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{
"metadata": {
"accession": "IPR047364",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd20037": "Forkhead (FH) domain found in Forkhead box protein S1 (FOXS1)"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001766",
"name": "Fork head domain",
"type": "Domain",
"children": [
{
"accession": "IPR047364",
"name": "Forkhead box protein S1, Forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047366",
"name": "Hepatocyte nuclear factor 3-gamma, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047388",
"name": "Protein fork head-like, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047389",
"name": "Forkhead box protein B1/B2, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047391",
"name": "Forkhead box protein C1/C2-like, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047392",
"name": "Forkhead box protein D3, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047393",
"name": "Forkhead box protein J2, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047394",
"name": "Forkhead box protein K1, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047397",
"name": "Forkhead box protein K2, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047401",
"name": "Forkhead box protein N1, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047403",
"name": "Forkhead box protein N2, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047408",
"name": "Forkhead box protein O1, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047409",
"name": "Forkhead box protein O4, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047410",
"name": "Forkhead box protein O6, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047412",
"name": "Forkhead box protein P1/P2, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047413",
"name": "Forkhead box protein P3, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047414",
"name": "Forkhead box protein P4, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047511",
"name": "Forkhead box protein H1, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047512",
"name": "Forkhead box protein J1, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047514",
"name": "Forkhead box protein L1, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047515",
"name": "Forkhead box protein L2, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047516",
"name": "Forkhead box protein M1, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047518",
"name": "Forkhead box protein Q1, forkhead domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047519",
"name": "Forkhead box protein Q2-like, forkhead domain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "Forkhead box protein S1, Forkhead domain",
"short": "FH_FOXS1"
},
"description": [
{
"text": "<p>This entry represents the forkhead (FH) domain of human FOXS1 and similar sequences from vertebrates. The FH domain is a winged helix DNA-binding domain.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>Forkhead box protein S1 (FOXS1) is a transcriptional repressor that suppresses transcription from the FASLG, FOXO3, and FOXO4 promoters. It may have a role in the organisation of the testicular vasculature. It has also been implicated in energy turnover, motor function, and body weight [[cite:PUB00102719], [cite:PUB00102723], [cite:PUB00102718]]. Downregulation of FOXS1 has been related to cell proliferation and metastasis [[cite:PUB00102722], [cite:PUB00102721], [cite:PUB00102720]]. FOX transcription factors recognise the core sequence 5'-(A/C)AA(C/T)A-3'.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00102718": {
"PMID": 15964817,
"ISBN": null,
"volume": "25",
"issue": "13",
"year": 2005,
"title": "Lack of the central nervous system- and neural crest-expressed forkhead gene Foxs1 affects motor function and body weight.",
"URL": null,
"raw_pages": "5616-25",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol Cell Biol",
"authors": [
"Heglind M",
"Cederberg A",
"Aquino J",
"Lucas G",
"Ernfors P",
"Enerback S."
],
"DOI_URL": null
},
"PUB00102719": {
"PMID": 28199372,
"ISBN": null,
"volume": "12",
"issue": "2",
"year": 2017,
"title": "Endometrial factors similarly induced by IFNT2 and IFNTc1 through transcription factor FOXS1.",
"URL": null,
"raw_pages": "e0171858",
"medline_journal": "PLoS One",
"ISO_journal": "PLoS One",
"authors": [
"Kusama K",
"Bai R",
"Nakamura K",
"Okada S",
"Yasuda J",
"Imakawa K."
],
"DOI_URL": null
},
"PUB00102720": {
"PMID": 30098229,
"ISBN": null,
"volume": "12",
"issue": "10",
"year": 2018,
"title": "Identification of novel GLI1 target genes and regulatory circuits in human cancer cells.",
"URL": null,
"raw_pages": "1718-1734",
"medline_journal": "Mol Oncol",
"ISO_journal": "Mol Oncol",
"authors": [
"Diao Y",
"Rahman MF",
"Vyatkin Y",
"Azatyan A",
"St Laurent G",
"Kapranov P",
"Zaphiropoulos PG."
],
"DOI_URL": null
},
"PUB00102721": {
"PMID": 30918291,
"ISBN": null,
"volume": "9",
"issue": "1",
"year": 2019,
"title": "FOXS1 is regulated by GLI1 and miR-125a-5p and promotes cell proliferation and EMT in gastric cancer.",
"URL": null,
"raw_pages": "5281",
"medline_journal": "Sci Rep",
"ISO_journal": "Sci Rep",
"authors": [
"Wang S",
"Ran L",
"Zhang W",
"Leng X",
"Wang K",
"Liu G",
"Song J",
"Wang Y",
"Zhang X",
"Wang Y",
"Zhang L",
"Ma Y",
"Liu K",
"Li H",
"Zhang W",
"Qin G",
"Song F."
],
"DOI_URL": null
},
"PUB00102722": {
"PMID": 30500980,
"ISBN": null,
"volume": "120",
"issue": "3",
"year": 2019,
"title": "Overexpression of FOXS1 in gastric cancer cell lines inhibits proliferation, metastasis, and epithelial-mesenchymal transition of tumor through downregulating wnt/β-catenin pathway.",
"URL": null,
"raw_pages": "2897-2907",
"medline_journal": "J Cell Biochem",
"ISO_journal": "J Cell Biochem",
"authors": [
"Lu Q",
"Ma X",
"Li Y",
"Song W",
"Zhang L",
"Shu Y",
"Wan B."
],
"DOI_URL": null
},
"PUB00102723": {
"PMID": 17309606,
"ISBN": null,
"volume": "75",
"issue": "5",
"year": 2007,
"title": "Emergence of the sensory nervous system as defined by Foxs1 expression.",
"URL": null,
"raw_pages": "404-17",
"medline_journal": "Differentiation",
"ISO_journal": "Differentiation",
"authors": [
"Montelius A",
"Marmigere F",
"Baudet C",
"Aquino JB",
"Enerback S",
"Ernfors P."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036388",
"name": "Winged helix-like DNA-binding domain superfamily",
"type": "homologous_superfamily"
},
{
"accession": "IPR036390",
"name": "Winged helix DNA-binding domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 395,
"pathways": 0,
"proteins": 395,
"proteomes": 356,
"sets": 0,
"structural_models": {
"alphafold": 368,
"bfvd": 0
},
"structures": 0,
"taxa": 1113
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
