733,
"ISBN": null,
"volume": "269",
"issue": "30",
"year": 1994,
"title": "Characterization of two structurally related Xenopus laevis protein tyrosine phosphatases with homology to lipid-binding proteins.",
"URL": null,
"raw_pages": "19639-45",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Del Vecchio RL",
"Tonks NK."
],
"DOI_URL": null
},
"PUB00113496": {
"PMID": 9529254,
"ISBN": null,
"volume": "92",
"issue": "6",
"year": 1998,
"title": "UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.",
"URL": null,
"raw_pages": "785-95",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Steven R",
"Kubiseski TJ",
"Zheng H",
"Kulkarni S",
"Mancillas J",
"Ruiz Morales A",
"Hogue CW",
"Pawson T",
"Culotti J."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl15787",
"name": "SEC14"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 92871,
"pathways": 0,
"proteins": 92343,
"proteomes": 3375,
"sets": 1,
"structural_models": {
"alphafold": 75034,
"bfvd": 1
},
"structures": 70,
"taxa": 9954
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "7ur2",
"name": "Crystal structure of the Sec14 domain of the RhoGEF Kalirin"
}
}
}
