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InterPro-Version: 108.0
InterPro-Version-Minor: 0
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{
"metadata": {
"accession": "IPR048420",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0008270",
"name": "zinc ion binding",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"source_database": "interpro",
"member_databases": {
"pfam": {
"PF21816": "Zap1, C2H2 zinc finger 1"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR013087",
"name": "Zinc finger C2H2-type",
"type": "Domain",
"children": [
{
"accession": "IPR003604",
"name": "Matrin/U1-C-like, C2H2-type zinc finger",
"type": "Domain",
"children": [
{
"accession": "IPR000690",
"name": "Matrin/U1-C, C2H2-type zinc finger",
"type": "Domain",
"children": [
{
"accession": "IPR013085",
"name": "U1-C, C2H2-type zinc finger",
"type": "Domain",
"children": []
}
]
}
]
},
{
"accession": "IPR022755",
"name": "Zinc finger, double-stranded RNA binding",
"type": "Domain",
"children": []
},
{
"accession": "IPR031514",
"name": "Aberrant zinc-finger domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034729",
"name": "Zinc finger CCHC HIVEP-type",
"type": "Domain",
"children": []
},
{
"accession": "IPR034731",
"name": "Zinc finger CCHC FOG-type",
"type": "Domain",
"children": []
},
{
"accession": "IPR041057",
"name": "ZHX, C2H2 finger domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR048403",
"name": "Zinc finger 512, zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR048414",
"name": "Histone-lysine N-methyltransferase PRDM9-like, C2H2 zinc finger-like",
"type": "Domain",
"children": []
},
{
"accession": "IPR048420",
"name": "Zap1-like, C2H2 zinc finger 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR049009",
"name": "Protein arginine N-methyltransferase 3, C2H2 zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR054177",
"name": "Uncharacterized protein B-129, C2H2 zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR055186",
"name": "BIRD-IDD transcription factor, second C2H2 zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR055187",
"name": "BIRD-IDD transcription factor, third C2HC zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR056380",
"name": "ASCIZ, forth C2H2 zinc finger domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR056436",
"name": "ZIC1-5/GLI1-3like, C2H2 zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR056438",
"name": "CTCF-like, C2H2 zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR056545",
"name": "ASCIZ, first and second C2H2 zinc finger domains",
"type": "Domain",
"children": []
},
{
"accession": "IPR057829",
"name": "ZNF142, C2H2 zinc finger 21/23",
"type": "Domain",
"children": []
},
{
"accession": "IPR059009",
"name": "C2H2-domain containing protein, first zinc finger domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR059042",
"name": "ZNF598, C2H2 zinc finger domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR059058",
"name": "Zinc finger protein 462, C2H2 zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR059059",
"name": "Zinc finger protein 462-like, seventh C2H2 zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR059074",
"name": "Z280C/D-like, C2H2 zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR059095",
"name": "C2H2-domain containing protein, second zinc finger domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR060130",
"name": "CASZ1-like, zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR060750",
"name": "Tri6-like, C2H2 zinc finger domain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "Zap1-like, C2H2 zinc finger 1",
"short": "Zap1-like_Znf1"
},
"description": [
{
"text": "<p>Zap1 transcription factor ([swissprot:P47043]) controls the expression of genes that regulate zinc homeostasis in Saccharomyces cerevisiae. Zap1 contains seven classical C2H2 zinc fingers. This domain corresponds to zinc finger 1 (Znf1) which together with zinc finger 2 (Znf2) has been shown to be a responsive transcriptional activator. Both zinc fingers interact cooperatively to stabilise the Zn-binding [[cite:PUB00039045]].</p>\n\n<p>This zinc finger is also found in pH-response transcription factor pacC/RIM101 ([swissprot:P33400]) that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH [[cite:PUB00151952]].</p>\n\n<p>Proteins containing this domain are primarily found in fungi and eumetazoa.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00151952": {
"PMID": 12509465,
"ISBN": null,
"volume": "23",
"issue": "2",
"year": 2003,
"title": "The transcription factor Rim101p governs ion tolerance and cell differentiation by direct repression of the regulatory genes NRG1 and SMP1 in Saccharomyces cerevisiae.",
"URL": null,
"raw_pages": "677-86",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol Cell Biol",
"authors": [
"Lamb TM",
"Mitchell AP."
],
"DOI_URL": "https://doi.org/10.1128/MCB.23.2.677-686.2003"
},
"PUB00039045": {
"PMID": 16483601,
"ISBN": null,
"volume": "357",
"issue": "4",
"year": 2006,
"title": "Solution structure of a Zap1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae.",
"URL": null,
"raw_pages": "1167-83",
"medline_journal": "J Mol Biol",
"ISO_journal": "J. Mol. Biol.",
"authors": [
"Wang Z",
"Feng LS",
"Matskevich V",
"Venkataraman K",
"Parasuram P",
"Laity JH."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.jmb.2006.01.010"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036236",
"name": "Zinc finger C2H2 superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 60,
"interactions": 0,
"matches": 1033,
"pathways": 0,
"proteins": 1028,
"proteomes": 704,
"sets": 0,
"structural_models": {
"alphafold": 937,
"bfvd": 0
},
"structures": 1,
"taxa": 2110
},
"entry_annotations": {
"alignment:seed": 33,
"alignment:full": 831
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
