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{
"metadata": {
"accession": "IPR047190",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd12600": "RNA recognition motif 2 (RRM2) found in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR000504",
"name": "RNA recognition motif domain",
"type": "Domain",
"children": [
{
"accession": "IPR003954",
"name": "RNA recognition motif domain, eukaryotic-type",
"type": "Domain",
"children": [
{
"accession": "IPR034653",
"name": "SPF45, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034827",
"name": "TIA-1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034830",
"name": "TIA-1, RNA recognition motif 2",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR007846",
"name": "RNA-recognition motif (RRM) Nup35-type domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR014886",
"name": "La protein, xRRM domain",
"type": "Domain",
"children": [
{
"accession": "IPR034910",
"name": "LARP7, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR045537",
"name": "La-related protein 7 homolog, xRRM domain",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR015047",
"name": "Synaptojanin-1/2, RNA recognition motif",
"type": "Domain",
"children": [
{
"accession": "IPR034971",
"name": "Synaptojanin-1, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034973",
"name": "Synaptojanin-2, RNA recognition motif",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR021790",
"name": "PTBP1-like, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR031766",
"name": "Occluded RNA-recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR033096",
"name": "Zinc finger protein 638, RNA recognition motif 1/2",
"type": "Domain",
"children": []
},
{
"accession": "IPR033107",
"name": "Eukaryotic translation initiation factor 4B, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR033110",
"name": "ROD1, RNA recognition motif 4",
"type": "Domain",
"children": []
},
{
"accession": "IPR033744",
"name": "RBM8, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034123",
"name": "RBM6, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034125",
"name": "RBM6, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034126",
"name": "RNA-binding protein Musashi homologue, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034131",
"name": "DAZ-associated protein 1, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034134",
"name": "DAZ-associated protein 1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034138",
"name": "Nucleolar protein 8, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034140",
"name": "Ecto-NOX disulfide-thiol exchanger, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034143",
"name": "snRNP70, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034146",
"name": "snRNP35, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034147",
"name": "RBM40, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034148",
"name": "NCBP2, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034150",
"name": "SF3B6, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034152",
"name": "SLIRP, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034156",
"name": "HRP1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034158",
"name": "SF3B4, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034159",
"name": "SF3B4, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034166",
"name": "Npl3, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034167",
"name": "Nab3, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034168",
"name": "Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034172",
"name": "SHARP, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034173",
"name": "SHARP, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034174",
"name": "SHARP, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034175",
"name": "SHARP, RNA recognition motif 4",
"type": "Domain",
"children": []
},
{
"accession": "IPR034177",
"name": "PPARGC1B, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034181",
"name": "Pre-mRNA-splicing factor Cwc2, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034186",
"name": "Pin4-like, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034189",
"name": "MARF1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034191",
"name": "MARF1, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034192",
"name": "SREK1, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034195",
"name": "Mrn1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034196",
"name": "CELF1/2, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034198",
"name": "CELF1/2, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034199",
"name": "CELF1/2, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034200",
"name": "RDM1, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034201",
"name": "RNPS1, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034203",
"name": "RBM45, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034206",
"name": "RBM45, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034207",
"name": "RBM45, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034208",
"name": "RBM45, RNA recognition motif 4",
"type": "Domain",
"children": []
},
{
"accession": "IPR034209",
"name": "PUF60, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034211",
"name": "PUF60, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034212",
"name": "PUF60, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034215",
"name": "RBM42, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034217",
"name": "SART3, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034218",
"name": "SART3, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034219",
"name": "ZCRB1, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034221",
"name": "RBM34, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034225",
"name": "Nop13/Rnp24, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034226",
"name": "Nop13/Rnp24, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034228",
"name": "Nop6, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034229",
"name": "eIF4H, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034230",
"name": "Nucleolin, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034233",
"name": "Nucleolin, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034234",
"name": "Nucleolin, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034235",
"name": "Nucleolin, RNA recognition motif 4",
"type": "Domain",
"children": []
},
{
"accession": "IPR034237",
"name": "FOX1, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034240",
"name": "eIF3G, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034244",
"name": "Rrt5, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034247",
"name": "Rrt5, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034254",
"name": "DNAJC17, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034256",
"name": "ALKBH8, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034257",
"name": "Acinus, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034261",
"name": "CNOT4, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034262",
"name": "TRMT2A, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034264",
"name": "RBM48, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034265",
"name": "MCM3AP, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034268",
"name": "RBM25, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034278",
"name": "RBM3/CIRBP, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034326",
"name": "ROD1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034349",
"name": "NUCL, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034350",
"name": "NUCL, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034351",
"name": "Nrp1, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034352",
"name": "Rim4/Msa1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034353",
"name": "ABT1/ESF2, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034356",
"name": "Slt11, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034357",
"name": "Yra1/Mlo3, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034358",
"name": "Vip1, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034359",
"name": "MTHFSD, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034360",
"name": "Vip1-like, RNA recognition motif, plant",
"type": "Domain",
"children": []
},
{
"accession": "IPR034361",
"name": "PHIP1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034362",
"name": "PHIP1, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034363",
"name": "eIF3B, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034364",
"name": "PABP, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034365",
"name": "AtC3H46-like, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034366",
"name": "Protein xmas, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034369",
"name": "SCAF4, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034370",
"name": "SCAF8, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034371",
"name": "UHMK1, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034374",
"name": "G3BP1, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034376",
"name": "G3BP2, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034388",
"name": "Star-PAP, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034396",
"name": "Yra2, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034397",
"name": "Prp24, RNA recognition motif1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034398",
"name": "Prp24, RNA recognition motif2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034403",
"name": "Srp1, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034404",
"name": "MSSP-1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034406",
"name": "RBMS3, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034407",
"name": "U1 small nuclear ribonucleoprotein A, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034409",
"name": "U1 small nuclear ribonucleoprotein A, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034411",
"name": "Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034414",
"name": "Dead end protein 1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034417",
"name": "Probable RNA-binding protein 19, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034418",
"name": "Probable RNA-binding protein 19, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034419",
"name": "Probable RNA-binding protein 19, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034420",
"name": "Probable RNA-binding protein 19, RNA recognition motif 4",
"type": "Domain",
"children": []
},
{
"accession": "IPR034421",
"name": "Probable RNA-binding protein 19, RNA recognition motif 6",
"type": "Domain",
"children": []
},
{
"accession": "IPR034423",
"name": "Probable RNA-binding protein 19, RNA recognition motif 5",
"type": "Domain",
"children": []
},
{
"accession": "IPR034424",
"name": "GRSF-1, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034425",
"name": "GRSF-1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034426",
"name": "GRSF-1, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034427",
"name": "ESRP1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034434",
"name": "Probable RNA-binding protein 46, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034435",
"name": "Probable RNA-binding protein 46, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034440",
"name": "RNA-binding protein 47, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034445",
"name": "RNA-binding protein 47, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034447",
"name": "Serine/arginine-rich splicing factor 11, RRM",
"type": "Domain",
"children": []
},
{
"accession": "IPR034451",
"name": "RNA-binding protein 27, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034453",
"name": "MEI2-like, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034467",
"name": "Set1A, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034468",
"name": "Set1B, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034469",
"name": "Ribosome biogenesis protein 15, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034470",
"name": "RBM15, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034472",
"name": "RBM15, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034473",
"name": "RBM15, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034475",
"name": "RBM15B, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034482",
"name": "Mrd1, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034486",
"name": "hnRNP A2/B1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034492",
"name": "TIAR, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034494",
"name": "TIAR, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034496",
"name": "TIAR, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034500",
"name": "RBM7, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034501",
"name": "RBM11, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034502",
"name": "Raly, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034503",
"name": "SRSF9, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034506",
"name": "RBM14, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034507",
"name": "RBM14, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034510",
"name": "SECp43, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034511",
"name": "SRSF6, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034516",
"name": "hnRNP A1/3, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034520",
"name": "SRSF1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034522",
"name": "PSP1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034523",
"name": "PSP1, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034525",
"name": "PSF, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034535",
"name": "RBM15B, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034536",
"name": "RBM15B, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034538",
"name": "ACF, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034540",
"name": "Prp24, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034544",
"name": "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034548",
"name": "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034552",
"name": "p54nrb, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034558",
"name": "p54nrb, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034562",
"name": "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034564",
"name": "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034588",
"name": "RBM12B, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034591",
"name": "RBM12, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034594",
"name": "RBM12, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034630",
"name": "MEF-2, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034631",
"name": "MEF-2, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034633",
"name": "Ribonucleoprotein PTB-binding 1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034635",
"name": "Ribonucleoprotein PTB-binding 1, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034636",
"name": "Ribonucleoprotein PTB-binding 2, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034637",
"name": "Negative elongation factor E, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034648",
"name": "CELF-3/4/5/6, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034651",
"name": "SRSF7, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034769",
"name": "Cleavage and polyadenylation specificity factor subunit 6, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034773",
"name": "CPSF7, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034775",
"name": "Protein elav, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034777",
"name": "Nop12, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034781",
"name": "Scaffold attachment factor B1/2, RNA binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034784",
"name": "PDIP3, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034787",
"name": "RBPMS2, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034788",
"name": "Protein couch potato, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034790",
"name": "RBM20, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034792",
"name": "PTBPH1/PTBPH2, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034793",
"name": "PTBPH1/PTBPH2, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034794",
"name": "PTBPH1/PTBPH2, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034795",
"name": "PTBPH3, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034796",
"name": "PTBPH3, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034797",
"name": "PTBPH3, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034799",
"name": "PTBP2, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034800",
"name": "PTBP2, RNA recognition motif 4",
"type": "Domain",
"children": []
},
{
"accession": "IPR034801",
"name": "hnRNP A0, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034805",
"name": "Nop4, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034806",
"name": "Nop4, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034808",
"name": "Nop4, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034809",
"name": "Nop4, RNA recognition motif 4",
"type": "Domain",
"children": []
},
{
"accession": "IPR034816",
"name": "hnRNP-L, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034823",
"name": "CID8-like protein, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034825",
"name": "CID8-like protein, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034833",
"name": "PGC-1alpha, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034834",
"name": "PGC-1-related coactivator, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034837",
"name": "IGF2BP1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034842",
"name": "IGF2BP1, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034843",
"name": "IGF2BP2, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034845",
"name": "hnRNP A1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034846",
"name": "hnRNPAB, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034847",
"name": "hnRNP DL, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034854",
"name": "RBM12, RNA recognition motif 5",
"type": "Domain",
"children": []
},
{
"accession": "IPR034855",
"name": "RBM12, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034856",
"name": "RBM12, RNA recognition motif 4",
"type": "Domain",
"children": []
},
{
"accession": "IPR034858",
"name": "RBM12B, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034859",
"name": "RBM26, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034862",
"name": "Fungal Mei2-like, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034863",
"name": "Fungal Mei2-like, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034869",
"name": "EWS, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034878",
"name": "Plant La-related protein, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034880",
"name": "La-related protein 6, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034887",
"name": "LARP7, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034890",
"name": "Rrp7A, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034894",
"name": "Nrd1/Seb1, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034897",
"name": "RBM4, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034898",
"name": "RBM4, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034914",
"name": "HuB, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034915",
"name": "HuC, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034918",
"name": "HuD, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034927",
"name": "TNRC6C, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034928",
"name": "Matrin-3, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034930",
"name": "Matrin-3, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034969",
"name": "hnRNPH3, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034970",
"name": "hnRNPH3, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034977",
"name": "CPEB-1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034980",
"name": "RNA-binding protein fusilli, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034983",
"name": "hnRPLL, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034985",
"name": "hnRPLL, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034986",
"name": "hnRPLL, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034988",
"name": "DAZ/BOULE, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR034990",
"name": "hnRNPM, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR034991",
"name": "RNA-binding protein 5, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034992",
"name": "RNA-binding protein 10, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034993",
"name": "RNA-binding protein 5, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034995",
"name": "SRSF9, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034996",
"name": "HuR, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR034999",
"name": "HuB, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035000",
"name": "PTBP1, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035001",
"name": "PTBP1, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035002",
"name": "PTBP2, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035005",
"name": "hnRNP-L, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035008",
"name": "hnRNP-L, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035009",
"name": "SR140, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR037551",
"name": "DAZ, RNA recognition motif, vertebrates",
"type": "Domain",
"children": []
},
{
"accession": "IPR039157",
"name": "RNA-binding protein 18, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR045305",
"name": "PABP, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR045844",
"name": "Ist3-like, RNA recognition motif",
"type": "Domain",
"children": []
},
{
"accession": "IPR047044",
"name": "RNA-binding protein 47, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR047188",
"name": "RNA-binding protein 12B, RNA recognition motif 4",
"type": "Domain",
"children": []
},
{
"accession": "IPR047189",
"name": "Nop12, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR047190",
"name": "Serine/arginine-rich splicing factor 4/6, RNA recognition motif 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR047193",
"name": "FCA, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR047837",
"name": "Probable RNA-binding protein 46, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR047942",
"name": "Ribonucleoprotein PTB-binding 2, RNA recognition motif 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR047943",
"name": "Ribonucleoprotein PTB-binding 2, RNA recognition motif 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR048289",
"name": "NsCP33-like, RNA recognition motif 2",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "Serine/arginine-rich splicing factor 4/6, RNA recognition motif 2",
"short": "RRM2_SRSF4/6"
},
"description": [
{
"text": "<p>This is the RNA recognition motif 2 (RRM2) in serine/arginine (SR) proteins serine/arginine-rich splicing factor 4 (SRSF4 or SRp75 or SFRS4), 6 (SRSF6, also known as pre-mRNA-splicing factor SRP55) and related proteins. SRSF4 plays an important role in both constitutive and alternative, splicing of many pre-mRNAs [[cite:PUB00085623], [cite:PUB00085624]]. It can shuttle between the nucleus and cytoplasm. Members in this family contain two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), followed by a C-terminal RS domains rich in serine-arginine dipeptides [[cite:PUB00085625]]. SRSF6 plays a role in constitutive splicing and modulates the selection of alternative splice sites. It plays a role in the alternative splicing of MAPT/Tau exon 10 [[cite:PUB00070423], [cite:PUB00158838]]. It binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. SRSF6 plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing [[cite:PUB00070420]].</p>",
"llm": false,
"checked": false,
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}
],
"wikipedia": null,
"literature": {
"PUB00085625": {
"PMID": 8321209,
"ISBN": null,
"volume": "13",
"issue": "7",
"year": 1993,
"title": "Human SR proteins and isolation of a cDNA encoding SRp75.",
"URL": null,
"raw_pages": "4023-8",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Zahler AM",
"Neugebauer KM",
"Stolk JA",
"Roth MB."
],
"DOI_URL": "https://doi.org/10.1128/MCB.13.7.4023"
},
"PUB00085623": {
"PMID": 21723381,
"ISBN": null,
"volume": "485",
"issue": "2",
"year": 2011,
"title": "An SRp75/hnRNPG complex interacting with hnRNPE2 regulates the 5' splice site of tau exon 10, whose misregulation causes frontotemporal dementia.",
"URL": null,
"raw_pages": "130-8",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Wang Y",
"Wang J",
"Gao L",
"Stamm S",
"Andreadis A."
],
"DOI_URL": "https://doi.org/10.1016/j.gene.2011.06.020"
},
"PUB00085624": {
"PMID": 20639886,
"ISBN": null,
"volume": "17",
"issue": "8",
"year": 2010,
"title": "Global analysis reveals SRp20- and SRp75-specific mRNPs in cycling and neural cells.",
"URL": null,
"raw_pages": "962-70",
"medline_journal": "Nat Struct Mol Biol",
"ISO_journal": "Nat. Struct. Mol. Biol.",
"authors": [
"Anko ML",
"Morales L",
"Henry I",
"Beyer A",
"Neugebauer KM."
],
"DOI_URL": "https://doi.org/10.1038/nsmb.1862"
},
"PUB00158838": {
"PMID": 15009664,
"ISBN": null,
"volume": "88",
"issue": "5",
"year": 2004,
"title": "Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.",
"URL": null,
"raw_pages": "1078-90",
"medline_journal": "J Neurochem",
"ISO_journal": "J Neurochem",
"authors": [
"Wang J",
"Gao QS",
"Wang Y",
"Lafyatis R",
"Stamm S",
"Andreadis A."
],
"DOI_URL": "https://doi.org/10.1046/j.1471-4159.2003.02232.x"
},
"PUB00070420": {
"PMID": 24440982,
"ISBN": null,
"volume": "21",
"issue": "2",
"year": 2014,
"title": "Splicing factor SRSF6 promotes hyperplasia of sensitized skin.",
"URL": null,
"raw_pages": "189-97",
"medline_journal": "Nat Struct Mol Biol",
"ISO_journal": "Nat. Struct. Mol. Biol.",
"authors": [
"Jensen MA",
"Wilkinson JE",
"Krainer AR."
],
"DOI_URL": "http://dx.doi.org/10.1038/nsmb.2756"
},
"PUB00070423": {
"PMID": 22767602,
"ISBN": null,
"volume": "287",
"issue": "36",
"year": 2012,
"title": "Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion.",
"URL": null,
"raw_pages": "30497-506",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Yin X",
"Jin N",
"Gu J",
"Shi J",
"Zhou J",
"Gong CX",
"Iqbal K",
"Grundke-Iqbal I",
"Liu F."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M112.355412"
}
},
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{
"accession": "IPR012677",
"name": "Nucleotide-binding alpha-beta plait domain superfamily",
"type": "homologous_superfamily"
},
{
"accession": "IPR035979",
"name": "RNA-binding domain superfamily",
"type": "homologous_superfamily"
}
],
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"taxa": 3354
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}
