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{
    "metadata": {
        "accession": "IPR050275",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR48100": "Phosphoglycerate Mutase/Phosphatase"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR050275",
            "name": "Phosphoglycerate Mutase/Phosphatase",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Phosphoglycerate Mutase/Phosphatase",
            "short": "PGM_Phosphatase"
        },
        "description": [
            {
                "text": "<p>The phosphoglycerate mutase family is involved in various metabolic processes, including glycolysis and gluconeogenesis, by catalyzing the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Some members exhibit phosphatase activity, participating in the biosynthesis of compounds like mycobacterial methylglucose lipopolysaccharides or in the dephosphorylation of specific phosphosugars. Others have evolved to acquire specialized functions, such as the regulation of carbohydrate metabolism, involvement in serine biosynthesis, or the hydrolysis of phospho groups from vitamin B12 intermediates. The family also includes proteins with broader substrate specificity, acting on various phosphorylated compounds but lacking phosphoglycerate mutase activity. Collectively, the family plays a crucial role in carbohydrate metabolism and other biosynthetic pathways, with some members also implicated in stress response and immune modulation.</p>",
                "llm": true,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": null,
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR029033",
                "name": "Histidine phosphatase superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 72557,
            "pathways": 0,
            "proteins": 72557,
            "proteomes": 15898,
            "sets": 0,
            "structural_models": {
                "alphafold": 55935,
                "bfvd": 8
            },
            "structures": 49,
            "taxa": 28316
        },
        "entry_annotations": {},
        "cross_references": {
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "5.4.2.-",
                        "url": "https://enzyme.expasy.org/EC/5.4.2.-"
                    }
                ]
            }
        },
        "is_llm": true,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "1h2e",
            "name": "BACILLUS STEAROTHERMOPHILUS PHOE (previously known as yhfr) in complex with phosphate"
        }
    }
}