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{
    "metadata": {
        "accession": "IPR050477",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR42735": "Group II Amino Acid Decarboxylases"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR050477",
            "name": "Group II Amino Acid Decarboxylases",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Group II Amino Acid Decarboxylases",
            "short": "GrpII_AminoAcid_Decarb"
        },
        "description": [
            {
                "text": "<p>The Group II Decarboxylase family comprises enzymes that catalyse the decarboxylation of various amino acids, playing key roles in metabolic pathways. Members of the MfnA subfamily primarily decarboxylate L-tyrosine and L-aspartate, contributing to methanofuran biosynthesis and coenzyme A production, respectively. The Sphingosine-1-phosphate lyase subfamily members cleave phosphorylated sphingoid bases into fatty aldehydes and phosphoethanolamine, impacting lipid homeostasis, apoptosis, and stress responses. The Tyrosine decarboxylase subfamily is involved in tyramine production, which aids in acid resistance and gastrointestinal colonisation, and can metabolize levodopa, affecting Parkinson's disease treatment. Other family members, such as Tryptophan decarboxylase, are involved in neurotransmitter synthesis. The family's diverse functions reflect its importance in various biological processes, including neurotransmission, stress response, lipid metabolism, and drug metabolism.</p>",
                "llm": true,
                "checked": true,
                "updated": true
            }
        ],
        "wikipedia": null,
        "literature": null,
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR015424",
                "name": "Pyridoxal phosphate-dependent transferase",
                "type": "homologous_superfamily"
            },
            {
                "accession": "IPR015421",
                "name": "Pyridoxal phosphate-dependent transferase, major domain",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 12744,
            "pathways": 7,
            "proteins": 12744,
            "proteomes": 5799,
            "sets": 0,
            "structural_models": {
                "alphafold": 10971,
                "bfvd": 2
            },
            "structures": 26,
            "taxa": 13671
        },
        "entry_annotations": {},
        "cross_references": {
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "4.1.1",
                        "url": "https://enzyme.expasy.org/EC/4.1.1"
                    }
                ]
            }
        },
        "is_llm": true,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "6jy1",
            "name": "Crystal Structure of a Group II pyridoxal dependent decarboxylase, LLP-bound form from Methanocaldococcus jannaschii at 1.72 A"
        }
    }
}