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{
"metadata": {
"accession": "IPR045152",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0031087",
"name": "deadenylation-independent decapping of nuclear-transcribed mRNA",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"panther": {
"PTHR15598": "ENHANCER OF MRNA-DECAPPING PROTEIN 4"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR045152",
"name": "Enhancer of mRNA-decapping protein 4-like",
"type": "Family",
"children": []
},
"name": {
"name": "Enhancer of mRNA-decapping protein 4-like",
"short": "EDC4-like"
},
"description": [
{
"text": "<p>Ge-1, also known as EDC4 (enhancer of mRNA-decapping protein 4), is a regulator of mRNA decapping to function in the mRNA P-bodies within the cytoplasm. It has been shown to interact with mTORC1 [[cite:PUB00098143]], coenzyme A synthase [[cite:PUB00098142]] and MARF1 [[cite:PUB00098144]]. It is also involved in the regulation of immune system [[cite:PUB00098145]].</p>\n\n<p>This entry also includes EDC4 homologues from fungi and plants [[cite:PUB00098147]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00098142": {
"PMID": 22982864,
"ISBN": null,
"volume": "586",
"issue": "20",
"year": 2012,
"title": "EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase.",
"URL": null,
"raw_pages": "3590-5",
"medline_journal": "FEBS Lett",
"ISO_journal": "FEBS Lett",
"authors": [
"Gudkova D",
"Panasyuk G",
"Nemazanyy I",
"Zhyvoloup A",
"Monteil P",
"Filonenko V",
"Gout I."
],
"DOI_URL": null
},
"PUB00098144": {
"PMID": 32510323,
"ISBN": null,
"volume": "9",
"issue": null,
"year": 2020,
"title": "A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay.",
"URL": null,
"raw_pages": null,
"medline_journal": "Elife",
"ISO_journal": "Elife",
"authors": [
"Brothers WR",
"Hebert S",
"Kleinman CL",
"Fabian MR."
],
"DOI_URL": null
},
"PUB00098143": {
"PMID": 25514416,
"ISBN": null,
"volume": "15",
"issue": "12",
"year": 2014,
"title": "Crosstalk between Edc4 and mammalian target of rapamycin complex 1 (mTORC1) signaling in mRNA decapping.",
"URL": null,
"raw_pages": "23179-95",
"medline_journal": "Int J Mol Sci",
"ISO_journal": "Int J Mol Sci",
"authors": [
"Rahman H",
"Qasim M",
"Oellerich M",
"Asif AR."
],
"DOI_URL": null
},
"PUB00098145": {
"PMID": 25970328,
"ISBN": null,
"volume": "10",
"issue": "5",
"year": 2015,
"title": "The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6.",
"URL": null,
"raw_pages": "e0123223",
"medline_journal": "PLoS One",
"ISO_journal": "PLoS One",
"authors": [
"Seto E",
"Yoshida-Sugitani R",
"Kobayashi T",
"Toyama-Sorimachi N."
],
"DOI_URL": null
},
"PUB00098147": {
"PMID": 17513503,
"ISBN": null,
"volume": "19",
"issue": "5",
"year": 2007,
"title": "Components of the Arabidopsis mRNA decapping complex are required for early seedling development.",
"URL": null,
"raw_pages": "1549-64",
"medline_journal": "Plant Cell",
"ISO_journal": "Plant Cell",
"authors": [
"Goeres DC",
"Van Norman JM",
"Zhang W",
"Fauver NA",
"Spencer ML",
"Sieburth LE."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR044938",
"name": "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 6175,
"pathways": 5,
"proteins": 6175,
"proteomes": 2767,
"sets": 0,
"structural_models": {
"alphafold": 2207,
"bfvd": 0
},
"structures": 1,
"taxa": 8005
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "2vxg",
"name": "Crystal structure of the conserved C-terminal region of Ge-1"
}
}
}
