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{
"metadata": {
"accession": "IPR049440",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"pfam": {
"PF21363": "TNF receptor-associated factor 2/3/5, RING domain"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001841",
"name": "Zinc finger, RING-type",
"type": "Domain",
"children": [
{
"accession": "IPR018957",
"name": "Zinc finger, C3HC4 RING-type",
"type": "Domain",
"children": [
{
"accession": "IPR045859",
"name": "Peroxisome biogenesis factor 2, HC subclass-RING finger domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR058558",
"name": "V(D)J recombination-activating protein 1, RING finger, HC subclass",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR024766",
"name": "Zinc finger, RING-H2-type",
"type": "Domain",
"children": []
},
{
"accession": "IPR024991",
"name": "Anaphase-promoting complex subunit 11, RING-H2 finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR027133",
"name": "TNF receptor-associated factor 2, C3HC3D-type RING zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR027139",
"name": "TNF receptor-associated factor 6, C3HC3D-type RING zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR027370",
"name": "Zinc finger, RING-type, eukaryotic",
"type": "Domain",
"children": [
{
"accession": "IPR027726",
"name": "E3 ubiquitin-protein ligase Trim36, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR033491",
"name": "Probable E3 ubiquitin-protein ligase MID2, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042667",
"name": "E3 ubiquitin-protein ligase TRIM63, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042716",
"name": "E3 ubiquitin-protein ligase RNF114, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042752",
"name": "TRIM54, RING finger, HC subclass",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR027934",
"name": "Cellulose synthase, RING-type zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR028511",
"name": "E3 ubiquitin-protein ligase SH3RF2, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR032043",
"name": "E3 ubiquitin-protein ligase Msl2, zinc RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR033609",
"name": "E3 ubiquitin-protein ligase RNF152, RING finger domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035691",
"name": "ORC ubiquitin ligase 1, RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR039503",
"name": "BARD1, Zinc finger, RING-type",
"type": "Domain",
"children": []
},
{
"accession": "IPR039520",
"name": "E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR039571",
"name": "RNF126, RING finger, H2 subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR039804",
"name": "Listerin, zinc finger, RING-type",
"type": "Domain",
"children": []
},
{
"accession": "IPR040089",
"name": "RNF26, C3HC5-type zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR040100",
"name": "RING finger protein 208, HC type RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR040178",
"name": "E3 ubiquitin-protein ligase RNF220, RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR040380",
"name": "HAKAI-like, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR041888",
"name": "ZN598/HEL22, RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR042656",
"name": "E3 ubiquitin-protein ligase TRIM68, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042699",
"name": "E3 ubiquitin-protein ligase TRIM58, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042712",
"name": "E3 ubiquitin-protein ligase RNF149, RING finger, H2 subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042713",
"name": "TIF1-beta, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042741",
"name": "RING1 , RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042765",
"name": "TRIM42, RING-HC finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR042784",
"name": "TRIM10, RING-HC finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR042823",
"name": "E3 ubiquitin-protein ligase Dma1/Dma2, RING finger, H2 subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR042843",
"name": "DTX3L, RING-HC finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR043295",
"name": "RNF4, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR043400",
"name": "RNF141, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR044080",
"name": "MDM2, modified RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR044110",
"name": "RNF146, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR045195",
"name": "LOG2-like, modified RING finger, C3HC5-type",
"type": "Domain",
"children": []
},
{
"accession": "IPR045317",
"name": "E3 ubiquitin-protein ligase RGLG1/2, RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR045903",
"name": "E3 ubiquitin-protein ligase ZNRF3, zinc finger, RING-type",
"type": "Domain",
"children": []
},
{
"accession": "IPR045907",
"name": "E3 ubiquitin-protein ligase RNF43, Zinc finger, RING-type",
"type": "Domain",
"children": []
},
{
"accession": "IPR047243",
"name": "BRCA1-associated protein, RING finger, H2 subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR047466",
"name": "E3 ubiquitin-protein ligase UHRF2, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR047498",
"name": "E3 ubiquitin-protein ligase ORTHRUS 1/2-like, first RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR047529",
"name": "E3 ubiquitin-protein ligase ORTHRUS 1-5, second RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR047559",
"name": "Heme-oxidized IRP2 ubiquitin ligase 1, modified RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR047563",
"name": "Ankyrin repeat and IBR domain-containing protein 1, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR047823",
"name": "RNF145, RING finger, H2 subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR047986",
"name": "E3 ubiquitin-protein ligase RNF182, RING finger, HC subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR048025",
"name": "RING finger protein 24, RING finger, H2 subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR048217",
"name": "RING-type E3 ubiquitin transferase BIG BROTHER, RING finger, H2 subclass",
"type": "Domain",
"children": []
},
{
"accession": "IPR049440",
"name": "TNF receptor-associated factor 3/5, RING domain",
"type": "Domain",
"children": [
{
"accession": "IPR027128",
"name": "TNF receptor-associated factor 3, C3HC3D-type RING zinc finger",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR049548",
"name": "E3 ubiquitin-protein ligase Sina-like, RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR056760",
"name": "E3 ubiquitin-protein ligase XB3-like, RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR056939",
"name": "Vps8, RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR058051",
"name": "Synoviolin-like, RING finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR058746",
"name": "Topors, zinc finger, RING-type",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "TNF receptor-associated factor 3/5, RING domain",
"short": "TRAF3/5_RING"
},
"description": [
{
"text": "<p>This is the RING domain of TNF receptor-associated factors 3 and 5 (TRAF3/5). The RING domain is common among ubiquitin E3 ligases and it is found at the N-terminal of TRAFs, followed by a series of zinc fingers and a C-terminal MATH/TRAF domain. This domain, together with the zinc fingers, is required for ligase activity [[cite:PUB00151766], [cite:PUB00151767]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00151766": {
"PMID": 29176576,
"ISBN": null,
"volume": "8",
"issue": "1",
"year": 2017,
"title": "The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1.",
"URL": null,
"raw_pages": "1788",
"medline_journal": "Nat Commun",
"ISO_journal": "Nat Commun",
"authors": [
"Middleton AJ",
"Budhidarmo R",
"Das A",
"Zhu J",
"Foglizzo M",
"Mace PD",
"Day CL."
],
"DOI_URL": null
},
"PUB00151767": {
"PMID": 33539883,
"ISBN": null,
"volume": "433",
"issue": "8",
"year": 2021,
"title": "The Structure and Ubiquitin Binding Properties of TRAF RING Heterodimers.",
"URL": null,
"raw_pages": "166844",
"medline_journal": "J Mol Biol",
"ISO_journal": "J Mol Biol",
"authors": [
"Das A",
"Middleton AJ",
"Padala P",
"Ledgerwood EC",
"Mace PD",
"Day CL."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR013083",
"name": "Zinc finger, RING/FYVE/PHD-type",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 38,
"interactions": 0,
"matches": 2262,
"pathways": 17,
"proteins": 2261,
"proteomes": 770,
"sets": 0,
"structural_models": {
"alphafold": 2113,
"bfvd": 0
},
"structures": 2,
"taxa": 2496
},
"entry_annotations": {
"alignment:seed": 1,
"alignment:full": 1806
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
