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{
    "metadata": {
        "accession": "IPR055201",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF22525": "S13-like H2TH domain"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR055201",
            "name": "Integration host factor-like, helix-two turn-helix domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "Integration host factor-like, helix-two turn-helix domain",
            "short": "IHF-like_H2TH"
        },
        "description": [
            {
                "text": "<p>This entry represents helix-two turn-helix (H2TH) domains found in Integration host factor from Streptomyces coelicolor (IHF) and similar proteins mainly found in actinomycetes. IHF is a nucleoid-associated protein (NAP) that probably plays a role in chromosome compactation. It contributes to development and secondary metabolism, but is dispensable for growth and viability [[cite:PUB00154908], [cite:PUB00065099], [cite:PUB00151044]]. This domain is also found at the N-terminal of guanylate kinases.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00151044": {
                "PMID": 31376411,
                "ISBN": null,
                "volume": "1863",
                "issue": "11",
                "year": 2019,
                "title": "Streptomyces IHF uses multiple interfaces to bind DNA.",
                "URL": null,
                "raw_pages": "129405",
                "medline_journal": "Biochim Biophys Acta Gen Subj",
                "ISO_journal": "Biochim Biophys Acta Gen Subj",
                "authors": [
                    "Nanji T",
                    "Gehrke EJ",
                    "Shen Y",
                    "Gloyd M",
                    "Zhang X",
                    "Firby CD",
                    "Huynh A",
                    "Razi A",
                    "Ortega J",
                    "Elliot MA",
                    "Guarne A."
                ],
                "DOI_URL": null
            },
            "PUB00065099": {
                "PMID": 23427309,
                "ISBN": null,
                "volume": null,
                "issue": null,
                "year": 2013,
                "title": "A novel nucleoid-associated protein specific to the actinobacteria.",
                "URL": null,
                "raw_pages": null,
                "medline_journal": "Nucleic Acids Res",
                "ISO_journal": "Nucleic Acids Res.",
                "authors": [
                    "Swiercz JP",
                    "Nanji T",
                    "Gloyd M",
                    "Guarne A",
                    "Elliot MA."
                ],
                "DOI_URL": null
            },
            "PUB00154908": {
                "PMID": 22038127,
                "ISBN": null,
                "volume": "101",
                "issue": "3",
                "year": 2012,
                "title": "A novel function of Streptomyces integration host factor (sIHF) in the control of antibiotic production and sporulation in Streptomyces coelicolor.",
                "URL": null,
                "raw_pages": "479-92",
                "medline_journal": "Antonie Van Leeuwenhoek",
                "ISO_journal": "Antonie Van Leeuwenhoek",
                "authors": [
                    "Yang YH",
                    "Song E",
                    "Willemse J",
                    "Park SH",
                    "Kim WS",
                    "Kim EJ",
                    "Lee BR",
                    "Kim JN",
                    "van Wezel GP",
                    "Kim BG."
                ],
                "DOI_URL": "https://doi.org/10.1007/s10482-011-9657-z"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 6,
            "interactions": 0,
            "matches": 5011,
            "pathways": 0,
            "proteins": 5011,
            "proteomes": 3686,
            "sets": 0,
            "structural_models": {
                "alphafold": 3294,
                "bfvd": 2
            },
            "structures": 3,
            "taxa": 4850
        },
        "entry_annotations": {
            "alignment:seed": 26,
            "alignment:full": 2137
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "6bek",
            "name": "Structure of sIHF bound to an 8bp palindromic DNA"
        }
    }
}