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{
"metadata": {
"accession": "IPR050699",
"entry_id": null,
"type": "family",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"panther": {
"PTHR12131": "RNA/DNA Helicase"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR050699",
"name": "ATP-dependent RNA helicase SUPV3-like",
"type": "Family",
"children": [
{
"accession": "IPR016438",
"name": "Circadian oscillator component FRH-like",
"type": "Family",
"children": []
}
]
},
"name": {
"name": "ATP-dependent RNA helicase SUPV3-like",
"short": "SUPV3-like"
},
"description": [
{
"text": "<p>This entry represents ATP-dependent RNA helicase SUPV3L1, mitochondrial and related ATP-dependent RNA helicases found in bacteria and eukaryotes including Probable helicase HelY from bacteria.</p>",
"llm": true,
"checked": true,
"updated": true
},
{
"text": "<p>SUPV3L1 is a major helicase involved in mitochondrial RNA metabolism. It is a component of the mitochondrial degradosome (mtEXO) complex, which degrades 3' overhang double-stranded RNA with 3'-to-5' directionality in an ATP-dependent manner [[cite:PUB00095346]]. SUPV3L1 functions as an ATPase and ATP-dependent multisubstrate helicase, capable of unwinding double-stranded DNA, double-stranded RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. The protein plays a central role in the mitochondrial RNA surveillance system, regulating the stability of mature mRNAs, removing aberrantly formed mRNAs, and rapidly degrading non-coding processing intermediates, including non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules [[cite:PUB00095346]]. SUPV3L1 is also implicated in recombination and chromatin maintenance pathways, associates with mitochondrial DNA, and may protect cells from apoptosis.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00095346": {
"PMID": 29967381,
"ISBN": null,
"volume": "9",
"issue": "1",
"year": 2018,
"title": "Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria.",
"URL": null,
"raw_pages": "2558",
"medline_journal": "Nat Commun",
"ISO_journal": "Nat Commun",
"authors": [
"Pietras Z",
"Wojcik MA",
"Borowski LS",
"Szewczyk M",
"Kulinski TM",
"Cysewski D",
"Stepien PP",
"Dziembowski A",
"Szczesny RJ."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 33889,
"pathways": 19,
"proteins": 33889,
"proteomes": 10967,
"sets": 0,
"structural_models": {
"alphafold": 25542,
"bfvd": 3
},
"structures": 48,
"taxa": 21322
},
"entry_annotations": {},
"cross_references": {
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "3.6.4.13",
"url": "https://enzyme.expasy.org/EC/3.6.4.13"
}
]
}
},
"is_llm": true,
"is_reviewed_llm": true,
"is_updated_llm": true,
"representative_structure": null
}
}
