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{
    "metadata": {
        "accession": "IPR048827",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF21284": "Complement component C7, FIM2 N-terminal"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR048827",
            "name": "Complement component C7, FIM2 N-terminal domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "Complement component C7, FIM2 N-terminal domain",
            "short": "C7_FIM2_N"
        },
        "description": [
            {
                "text": "<p>Factor I-like modules (FIMs) are present in complement proteins C6, C7, and factor I, and participate in protein-protein interactions that critical to the progress of a complement-mediated immune response. Complement component C7 contains a FIM pair at the C-terminal, FIM1 and FIM2; each of them consists of a small N-terminal FOLN subdomain and a larger C-terminal KAZAL domain [[cite:PUB00050111]]. This entry represents the N-terminal of FIM2; it has a FOLN architecture which is a truncated form of the epidermal growth factor domain (EGF) [[cite:PUB00050111]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00050111": {
                "PMID": 19419965,
                "ISBN": null,
                "volume": "284",
                "issue": "29",
                "year": 2009,
                "title": "Solution Structure of Factor I-like Modules from Complement C7 Reveals a Pair of Follistatin Domains in Compact Pseudosymmetric Arrangement.",
                "URL": null,
                "raw_pages": "19637-49",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J. Biol. Chem.",
                "authors": [
                    "Phelan MM",
                    "Thai CT",
                    "Soares DC",
                    "Ogata RT",
                    "Barlow PN",
                    "Bramham J."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 22,
            "interactions": 0,
            "matches": 371,
            "pathways": 4,
            "proteins": 371,
            "proteomes": 184,
            "sets": 0,
            "structural_models": {
                "alphafold": 324,
                "bfvd": 0
            },
            "structures": 8,
            "taxa": 626
        },
        "entry_annotations": {
            "alignment:seed": 7,
            "alignment:full": 250
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}