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{
    "metadata": {
        "accession": "IPR046389",
        "entry_id": null,
        "type": "family",
        "go_terms": [
            {
                "identifier": "GO:0030337",
                "name": "DNA polymerase processivity factor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "hamap": {
                "MF_04161": "Sliding clamp"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR046389",
            "name": "Sliding clamp",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Sliding clamp",
            "short": "Sliding_clamp_T4"
        },
        "description": [
            {
                "text": "<p>This family includes sliding clamp protein from Bacteriophage T4 (also known as gp45), which encircles the genomic DNA and links the DNA polymerase to the template to control the processivity of DNA synthesis. It is responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication [[cite:PUB00100546]]. The interaction with the sliding-clamp-loader opens the sliding clamp so that it can be loaded around the DNA template [[cite:PUB00065743]]. During transcription, encircles the DNA and tethers host RNA polymerase (RNAP) to it [[cite:PUB00100539]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00065743": {
                "PMID": 22194570,
                "ISBN": null,
                "volume": "334",
                "issue": "6063",
                "year": 2011,
                "title": "How a DNA polymerase clamp loader opens a sliding clamp.",
                "URL": null,
                "raw_pages": "1675-80",
                "medline_journal": "Science",
                "ISO_journal": "Science",
                "authors": [
                    "Kelch BA",
                    "Makino DL",
                    "O'Donnell M",
                    "Kuriyan J."
                ],
                "DOI_URL": "http://dx.doi.org/10.1126/science.1211884"
            },
            "PUB00100539": {
                "PMID": 33602900,
                "ISBN": null,
                "volume": "12",
                "issue": "1",
                "year": 2021,
                "title": "Transcription activation by a sliding clamp.",
                "URL": null,
                "raw_pages": "1131",
                "medline_journal": "Nat Commun",
                "ISO_journal": "Nat Commun",
                "authors": [
                    "Shi J",
                    "Wen A",
                    "Jin S",
                    "Gao B",
                    "Huang Y",
                    "Feng Y."
                ],
                "DOI_URL": null
            },
            "PUB00100546": {
                "PMID": 10535942,
                "ISBN": null,
                "volume": "96",
                "issue": "22",
                "year": 1999,
                "title": "Opening of a monomer-monomer interface of the trimeric bacteriophage T4-coded GP45 sliding clamp is required for clamp loading onto DNA.",
                "URL": null,
                "raw_pages": "12448-53",
                "medline_journal": "Proc Natl Acad Sci U S A",
                "ISO_journal": "Proc Natl Acad Sci U S A",
                "authors": [
                    "Latham GJ",
                    "Dong F",
                    "Pietroni P",
                    "Dozono JM",
                    "Bacheller DJ",
                    "von Hippel PH."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 569,
            "pathways": 0,
            "proteins": 569,
            "proteomes": 342,
            "sets": 0,
            "structural_models": {
                "alphafold": 23,
                "bfvd": 4
            },
            "structures": 12,
            "taxa": 1029
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}