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{
    "metadata": {
        "accession": "IPR058028",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF25827": "Tepsin VHS/ENTH-like domain"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR058028",
            "name": "AP-4 complex accessory subunit Tepsin, VHS/ENTH-like domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "AP-4 complex accessory subunit Tepsin, VHS/ENTH-like domain",
            "short": "Tepsin_VHS/ENTH-like"
        },
        "description": [
            {
                "text": "<p>This entry describes the VHS/ENTH-like domain found in human AP-4 complex accessory subunit Tepsin and similar animal proteins. The Epsin N-Terminal Homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. ENTH is structurally similar to the VHS domain and is composed of a superhelix of eight α-helices. ENTH domains bind both, inositol phospholipids and proteins. They contribute to the nucleation and formation of clathrin coats on membranes [[cite:PUB00086426]]. Tepsin associates with the Adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network [[cite:PUB00086230]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00086230": {
                "PMID": 26542808,
                "ISBN": null,
                "volume": "290",
                "issue": "52",
                "year": 2015,
                "title": "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex.",
                "URL": null,
                "raw_pages": "30736-49",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J. Biol. Chem.",
                "authors": [
                    "Mattera R",
                    "Guardia CM",
                    "Sidhu SS",
                    "Bonifacino JS."
                ],
                "DOI_URL": "https://doi.org/10.1074/jbc.M115.683409"
            },
            "PUB00086426": {
                "PMID": 28691777,
                "ISBN": null,
                "volume": null,
                "issue": null,
                "year": 2017,
                "title": "Structure and evolution of ENTH and VHS/ENTH-like domains in tepsin.",
                "URL": null,
                "raw_pages": null,
                "medline_journal": "Traffic",
                "ISO_journal": "Traffic",
                "authors": [
                    "Archuleta TL",
                    "Frazier MN",
                    "Monken AE",
                    "Kendall AK",
                    "Harp J",
                    "McCoy AJ",
                    "Creanza N",
                    "Jackson LP."
                ],
                "DOI_URL": "https://doi.org/10.1111/tra.12499"
            },
            "PUB00089789": {
                "PMID": 23771894,
                "ISBN": null,
                "volume": "25",
                "issue": "6",
                "year": 2013,
                "title": "MTV1 and MTV4 encode plant-specific ENTH and ARF GAP proteins that mediate clathrin-dependent trafficking of vacuolar cargo from the trans-Golgi network.",
                "URL": null,
                "raw_pages": "2217-35",
                "medline_journal": "Plant Cell",
                "ISO_journal": "Plant Cell",
                "authors": [
                    "Sauer M",
                    "Delgadillo MO",
                    "Zouhar J",
                    "Reynolds GD",
                    "Pennington JG",
                    "Jiang L",
                    "Liljegren SJ",
                    "Stierhof YD",
                    "De Jaeger G",
                    "Otegui MS",
                    "Bednarek SY",
                    "Rojo E."
                ],
                "DOI_URL": "https://doi.org/10.1105/tpc.113.111724"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 11,
            "interactions": 0,
            "matches": 1166,
            "pathways": 0,
            "proteins": 1151,
            "proteomes": 693,
            "sets": 0,
            "structural_models": {
                "alphafold": 1046,
                "bfvd": 0
            },
            "structures": 3,
            "taxa": 2354
        },
        "entry_annotations": {
            "alignment:seed": 27,
            "alignment:full": 883
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "5wf2",
            "name": "Tepsin VHS/ENTH-like Native"
        }
    }
}