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{
    "metadata": {
        "accession": "IPR050607",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR43410": "Nitric Oxide Synthase (NOS)"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR050607",
            "name": "Nitric Oxide Synthase (NOS)",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Nitric Oxide Synthase (NOS)",
            "short": "NOS"
        },
        "description": [
            {
                "text": "<p>The Nitric Oxide Synthase (NOS) family is responsible for the production of nitric oxide (NO), a versatile messenger molecule with a wide range of biological functions. Members of the NOS family catalyze the conversion of L-arginine to L-citrulline, releasing NO in the process. NO plays a critical role in various physiological processes including neurotransmission, vascular smooth muscle relaxation, immune response, and regulation of gene expression. The family includes inducible forms that are stimulated by inflammatory signals and constitutive forms that are regulated by calcium/calmodulin. Some NOS proteins also exhibit nitrosylase activity, mediating the S-nitrosylation of cytoplasmic target proteins, which can affect their function and activity.</p>",
                "llm": true,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": null,
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR036119",
                "name": "Nitric oxide synthase, N-terminal domain superfamily",
                "type": "homologous_superfamily"
            },
            {
                "accession": "IPR044943",
                "name": "Nitric oxide synthase, domain 1 superfamily",
                "type": "homologous_superfamily"
            },
            {
                "accession": "IPR044940",
                "name": "Nitric oxide synthase, domain 2 superfamily",
                "type": "homologous_superfamily"
            },
            {
                "accession": "IPR044944",
                "name": "Nitric oxide synthase, domain 3 superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 8197,
            "pathways": 49,
            "proteins": 8197,
            "proteomes": 3066,
            "sets": 0,
            "structural_models": {
                "alphafold": 5699,
                "bfvd": 0
            },
            "structures": 800,
            "taxa": 7137
        },
        "entry_annotations": {},
        "cross_references": {
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "1.14.13.39",
                        "url": "https://enzyme.expasy.org/EC/1.14.13.39"
                    }
                ]
            }
        },
        "is_llm": true,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "6cid",
            "name": "Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with N-(1-(Piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide"
        }
    }
}