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{
    "metadata": {
        "accession": "IPR049489",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF21607": "[Acyl-carrier-protein] S-malonyltransferase, inserted helical domain"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR049489",
            "name": "[Acyl-carrier-protein] S-malonyltransferase-like, inserted helical domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "[Acyl-carrier-protein] S-malonyltransferase-like, inserted helical domain",
            "short": "FabD-like_helical_ins"
        },
        "description": [
            {
                "text": "<p>This domain is found in the C-terminal region of [Acyl-carrier-protein] S-malonyltransferase from Bacillus velezensis (FabD, [swissprot:A7Z6E3]) and similar bacterial proteins. FabD, a marine polyunsaturated fatty acid (PUFA) synthase involved in difficidin A biosynthesis, is organised into two domains: anacetyl-transferase (AT) domain ([interpro:IPR014043]) and an enoyl reductase (ER) domain that consists of a TIM-barrel domain ([interpro:IPR004136]) and an inserted α-helical substrate-binding domain (this entry) [[cite:PUB00152727]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00152727": {
                "PMID": 25456814,
                "ISBN": null,
                "volume": "22",
                "issue": "12",
                "year": 2014,
                "title": "Evolutionary origins of the multienzyme architecture of giant fungal fatty acid synthase.",
                "URL": null,
                "raw_pages": "1775-1785",
                "medline_journal": "Structure",
                "ISO_journal": "Structure",
                "authors": [
                    "Bukhari HST",
                    "Jakob RP",
                    "Maier T."
                ],
                "DOI_URL": "https://doi.org/10.1016/j.str.2014.09.016"
            },
            "PUB00152726": {
                "PMID": 33587627,
                "ISBN": null,
                "volume": "69",
                "issue": "7",
                "year": 2021,
                "title": "Structural Insights into the <i>Trans</i>-Acting Enoyl Reductase in the Biosynthesis of Long-Chain Polyunsaturated Fatty Acids in <i>Shewanella piezotolerans</i>.",
                "URL": null,
                "raw_pages": "2316-2324",
                "medline_journal": "J Agric Food Chem",
                "ISO_journal": "J Agric Food Chem",
                "authors": [
                    "Zhang M",
                    "Zhang H",
                    "Li Q",
                    "Gao Y",
                    "Guo L",
                    "He L",
                    "Zang S",
                    "Guo X",
                    "Huang J",
                    "Li L."
                ],
                "DOI_URL": "https://doi.org/10.1021/acs.jafc.0c07386"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 39,
            "interactions": 0,
            "matches": 1757,
            "pathways": 6,
            "proteins": 1756,
            "proteomes": 1074,
            "sets": 0,
            "structural_models": {
                "alphafold": 1198,
                "bfvd": 0
            },
            "structures": 5,
            "taxa": 2254
        },
        "entry_annotations": {
            "alignment:seed": 122,
            "alignment:full": 668
        },
        "cross_references": {
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "2.3.1.39",
                        "url": "https://enzyme.expasy.org/EC/2.3.1.39"
                    }
                ]
            }
        },
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}