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{
"metadata": {
"accession": "IPR047410",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd20063": "Forkhead (FH) domain found in Forkhead box protein O6 (FOXO6) and similar proteins"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001766",
"name": "Fork head domain",
"type": "Domain",
"children": [
{
"accession": "IPR047364",
"name": "Forkhead box protein S1, Forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047366",
"name": "Hepatocyte nuclear factor 3-gamma, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047388",
"name": "Protein fork head-like, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047389",
"name": "Forkhead box protein B1/B2, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047391",
"name": "Forkhead box protein C1/C2-like, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047392",
"name": "Forkhead box protein D3, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047393",
"name": "Forkhead box protein J2, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047394",
"name": "Forkhead box protein K1, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047397",
"name": "Forkhead box protein K2, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047401",
"name": "Forkhead box protein N1, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047403",
"name": "Forkhead box protein N2, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047408",
"name": "Forkhead box protein O1, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047409",
"name": "Forkhead box protein O4, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047410",
"name": "Forkhead box protein O6, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047412",
"name": "Forkhead box protein P1/P2, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047413",
"name": "Forkhead box protein P3, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047414",
"name": "Forkhead box protein P4, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047511",
"name": "Forkhead box protein H1, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047512",
"name": "Forkhead box protein J1, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047514",
"name": "Forkhead box protein L1, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047515",
"name": "Forkhead box protein L2, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047516",
"name": "Forkhead box protein M1, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047518",
"name": "Forkhead box protein Q1, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047519",
"name": "Forkhead box protein Q2-like, forkhead domain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "Forkhead box protein O6, forkhead domain",
"short": "FH_FOXO6"
},
"description": [
{
"text": "<p>This entry represents the forkhead (FH) domain of human FOXO6 and similar sequences from vertebrates. The FH domain is a winged helix DNA-binding domain.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>Forkhead box protein O6 (FOXO6) is a transcriptional activator of the Hippo signaling that regulates skull growth, odontogenesis and face morphology [[cite:PUB00103037]]. FOXO6 can regulate diabetes-induced oxidative stress [[cite:PUB00103040]]. It may play an important role on tumour invasion, metastasis and prognosis [[cite:PUB00103038], [cite:PUB00103039]]. FOXO6 knockdown inhibits cell proliferation and represses the migration and invasion of colorectal cancer cells, which also alters cellular metabolism by inhibiting glycolysis and promoting mitochondrial respiration, therefore, it is a potential target for colorectal cancer therapy [[cite:PUB00103036]]. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00103036": {
"PMID": 30321450,
"ISBN": null,
"volume": "120",
"issue": "3",
"year": 2019,
"title": "Silencing of FOXO6 inhibits the proliferation, invasion, and glycolysis in colorectal cancer cells.",
"URL": null,
"raw_pages": "3853-3860",
"medline_journal": "J Cell Biochem",
"ISO_journal": "J Cell Biochem",
"authors": [
"Li Q",
"Tang H",
"Hu F",
"Qin C."
],
"DOI_URL": null
},
"PUB00103037": {
"PMID": 30286078,
"ISBN": null,
"volume": "14",
"issue": "10",
"year": 2018,
"title": "FoxO6 regulates Hippo signaling and growth of the craniofacial complex.",
"URL": null,
"raw_pages": "e1007675",
"medline_journal": "PLoS Genet",
"ISO_journal": "PLoS Genet",
"authors": [
"Sun Z",
"da Fontoura CSG",
"Moreno M",
"Holton NE",
"Sweat M",
"Sweat Y",
"Lee MK",
"Arbon J",
"Bidlack FB",
"Thedens DR",
"Nopoulos P",
"Cao H",
"Eliason S",
"Weinberg SM",
"Martin JF",
"Moreno-Uribe L",
"Amendt BA."
],
"DOI_URL": null
},
"PUB00103038": {
"PMID": 28404958,
"ISBN": null,
"volume": "8",
"issue": "19",
"year": 2017,
"title": "Elevated FOXO6 expression correlates with progression and prognosis in gastric cancer.",
"URL": null,
"raw_pages": "31682-31691",
"medline_journal": "Oncotarget",
"ISO_journal": "Oncotarget",
"authors": [
"Wang JH",
"Tang HS",
"Li XS",
"Zhang XL",
"Yang XZ",
"Zeng LS",
"Ruan Q",
"Huang YH",
"Liu GJ",
"Wang J",
"Cui SZ."
],
"DOI_URL": null
},
"PUB00103039": {
"PMID": 30464613,
"ISBN": null,
"volume": "10",
"issue": null,
"year": 2018,
"title": "Downregulation of FOXO6 in breast cancer promotes epithelial-mesenchymal transition and facilitates migration and proliferation of cancer cells.",
"URL": null,
"raw_pages": "5145-5156",
"medline_journal": "Cancer Manag Res",
"ISO_journal": "Cancer Manag Res",
"authors": [
"Ye H",
"Duan M."
],
"DOI_URL": null
},
"PUB00103040": {
"PMID": 30548643,
"ISBN": null,
"volume": "120",
"issue": "6",
"year": 2019,
"title": "Knockdown of FOXO6 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells.",
"URL": null,
"raw_pages": "9716-9723",
"medline_journal": "J Cell Biochem",
"ISO_journal": "J Cell Biochem",
"authors": [
"Zhou Z",
"Liu J",
"Bi C",
"Chen L",
"Jiao Y",
"Cui L."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036390",
"name": "Winged helix DNA-binding domain superfamily",
"type": "homologous_superfamily"
},
{
"accession": "IPR036388",
"name": "Winged helix-like DNA-binding domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 577,
"pathways": 7,
"proteins": 577,
"proteomes": 400,
"sets": 0,
"structural_models": {
"alphafold": 538,
"bfvd": 0
},
"structures": 0,
"taxa": 1397
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
