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{
    "metadata": {
        "accession": "IPR051566",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR12844": "Connector enhancer of kinase suppressor of Ras"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR051566",
            "name": "Connector enhancer of kinase suppressor of Ras",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Connector enhancer of kinase suppressor of Ras",
            "short": "CNKSR"
        },
        "description": [
            {
                "text": "<p>The CNKSR family proteins function as adapter or scaffold proteins involved in various signaling pathways. They enhance guanine-nucleotide exchange on ARF6, regulate Ras signaling, and are implicated in cell migration and transepithelial sodium transport. The family members coordinate the assembly of protein complexes, such as the ENaC-regulatory complex (ERC), and are involved in the regulation of cell surface expression of channels like ENaC. Their roles are essential in processes like HGF-dependent activation of Arf6 and aldosterone-induced sodium transport, contributing to cellular responses to external stimuli and intracellular signaling.</p>",
                "llm": true,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": null,
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 8267,
            "pathways": 10,
            "proteins": 8267,
            "proteomes": 1253,
            "sets": 0,
            "structural_models": {
                "alphafold": 7271,
                "bfvd": 0
            },
            "structures": 7,
            "taxa": 4283
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": true,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "3bs5",
            "name": "Crystal Structure of hCNK2-SAM/dHYP-SAM Complex"
        }
    }
}