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{
    "metadata": {
        "accession": "IPR051630",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR14017": "Transcriptional Corepressor and Histone Demethylase"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR051630",
            "name": "Transcriptional Corepressor and Histone Demethylase",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Transcriptional Corepressor and Histone Demethylase",
            "short": "Corepressor-Demethylase"
        },
        "description": [
            {
                "text": "<p>This family of proteins includes transcriptional corepressors and histone demethylases. The corepressors are involved in gene repression through the formation of complexes that recruit histone deacetylases, leading to a repressive chromatin structure and direct interference with the transcriptional machinery. They play roles in various physiological processes and are essential for normal growth and development. The histone demethylases are involved in the dynamic regulation of histone methylation, specifically demethylating 'Lys-27' of histone H3, which is a key modification in the histone code. These enzymes are implicated in developmental processes by regulating HOX gene expression, and they also participate in inflammatory responses and macrophage differentiation. Some members of this family have additional roles in chromatin remodeling independent of their demethylase activity.</p>",
                "llm": true,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": null,
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR046941",
                "name": "Lysine-specific demethylase 6, GATA-like domain superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 8950,
            "pathways": 19,
            "proteins": 8950,
            "proteomes": 2716,
            "sets": 0,
            "structural_models": {
                "alphafold": 4553,
                "bfvd": 0
            },
            "structures": 27,
            "taxa": 7621
        },
        "entry_annotations": {},
        "cross_references": {
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "1.14.11.68",
                        "url": "https://enzyme.expasy.org/EC/1.14.11.68"
                    }
                ]
            }
        },
        "is_llm": true,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "2xxz",
            "name": "Crystal structure of the human JMJD3 jumonji domain"
        }
    }
}