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{
    "metadata": {
        "accession": "IPR055168",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF22338": "Pyruvate-ferredoxin oxidoreductase, insertion domain"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR055168",
            "name": "Pyruvate-ferredoxin oxidoreductase, insertion domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "Pyruvate-ferredoxin oxidoreductase, insertion domain",
            "short": "Pyruv_OxRed_insertion"
        },
        "description": [
            {
                "text": "<p>This entry represents the insertion domain of Pyruvate-flavodoxin oxidoreductase from Desulfocurvibacter africanus (Por) and similar bacterial sequences. Por catalyses the ferredoxin-dependent oxidative decarboxylation of pyruvate required for the transfer of electrons from pyruvate to ferredoxin [[cite:PUB00154895], [cite:PUB00074318]]. This domain adopts a four helical bundle fold.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00074318": {
                "PMID": 9294422,
                "ISBN": null,
                "volume": "179",
                "issue": "18",
                "year": 1997,
                "title": "Isolation and analysis of the gene encoding the pyruvate-ferredoxin oxidoreductase of Desulfovibrio africanus, production of the recombinant enzyme in Escherichia coli, and effect of carboxy-terminal deletions on its stability.",
                "URL": null,
                "raw_pages": "5684-92",
                "medline_journal": "J Bacteriol",
                "ISO_journal": "J. Bacteriol.",
                "authors": [
                    "Pieulle L",
                    "Magro V",
                    "Hatchikian EC."
                ],
                "DOI_URL": null
            },
            "PUB00154895": {
                "PMID": 7612653,
                "ISBN": null,
                "volume": "1250",
                "issue": "1",
                "year": 1995,
                "title": "Isolation and characterization of the pyruvate-ferredoxin oxidoreductase from the sulfate-reducing bacterium Desulfovibrio africanus.",
                "URL": null,
                "raw_pages": "49-59",
                "medline_journal": "Biochim Biophys Acta",
                "ISO_journal": "Biochim Biophys Acta",
                "authors": [
                    "Pieulle L",
                    "Guigliarelli B",
                    "Asso M",
                    "Dole F",
                    "Bernadac A",
                    "Hatchikian EC."
                ],
                "DOI_URL": "https://doi.org/10.1016/0167-4838(95)00029-t"
            },
            "PUB00154189": {
                "PMID": 29581263,
                "ISBN": null,
                "volume": "115",
                "issue": "15",
                "year": 2018,
                "title": "Binding site for coenzyme A revealed in the structure of pyruvate:ferredoxin oxidoreductase from <i>Moorella thermoacetica</i>.",
                "URL": null,
                "raw_pages": "3846-3851",
                "medline_journal": "Proc Natl Acad Sci U S A",
                "ISO_journal": "Proc Natl Acad Sci U S A",
                "authors": [
                    "Chen PY",
                    "Aman H",
                    "Can M",
                    "Ragsdale SW",
                    "Drennan CL."
                ],
                "DOI_URL": "https://doi.org/10.1073/pnas.1722329115"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR029061",
                "name": "Thiamin diphosphate-binding fold",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 39,
            "interactions": 0,
            "matches": 1065,
            "pathways": 0,
            "proteins": 1065,
            "proteomes": 564,
            "sets": 0,
            "structural_models": {
                "alphafold": 861,
                "bfvd": 0
            },
            "structures": 15,
            "taxa": 1442
        },
        "entry_annotations": {
            "alignment:seed": 19,
            "alignment:full": 465
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}