HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept
{
"metadata": {
"accession": "IPR047354",
"entry_id": null,
"type": "repeat",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd20116": "three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2)"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR047354",
"name": "Scm-like with four MBT domains protein 2, third MBT repeat",
"type": "Repeat",
"children": []
},
"name": {
"name": "Scm-like with four MBT domains protein 2, third MBT repeat",
"short": "MBT_SFMBT2_rpt3"
},
"description": [
{
"text": "<p>This entry represents the third MBT repeat of SFMBT2, which does not contain a semi-aromatic cage and may not bind methylated lysine residues.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>Scm-like with four MBT domains protein 2 (SFMBT2) is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development [[cite:PUB00102693], [cite:PUB00102695]]. It also negatively regulates cell migration and invasion in prostate cancer cells [[cite:PUB00102691], [cite:PUB00102692]]. SFMBT2 has been identified as a novel regulator of SOX9 expression in human chondrocytes, in which decreased levels of SFMBT2 contribute to the catabolic phenotype of chondrocytes. SFMBT2 is negatively regulated in osteoarthritis cartilage [[cite:PUB00102696], [cite:PUB00102694]].</p>\n\n<p>SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognises methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00102691": {
"PMID": 23385818,
"ISBN": null,
"volume": "38",
"issue": "1",
"year": 2013,
"title": "Regulation of DU145 prostate cancer cell growth by Scm-like with four mbt domains 2.",
"URL": null,
"raw_pages": "105-12",
"medline_journal": "J Biosci",
"ISO_journal": "J Biosci",
"authors": [
"Lee K",
"Na W",
"Maeng JH",
"Wu H",
"Ju BG."
],
"DOI_URL": null
},
"PUB00102692": {
"PMID": 27340776,
"ISBN": null,
"volume": "7",
"issue": "30",
"year": 2016,
"title": "SFMBT2 (Scm-like with four mbt domains 2) negatively regulates cell migration and invasion in prostate cancer cells.",
"URL": null,
"raw_pages": "48250-48264",
"medline_journal": "Oncotarget",
"ISO_journal": "Oncotarget",
"authors": [
"Gwak J",
"Shin JY",
"Lee K",
"Hong SK",
"Oh S",
"Goh SH",
"Kim WS",
"Ju BG."
],
"DOI_URL": null
},
"PUB00102693": {
"PMID": 24154523,
"ISBN": null,
"volume": "140",
"issue": "22",
"year": 2013,
"title": "The imprinted polycomb group gene Sfmbt2 is required for trophoblast maintenance and placenta development.",
"URL": null,
"raw_pages": "4480-9",
"medline_journal": "Development",
"ISO_journal": "Development",
"authors": [
"Miri K",
"Latham K",
"Panning B",
"Zhong Z",
"Andersen A",
"Varmuza S."
],
"DOI_URL": null
},
"PUB00102694": {
"PMID": 30133133,
"ISBN": null,
"volume": "22",
"issue": "11",
"year": 2018,
"title": "Down-regulated in OA cartilage, SFMBT2 contributes to NF-κB-mediated ECM degradation.",
"URL": null,
"raw_pages": "5753-5758",
"medline_journal": "J Cell Mol Med",
"ISO_journal": "J Cell Mol Med",
"authors": [
"Hussain S",
"Sun M",
"Min Z",
"Guo Y",
"Xu J",
"Mushtaq N",
"Heng L",
"Huang H",
"Zhao Y",
"Yuan Y",
"Hussain N",
"Zhang F",
"Han Y",
"Xu P",
"Sun J",
"Lu S."
],
"DOI_URL": null
},
"PUB00102695": {
"PMID": 18024232,
"ISBN": null,
"volume": "8",
"issue": "2",
"year": 2008,
"title": "The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues.",
"URL": null,
"raw_pages": "107-16",
"medline_journal": "Gene Expr Patterns",
"ISO_journal": "Gene Expr Patterns",
"authors": [
"Kuzmin A",
"Han Z",
"Golding MC",
"Mann MR",
"Latham KE",
"Varmuza S."
],
"DOI_URL": null
},
"PUB00102696": {
"PMID": 30272322,
"ISBN": null,
"volume": "42",
"issue": "6",
"year": 2018,
"title": "SFMBT2 positively regulates SOX9 and chondrocyte proliferation.",
"URL": null,
"raw_pages": "3503-3512",
"medline_journal": "Int J Mol Med",
"ISO_journal": "Int J Mol Med",
"authors": [
"Hussain S",
"Sun M",
"Guo Y",
"Mushtaq N",
"Zhao Y",
"Yuan Y",
"Hussain N",
"Osoro E",
"Suleiman A",
"Sadiq M",
"Zhang F",
"Han Y",
"Sun J",
"Lu S."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 644,
"pathways": 0,
"proteins": 644,
"proteomes": 478,
"sets": 0,
"structural_models": {
"alphafold": 582,
"bfvd": 0
},
"structures": 0,
"taxa": 1459
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
