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{
    "metadata": {
        "accession": "IPR047046",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR42692": "NUCLEOTIDE PYROPHOSPHOHYDROLASE"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR047046",
            "name": "NTP pyrophosphohydrolase MazG-related, YpjD/YvdC",
            "type": "Family",
            "children": [
                {
                    "accession": "IPR011411",
                    "name": "NTP pyrophosphohydrolase MazG-related, YvdC",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR012359",
                    "name": "NTP pyrophosphohydrolase MazG-related, YpjD",
                    "type": "Family",
                    "children": []
                }
            ]
        },
        "name": {
            "name": "NTP pyrophosphohydrolase MazG-related, YpjD/YvdC",
            "short": "YpjD/YvdC"
        },
        "description": [
            {
                "text": "<p>This family represents a group of distantly related to MazG-type NTP pyrophosphohydrolase (NTP-PPase) which contain the conserved residues of the MazG domain (at least three of the Glu residues, Asp, Lys and Arg), including those shown to be functionally important [[cite:PUB00013554]]. This entry includes the putative pyrophosphatases YpjD and YvdC from Bacillus subtilis. Although its biological role has not been described in detail, YpjD shows significant sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, BsYpjD contains a single MazG-like domain [[cite:PUB00079704]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00013554": {
                "PMID": 12657645,
                "ISBN": null,
                "volume": "278",
                "issue": "24",
                "year": 2003,
                "title": "Thermotoga maritima MazG protein has both nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase activities.",
                "URL": null,
                "raw_pages": "21408-14",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J. Biol. Chem.",
                "authors": [
                    "Zhang J",
                    "Zhang Y",
                    "Inouye M."
                ],
                "DOI_URL": "http://dx.doi.org/10.1074/jbc.M213294200"
            },
            "PUB00079704": {
                "PMID": 15740738,
                "ISBN": null,
                "volume": "347",
                "issue": "2",
                "year": 2005,
                "title": "Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential \"house-cleaning\" functions.",
                "URL": null,
                "raw_pages": "243-55",
                "medline_journal": "J Mol Biol",
                "ISO_journal": "J. Mol. Biol.",
                "authors": [
                    "Moroz OV",
                    "Murzin AG",
                    "Makarova KS",
                    "Koonin EV",
                    "Wilson KS",
                    "Galperin MY."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/j.jmb.2005.01.030"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 5701,
            "pathways": 0,
            "proteins": 5701,
            "proteomes": 3887,
            "sets": 0,
            "structural_models": {
                "alphafold": 4264,
                "bfvd": 0
            },
            "structures": 2,
            "taxa": 6073
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}